Influence of genetic polymorphisms of styrene-metabolizing enzymes and smoking habits on levels of urinary metabolites after occupational exposure to styrene

Here we evaluate the influence of individual genetic polymorphisms of drug-metabolizing enzymes as well as body mass index (BMI) and lifestyle (smoking, alcohol consumption) on urinary metabolites after occupational exposure to styrene. Seventy-three workers exposed to styrene in a reinforced-plasti...

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Veröffentlicht in:	Toxicology letters 2005-12, Vol.160 (1), p.84-91
Hauptverfasser:	Ma, Mingyue, Umemura, Tomohiro, Mori, Yuko, Gong, Yingyan, Saijo, Yasuaki, Sata, Fumihiro, Kawai, Toshio, Kishi, Reiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alcohol Drinking - urine Aryl Hydrocarbon Hydroxylases - genetics Aryl Hydrocarbon Hydroxylases - metabolism Biological and medical sciences Biological monitoring Body Mass Index Chemical and industrial products toxicology. Toxic occupational diseases Cytochrome P-450 CYP2B6 Cytochrome P-450 CYP2E1 - genetics Cytochrome P-450 CYP2E1 - metabolism Epoxide Hydrolases - genetics Epoxide Hydrolases - metabolism Genetic polymorphisms Genotype Glutathione S-Transferase pi - genetics Glutathione S-Transferase pi - metabolism Glutathione Transferase - genetics Glutathione Transferase - metabolism Glyoxylates - urine Humans Male Mandelic acid (MA) Mandelic Acids - urine Medical sciences Occupational Exposure - adverse effects Oxidoreductases, N-Demethylating - genetics Oxidoreductases, N-Demethylating - metabolism Phenylglyoxylic acid (PGA) Polymerase Chain Reaction Polymorphism, Genetic Smoking - urine Solvents Styrene Styrene - metabolism Styrene - poisoning Tobacco, tobacco smoking Toxicology
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