A Synthetic MUC1 Anticancer Vaccine Containing Mannose Ligands for Targeting Macrophages and Dendritic Cells

A MUC1 anticancer vaccine equipped with covalently linked divalent mannose ligands was found to improve the antigen uptake and presentation by targeting mannose‐receptor‐positive macrophages and dendritic cells. It induced much stronger specific IgG immune responses in mice than the non‐mannosylated...

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Veröffentlicht in:	ChemMedChem 2018-01, Vol.13 (1), p.25-29
Hauptverfasser:	Glaffig, Markus, Stergiou, Natascha, Hartmann, Sebastian, Schmitt, Edgar, Kunz, Horst
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antigen presentation antitumor vaccines Binding Breast cancer Cancer cancer immunotherapy CD4 antigen Dendritic cells Immune response Immunoglobulin G Ligands Lymphocytes Lymphocytes T macrophage activation Macrophages Mannose mannose receptors MUC1 glycopeptide Organs Tumor cells Vaccines Valency
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