Histone deacetylase inhibitors improve learning consolidation in young and in KA-induced-neurodegeneration and SAMP-8-mutant mice

Histone deacetylases (HDAC) are enzymes that maintain chromatin in a condensate state, related with absence of transcription. We have studied the role of HDAC on learning and memory processes. Both eyeblink classical conditioning (EBCC) and object recognition memory (ORM) induced an increase in hist...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular and cellular neuroscience 2008-10, Vol.39 (2), p.193-201
Hauptverfasser:	Fontán-Lozano, Ángela, Romero-Granados, Rocío, Troncoso, Julieta, Múnera, Alejandro, Delgado-García, José María, Carrión, Ángel M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation - drug effects Aging Aging - genetics Analysis of Variance Animals Association Learning - drug effects Blinking - drug effects Conditioning, Classical - drug effects Consolidation Disease Models, Animal Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Gene expression Histone deacetylase Histone Deacetylase Inhibitors Histone H3 acetylation Histones - metabolism Hydroxamic Acids - pharmacology Hydroxamic Acids - therapeutic use Kainic Acid Learning Male Memory - drug effects Memory - physiology Mice Mice, Mutant Strains Neurodegenerative Diseases - chemically induced Neurodegenerative Diseases - drug therapy Neurodegenerative Diseases - physiopathology Pattern Recognition, Visual - drug effects SAMP-8 mice Sodium butyrate Time Factors Trichostatin A
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!