Experimental model to assess possible medicinal herb interaction with a radiobiocomplex: Qualitative and quantitative analysis of kidney, liver and duodenum isolated from treated rats
Ginkgo biloba extract (EGb) has been used as a medicinal herb. Several biological properties have been associated with this extract, especially, in the increase of the blood flow, in the action as platelet activating factor antagonism and in the prevention of the membrane against the damage caused b...
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| Veröffentlicht in: | Food and chemical toxicology 2007, Vol.45 (1), p.19-23 |
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| creator | Moreno, S.R.F. Carvalho, J.J. Nascimento, A.L. Pereira, M. Rocha, E.K. Olej, B. Caldas, L.Q.A. Bernardo-Filho, M. |
| description | Ginkgo biloba extract (EGb) has been used as a medicinal herb. Several biological properties have been associated with this extract, especially, in the increase of the blood flow, in the action as platelet activating factor antagonism and in the prevention of the membrane against the damage caused by free radicals. Radiobiocomplexes have been utilized in various nuclear medicine procedures helping in the diagnosis and/or treatment of human diseases. Many substances have been reported to affect the bioavailability of different radiobiocomplexes. The aim of this work was to evaluate the possible influence of an EGb on the bioavailability of the sodium pertechnetate (
99mTcO
4Na) and on the morphometry of some organs isolated from rats. These animals were treated with EGb and
99mTcO
4Na was injected. The animals were sacrificed, the organs isolated, counted in a well counter and the percentage of radioactivity per gram of each organ was calculated. The results showed that EGb decreased the uptake of the
99mTcO
4Na in the duodenum (
P
<
0.05). Moreover, morphometric analysis has revealed significant modifications (
P
<
0.05) on kidney, liver and duodenum due to the cited treatment. It is speculated that the substances present in the EGb could act directly or generate metabolites capable to promote changes in organs (kidney, liver and duodenum), however, only significant alteration in the uptake of the
99mTcO
4Na in the duodenum. |
| doi_str_mv | 10.1016/j.fct.2006.04.007 |
| format | Article |
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99mTcO
4Na) and on the morphometry of some organs isolated from rats. These animals were treated with EGb and
99mTcO
4Na was injected. The animals were sacrificed, the organs isolated, counted in a well counter and the percentage of radioactivity per gram of each organ was calculated. The results showed that EGb decreased the uptake of the
99mTcO
4Na in the duodenum (
P
<
0.05). Moreover, morphometric analysis has revealed significant modifications (
P
<
0.05) on kidney, liver and duodenum due to the cited treatment. It is speculated that the substances present in the EGb could act directly or generate metabolites capable to promote changes in organs (kidney, liver and duodenum), however, only significant alteration in the uptake of the
99mTcO
4Na in the duodenum.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/j.fct.2006.04.007</identifier><identifier>PMID: 17052830</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>animal models ; Animals ; antagonists ; antioxidant activity ; antioxidants ; bioactive properties ; Bioavailability ; Biological and medical sciences ; Biological Availability ; Drug Interactions ; Duodenum - drug effects ; Duodenum - metabolism ; Duodenum - pathology ; Female ; free radicals ; G. biloba extract ; General pharmacology ; Ginkgo biloba ; Ginkgo biloba - chemistry ; herbal medicines ; Kidney - drug effects ; Kidney - metabolism ; Kidney - pathology ; Kidney Glomerulus - drug effects ; Kidney Glomerulus - pathology ; Liver - drug effects ; Liver - metabolism ; Liver - pathology ; Medical sciences ; medicinal plants ; Models, Animal ; Morphometry ; nutrient availability ; nutrient-nutrient interactions ; nutritive value ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; plant extracts ; Plant Extracts - toxicity ; platelet-activating factor ; Radiobiocomplex ; Radiopharmaceuticals - pharmacokinetics ; Rats ; Rats, Wistar ; Sodium pertechnetate ; Sodium Pertechnetate Tc 99m - pharmacokinetics ; Tissue Distribution ; Toxicology</subject><ispartof>Food and chemical toxicology, 2007, Vol.45 (1), p.19-23</ispartof><rights>2006 Elsevier Ltd</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-60a417b803f0e3f3a6f3e51543109cfd0c28dfa2f0967200fddafe9f2741a8e23</citedby><cites>FETCH-LOGICAL-c436t-60a417b803f0e3f3a6f3e51543109cfd0c28dfa2f0967200fddafe9f2741a8e23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.fct.2006.04.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18445498$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17052830$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moreno, S.R.F.</creatorcontrib><creatorcontrib>Carvalho, J.J.</creatorcontrib><creatorcontrib>Nascimento, A.L.</creatorcontrib><creatorcontrib>Pereira, M.</creatorcontrib><creatorcontrib>Rocha, E.K.