Mitochondrial targeting sequence of the influenza A virus PB1-F2 protein and its function in mitochondria

The influenza A virus PB1-F2 protein predominantly localizes in the mitochondria of virus-infected cells. A series of cDNAs encoding N- and C-terminal deletion mutants and site-directed mutagenesis of the basic residues of PB1-F2 appended to 3xFLAG revealed the domain from residues 46 to 75 to be bo...

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Veröffentlicht in:	FEBS letters 2004-12, Vol.578 (3), p.331-336
Hauptverfasser:	Yamada, Hiroshi, Chounan, Ritsu, Higashi, Youichirou, Kurihara, Naoki, Kido, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies, Monoclonal - metabolism Arginine - chemistry Benzimidazoles Cell Line Dogs Fluorescein-5-isothiocyanate Fluorescent Dyes HeLa Cells Humans Influenza A virus Influenza A virus - physiology Lysine - chemistry Microscopy, Fluorescence Mitochondria - metabolism Mitochondrial membrane potential Mitochondrion Mutagenesis, Site-Directed PB1-F2 protein Protein Structure, Tertiary Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism Sequence Deletion Targeting sequence Viral Proteins - chemistry Viral Proteins - genetics Viral Proteins - metabolism Viral Proteins - physiology
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