Degadration of mismatch repair hMutSα heterodimer by the ubiquitin-proteasome pathway

Mismatch repair plays a critical role in genome stability. This process requires several proteins including hMSH2/hMSH6 (hMutSα) heterodimer involved in the first stage of the process, the mispair recognition. We previously reported that in U937 and HL-60 cell lines, hMSH2 and hMSH6 protein expressi...

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Veröffentlicht in:	FEBS letters 2004-03, Vol.562 (1-3), p.40-44
Hauptverfasser:	Hernandez-Pigeon, Hélène, Laurent, Guy, Humbert, Odile, Salles, Bernard, Lautier, Dominique
Format:	Artikel
Sprache:	eng
Schlagworte:	CHX, cycloheximide DCIC, dichloroisocoumarin MCA, 7-amino-4-methylcoumarin Mismatch repair MMR, mismatch repair MSH2 MSH6 MSI, microsatellite instability Proteasome Protein stability RRL, rabbit reticulocyte lysate TPCK, 1-chloro-3-tosylamido-4-phenyl-2-butanone Ub, ubiquitin Ubiquitination
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