</creatorcontrib><creatorcontrib>Olej, B.</creatorcontrib><creatorcontrib>Caldas, L.Q.A.</creatorcontrib><creatorcontrib>Bernardo-Filho, M.</creatorcontrib><title>Experimental model to assess possible medicinal herb interaction with a radiobiocomplex: Qualitative and quantitative analysis of kidney, liver and duodenum isolated from treated rats</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>Ginkgo biloba extract (EGb) has been used as a medicinal herb. Several biological properties have been associated with this extract, especially, in the increase of the blood flow, in the action as platelet activating factor antagonism and in the prevention of the membrane against the damage caused by free radicals. Radiobiocomplexes have been utilized in various nuclear medicine procedures helping in the diagnosis and/or treatment of human diseases. Many substances have been reported to affect the bioavailability of different radiobiocomplexes. The aim of this work was to evaluate the possible influence of an EGb on the bioavailability of the sodium pertechnetate (
99mTcO
4Na) and on the morphometry of some organs isolated from rats. These animals were treated with EGb and
99mTcO
4Na was injected. The animals were sacrificed, the organs isolated, counted in a well counter and the percentage of radioactivity per gram of each organ was calculated. The results showed that EGb decreased the uptake of the
99mTcO
4Na in the duodenum (
P
<
0.05). Moreover, morphometric analysis has revealed significant modifications (
P
<
0.05) on kidney, liver and duodenum due to the cited treatment. It is speculated that the substances present in the EGb could act directly or generate metabolites capable to promote changes in organs (kidney, liver and duodenum), however, only significant alteration in the uptake of the
99mTcO
4Na in the duodenum.</description><subject>animal models</subject><subject>Animals</subject><subject>antagonists</subject><subject>antioxidant activity</subject><subject>antioxidants</subject><subject>bioactive properties</subject><subject>Bioavailability</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>Drug Interactions</subject><subject>Duodenum - drug effects</subject><subject>Duodenum - metabolism</subject><subject>Duodenum - pathology</subject><subject>Female</subject><subject>free radicals</subject><subject>G. biloba extract</subject><subject>General pharmacology</subject><subject>Ginkgo biloba</subject><subject>Ginkgo biloba - chemistry</subject><subject>herbal medicines</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Kidney - pathology</subject><subject>Kidney Glomerulus - drug effects</subject><subject>Kidney Glomerulus - pathology</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>Models, Animal</subject><subject>Morphometry</subject><subject>nutrient availability</subject><subject>nutrient-nutrient interactions</subject><subject>nutritive value</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>plant extracts</subject><subject>Plant Extracts - toxicity</subject><subject>platelet-activating factor</subject><subject>Radiobiocomplex</subject><subject>Radiopharmaceuticals - pharmacokinetics</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sodium pertechnetate</subject><subject>Sodium Pertechnetate Tc 99m - pharmacokinetics</subject><subject>Tissue Distribution</subject><subject>Toxicology</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctuEzEUhkcIRNPCA7ABb-iKBHvsuZUVqspFqoQQdG2dsY-pg8dObU9pnozXw00iZcfKsv2di_6vql4xumKUte_XK6Pyqqa0XVGxorR7Ui1Y3_Flyxv2tFrQuuuX7cCak-o0pTUtBOva59UJ62hT95wuqr9XDxuMdkKfwZEpaHQkBwIpYUpkE1Kyo0MyobbK-oLcYhyJ9RkjqGyDJ39sviVAImgbRhtUmDYOHy7I9xmczZDtPRLwmtzN4PPxAdw22USCIb-t9rh9R1z5iDtUz2UPP0_EpuAgoyYmhonkiLtLhJxeVM8MuIQvD-dZdfPp6ufll-X1t89fLz9eL5XgbV62FATrxp5yQ5EbDq3h2LBGcEYHZTRVda8N1IYObVeCNFqDwcHUnWDQY83PqvN9300MdzOmLCebFDoHHsOcJBs6OgjWFJDtQRVLaBGN3JRYIW4lo_LRllzLYks-2pJUyOKi1Lw-NJ_HkvCx4qCnAG8PACQFzkTwyqYj1wvRiKEv3Js9ZyBI-BULc_OjpoyXKUKI3agPewJLWPcWo0zKolfFa8Sylg72P4v-A8ThwKM</recordid><startdate>2007</startdate><enddate>2007</enddate><creator>Moreno, S.R.F.</creator><creator>Carvalho, J.J.</creator><creator>Nascimento, A.L.</creator><creator>Pereira, M.</creator><creator>Rocha, E.K.</creator><creator>Olej, B.</creator><creator>Caldas, L.Q.A.</creator><creator>Bernardo-Filho, M.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>2007</creationdate><title>Experimental model to assess possible medicinal herb interaction with a radiobiocomplex: Qualitative and quantitative analysis of kidney, liver and duodenum isolated from treated rats</title><author>Moreno, S.R.F. ; Carvalho, J.J. ; Nascimento, A.L. ; Pereira, M. ; Rocha, E.K. ; Olej, B. ; Caldas, L.Q.A. ; Bernardo-Filho, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-60a417b803f0e3f3a6f3e51543109cfd0c28dfa2f0967200fddafe9f2741a8e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>animal models</topic><topic>Animals</topic><topic>antagonists</topic><topic>antioxidant activity</topic><topic>antioxidants</topic><topic>bioactive properties</topic><topic>Bioavailability</topic><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>Drug