Human Kruppel-like Factor 5 Is a Target of the E3 Ubiquitin Ligase WWP1 for Proteolysis in Epithelial Cells

The transcription factor KLF5 plays an important role in human carcinogenesis. In epithelial cells, the KLF5 protein is tightly regulated by the ubiquitin-proteasome pathway. To better understand the mechanisms for the regulation of KLF5 protein, we identified and characterized an E3 ubiquitin ligas...

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Veröffentlicht in:	The Journal of biological chemistry 2005-12, Vol.280 (50), p.41553-41561
Hauptverfasser:	Chen, Ceshi, Sun, Xiaodong, Guo, Peng, Dong, Xue-Yuan, Sethi, Pooja, Cheng, Xiaohong, Zhou, Jun, Ling, Junxiu, Simons, Jonathan W., Lingrel, Jerry B., Dong, Jin-Tang
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Blotting, Western Breast Neoplasms - metabolism Catalysis Cell Line, Tumor Cysteine - chemistry DNA - chemistry Epithelial Cells - metabolism Female Gene Expression Regulation Gene Expression Regulation, Neoplastic Glutathione Transferase - metabolism Humans Immunoprecipitation Kruppel-Like Transcription Factors - chemistry Kruppel-Like Transcription Factors - metabolism Luciferases - metabolism Male Microscopy, Confocal Microscopy, Fluorescence Neoplasms - metabolism Plasmids - metabolism Prostatic Neoplasms - metabolism Proteasome Endopeptidase Complex - metabolism Protein Binding Protein Biosynthesis Protein Structure, Tertiary Recombinant Fusion Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA - chemistry RNA, Small Interfering - metabolism Time Factors Transcriptional Activation Transfection Ubiquitin - chemistry Ubiquitin-Protein Ligases - chemistry Ubiquitin-Protein Ligases - metabolism
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