The effect of oxidative stress on the mutation rate of Mycobacterium tuberculosis with impaired catalase/peroxidase function

Objectives To determine the effect of oxidative stress on isoniazid-resistant Mycobacterium tuberculosis deficient in catalase/peroxidase activity to varying degrees through mutation in katG. Methods The mutation rate was determined for a set of isogenic strains with different katG alleles giving di...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2008-10, Vol.62 (4), p.709-712
Hauptverfasser:	O'Sullivan, D. M., McHugh, T. D., Gillespie, S. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteria Bacterial diseases Bacterial Proteins - genetics Biological and medical sciences Catalase - genetics DNA Mutational Analysis DNA, Bacterial - chemistry DNA, Bacterial - genetics DNA-Directed RNA Polymerases - genetics Drug Resistance, Bacterial Genotype Human bacterial diseases Hydrogen Peroxide - pharmacology Infectious diseases isoniazid M. tuberculosis Medical sciences Microbiology Mutation Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - enzymology Mycobacterium tuberculosis - genetics Oxidants - pharmacology Oxidation Oxidative Stress oxidative stress response Pharmacology. Drug treatments Rifampin - pharmacology Sequence Analysis, DNA Tuberculosis Tuberculosis and atypical mycobacterial infections
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