Interactions</topic><topic>Duodenum - drug effects</topic><topic>Duodenum - metabolism</topic><topic>Duodenum - pathology</topic><topic>Female</topic><topic>free radicals</topic><topic>G. biloba extract</topic><topic>General pharmacology</topic><topic>Ginkgo biloba</topic><topic>Ginkgo biloba - chemistry</topic><topic>herbal medicines</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Kidney - pathology</topic><topic>Kidney Glomerulus - drug effects</topic><topic>Kidney Glomerulus - pathology</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>Models, Animal</topic><topic>Morphometry</topic><topic>nutrient availability</topic><topic>nutrient-nutrient interactions</topic><topic>nutritive value</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>plant extracts</topic><topic>Plant Extracts - toxicity</topic><topic>platelet-activating factor</topic><topic>Radiobiocomplex</topic><topic>Radiopharmaceuticals - pharmacokinetics</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sodium pertechnetate</topic><topic>Sodium Pertechnetate Tc 99m - pharmacokinetics</topic><topic>Tissue Distribution</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moreno, S.R.F.</creatorcontrib><creatorcontrib>Carvalho, J.J.</creatorcontrib><creatorcontrib>Nascimento, A.L.</creatorcontrib><creatorcontrib>Pereira, M.</creatorcontrib><creatorcontrib>Rocha, E.K.</creatorcontrib><creatorcontrib>Olej, B.</creatorcontrib><creatorcontrib>Caldas, L.Q.A.</creatorcontrib><creatorcontrib>Bernardo-Filho, M.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moreno, S.R.F.</au><au>Carvalho, J.J.</au><au>Nascimento, A.L.</au><au>Pereira, M.</au><au>Rocha, E.K.</au><au>Olej, B.</au><au>Caldas, L.Q.A.</au><au>Bernardo-Filho, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental model to assess possible medicinal herb interaction with a radiobiocomplex: Qualitative and quantitative analysis of kidney, liver and duodenum isolated from treated rats</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>2007</date><risdate>2007</risdate><volume>45</volume><issue>1</issue><spage>19</spage><epage>23</epage><pages>19-23</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>Ginkgo biloba extract (EGb) has been used as a medicinal herb. Several biological properties have been associated with this extract, especially, in the increase of the blood flow, in the action as platelet activating factor antagonism and in the prevention of the membrane against the damage caused by free radicals. Radiobiocomplexes have been utilized in various nuclear medicine procedures helping in the diagnosis and/or treatment of human diseases. Many substances have been reported to affect the bioavailability of different radiobiocomplexes. The aim of this work was to evaluate the possible influence of an EGb on the bioavailability of the sodium pertechnetate (
99mTcO
4Na) and on the morphometry of some organs isolated from rats. These animals were treated with EGb and
99mTcO
4Na was injected. The animals were sacrificed, the organs isolated, counted in a well counter and the percentage of radioactivity per gram of each organ was calculated. The results showed that EGb decreased the uptake of the
99mTcO
4Na in the duodenum (
P
<
0.05). Moreover, morphometric analysis has revealed significant modifications (
P
<
0.05) on kidney, liver and duodenum due to the cited treatment. It is speculated that the substances present in the EGb could act directly or generate metabolites capable to promote changes in organs (kidney, liver and duodenum), however, only significant alteration in the uptake of the
99mTcO
4Na in the duodenum.</abstract><cop>Oxford</cop><cop>New York, NY</cop><pub>Elsevier Ltd</pub><pmid>17052830</pmid><doi>10.1016/j.fct.2006.04.007</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Food and chemical toxicology, 2007, Vol.45 (1), p.19-23 |
| issn | 0278-6915 1873-6351 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | animal models Animals antagonists antioxidant activity antioxidants bioactive properties Bioavailability Biological and medical sciences Biological Availability Drug Interactions Duodenum - drug effects Duodenum - metabolism Duodenum - pathology Female free radicals G. biloba extract General pharmacology Ginkgo biloba Ginkgo biloba - chemistry herbal medicines Kidney - drug effects Kidney - metabolism Kidney - pathology Kidney Glomerulus - drug effects Kidney Glomerulus - pathology Liver - drug effects Liver - metabolism Liver - pathology Medical sciences medicinal plants Models, Animal Morphometry nutrient availability nutrient-nutrient interactions nutritive value Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plant extracts Plant Extracts - toxicity platelet-activating factor Radiobiocomplex Radiopharmaceuticals - pharmacokinetics Rats Rats, Wistar Sodium pertechnetate Sodium Pertechnetate Tc 99m - pharmacokinetics Tissue Distribution Toxicology |
| title | Experimental model to assess possible medicinal herb interaction with a radiobiocomplex: Qualitative and quantitative analysis of kidney, liver and duodenum isolated from treated rats |
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