Impaired Bcl3 Up-regulation Leads to Enhanced Lipopolysaccharide-induced Interleukin (IL)-23P19 Gene Expression in IL-10 super(-/-) Mice

Genetic and biochemical analyses show that IL-23p19 plays a central role in mediating bacteria-induced colitis in interleukin-10-deficient (IL-10 super(-/-)) mice. The molecular mechanisms responsible for the dysregulated innate host response leading to enhanced IL-23 gene expression in IL-10 super(...

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Veröffentlicht in:	The Journal of biological chemistry 2008-05, Vol.283 (21), p.14182-14189
Hauptverfasser:	Muehlbauer, Marcus, Chilton, Paula M, Mitchell, Thomas C, Jobin, Christian
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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