G beta gamma Dimers Released in Response to Thyrotropin Activate Phosphoinositide 3-Kinase and Regulate Gene Expression in Thyroid Cells

Signaling by TSH through its receptor leads to the dissociation of trimeric G proteins into G alpha and G beta gamma . G alpha s activates adenylyl cyclase, which increases cAMP levels that induce several effects in the thyroid cell, including transcription of the sodium-iodide symporter (NIS) gene...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2008-05, Vol.22 (5), p.1183-1199
Hauptverfasser:	Zaballos, Miguel A, Garcia, Bibian, Santisteban, Pilar
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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