Practical synthesis of novel purine analogues as Hsp90 inhibitors

Practical synthesis of novel purine analogues as Hsp90 inhibitors

The development of a straightforward synthesis of 4-amino-6-benzyl-6 H-pyrrolo[3,4- d]pyrimidine and 7-amino-2-benzyl-2 H-pyrazolo[4,3- d]pyrimidine derivatives allowed for the preparation of a small family of potential Hsp90 inhibitors. Some of the newly synthesized compounds showed Hsp90 inhibitor...

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Veröffentlicht in:Tetrahedron 2008-12, Vol.64 (49), p.11249-11255
Hauptverfasser: Semeraro, Teresa, Mugnaini, Claudia, Manetti, Fabrizio, Pasquini, Serena, Corelli, Federico
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container_end_page 11255
container_issue 49
container_start_page 11249
container_title Tetrahedron
container_volume 64
creator Semeraro, Teresa
Mugnaini, Claudia
Manetti, Fabrizio
Pasquini, Serena
Corelli, Federico
description The development of a straightforward synthesis of 4-amino-6-benzyl-6 H-pyrrolo[3,4- d]pyrimidine and 7-amino-2-benzyl-2 H-pyrazolo[4,3- d]pyrimidine derivatives allowed for the preparation of a small family of potential Hsp90 inhibitors. Some of the newly synthesized compounds showed Hsp90 inhibitory activity in preliminary biological assays. [Display omitted]
doi_str_mv 10.1016/j.tet.2008.09.030
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title Practical synthesis of novel purine analogues as Hsp90 inhibitors
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