Diffusion tensor MRI of early upper motor neuron involvement in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative system disorder affecting both upper and lower motor neurons. Despite supportive electrophysiological investigations, the involvement of the upper motor neuron is often difficult to assess at an early stage of disease. Diffusion...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2004-02, Vol.127 (2), p.340-350
Hauptverfasser:	Sach, Miriam, Winkler, Gerhard, Glauche, Volkmar, Liepert, Joachim, Heimbach, Bernhard, Koch, Martin A., Büchel, Christian, Weiller, Cornelius
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult ALS = amyotrophic lateral sclerosis amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - diagnosis Amyotrophic Lateral Sclerosis - pathology Amyotrophic Lateral Sclerosis - physiopathology Anisotropy Biological and medical sciences CMCT = central motor conduction time corticospinal tract diffusion tensor MRI Disease Progression DTI = diffusion tensor imaging Electromagnetic Fields EPI = echoplanar imaging Evoked Potentials, Motor Female Humans LMN = lower motor neuron Magnetic Resonance Imaging - methods Male Medical sciences MEP = motor evoked potential Middle Aged MNI = Montreal Neurological Institute Motor Neurons - pathology Motor Neurons - physiology Neural Conduction Neurology Regression Analysis ROI = region of interest SNR = signal‐to‐noise ratio STEAM = stimulated echo acquisition mode TMS = transcranial magnetic stimulation transcranial magnetic stimulation UMN = upper motor neuron upper motor neuron
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