Article: The Signal Transducer STAT5 Inhibits Plasmacytoid Dendritic Cell Development by Suppressing Transcription Factor IRF8

The development of distinct dendritic cell (DC) subsets is regulated by cytokines. The ligand for the FMS-like tyrosine kinase 3 receptor (Flt3L) is necessary for plasmacytoid DC (pDC) and conventional DC (cDC) maturation. The cytokine GM-CSF inhibits Flt3L-driven pDC production while promoting cDC...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2008-04, Vol.28 (4), p.509-520
Hauptverfasser:	Esashi, Eiji, Wang, Yui-Hsi, Perng, Olivia, Qin, Xiao-Feng, Liu, Yong-Jun, Watowich, Stephanie S
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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