Phenotypic and Structural Analyses of Hepatitis C Virus NS3 Protease Arg super(155) Variants: Sensitivity To Telaprevir (VX-950) And Interferon alpha

Telaprevir (VX-950) is a highly selective, potent inhibitor of the hepatitis C virus (HCV) NS3.4A serine protease. It has demonstrated strong antiviral activity in patients chronically infected with genotype 1 HCV when dosed alone or in combination with peginterferon alfa-2a. Substitutions of Arg su...

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Veröffentlicht in:	The Journal of biological chemistry 2007-08, Vol.282 (31), p.22619-22628
Hauptverfasser:	Zhou, Yi, Mueh, Ute, Hanzelka, Brian L, Bartels, Doug J, Wei, Yunyi, Rao, BGovinda, Brennan, Debra L, Tigges, Ann M, Swenson, Lora, Kwong, Ann D, Lin, Chao
Format:	Artikel
Sprache:	eng
Schlagworte:	Hepatitis C virus
Online-Zugang:	Volltext
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