Marathon running increases circulating endothelial- and thrombocyte-derived microparticles

Marathon running increases circulating endothelial- and thrombocyte-derived microparticles

Background Acute vascular effects of high intensity physical activity are incompletely characterized. Circulating microparticles are cellular markers for vascular activation and damage. Methods Microparticles were analysed in 99 marathon runners (49 ± 6 years, 22% female) of the prospective Berlin B...

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Veröffentlicht in:European journal of preventive cardiology 2018-02, Vol.25 (3), p.317-324
Hauptverfasser: Schwarz, Viktoria, Düsing, Philip, Liman, Thomas, Werner, Christian, Herm, Juliane, Bachelier, Katrin, Krüll, Matthias, Brechtel, Lars, Jungehulsing, Gerhard J, Haverkamp, Wilhelm, Böhm, Michael, Endres, Matthias, Haeusler, Karl Georg, Laufs, Ulrich
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container_issue 3
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container_title European journal of preventive cardiology
container_volume 25
creator Schwarz, Viktoria
Düsing, Philip
Liman, Thomas
Werner, Christian
Herm, Juliane
Bachelier, Katrin
Krüll, Matthias
Brechtel, Lars
Jungehulsing, Gerhard J
Haverkamp, Wilhelm
Böhm, Michael
Endres, Matthias
Haeusler, Karl Georg
Laufs, Ulrich
description Background Acute vascular effects of high intensity physical activity are incompletely characterized. Circulating microparticles are cellular markers for vascular activation and damage. Methods Microparticles were analysed in 99 marathon runners (49 ± 6 years, 22% female) of the prospective Berlin Beat of Running study. Blood samples were taken within three days before, immediately after and within two days after the marathon run. Endothelial-derived microparticles were labelled with CD144, CD31 and CD62E, platelet-derived microparticles with CD62P and CD42b, leukocyte-derived microparticles with CD45 and monocyte-derived microparticles with CD14. Results Marathon running induced leukocytosis (5.9 ± 0.1 to 14.8 ± 0.3 109/l, p 
doi_str_mv 10.1177/2047487317744364
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Circulating microparticles are cellular markers for vascular activation and damage. Methods Microparticles were analysed in 99 marathon runners (49 ± 6 years, 22% female) of the prospective Berlin Beat of Running study. Blood samples were taken within three days before, immediately after and within two days after the marathon run. Endothelial-derived microparticles were labelled with CD144, CD31 and CD62E, platelet-derived microparticles with CD62P and CD42b, leukocyte-derived microparticles with CD45 and monocyte-derived microparticles with CD14. Results Marathon running induced leukocytosis (5.9 ± 0.1 to 14.8 ± 0.3 109/l, p &lt; 0.0001) and increased platelet counts (239 ± 4.6 to 281 ± 5.9 109/l, p &lt; 0.0001) immediately after the marathon. Blood monocytes increased and lymphocytes decreased after the run (p &lt; 0.0001). Endothelial-derived microparticles were acutely increased (p = 0.008) due to a 23% increase of apoptotic endothelial-derived microparticles (p = 0.007) and returned to baseline within two days after the marathon. Thrombocyte-derived microparticles acutely increased by 38% accompanied by an increase in activated and apoptotic thrombocyte-derived microparticles (p ≤ 0.0001) each. Both monocyte- and leukocyte-derived microparticles were decreased immediately after marathon run (p &lt; 0.0001) and remained below baseline until day 2. Troponin T increased from 12 to 32 ng/l (p &lt; 0.0001) immediately after the run and returned to baseline after two days. Conclusion Circulating apoptotic endothelial- and thrombocyte-derived microparticles increased after marathon running consistent with an acute pro-thrombotic and pro-inflammatory state. Exercise-induced vascular damage reflected by microparticles could indicate potential mechanisms of post-exertional cardiovascular complications. Further studies are warranted to investigate microparticles as markers to identify individuals prone to such complications.</description><identifier>ISSN: 2047-4873</identifier><identifier>EISSN: 2047-4881</identifier><identifier>DOI: 10.1177/2047487317744364</identifier><identifier>PMID: 29183152</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><ispartof>European journal of preventive cardiology, 2018-02, Vol.25 (3), p.317-324</ispartof><rights>The European Society of Cardiology 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-b0e22eaa39346732caf4504191199eda0630f9e38ff5363cdb8f6bbbdf7143803</citedby><cites>FETCH-LOGICAL-c337t-b0e22eaa39346732caf4504191199eda0630f9e38ff5363cdb8f6bbbdf7143803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/2047487317744364$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/2047487317744364$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29183152$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schwarz, Viktoria</creatorcontrib><creatorcontrib>Düsing, Philip</creatorcontrib><creatorcontrib>Liman, Thomas</creatorcontrib><creatorcontrib>Werner, Christian</creatorcontrib><creatorcontrib>Herm, Juliane</creatorcontrib><creatorcontrib>Bachelier, Katrin</creatorcontrib><creatorcontrib>Krüll, Matthias</creatorcontrib><creatorcontrib>Brechtel, Lars</creatorcontrib><creatorcontrib>Jungehulsing, Gerhard J</creatorcontrib><creatorcontrib>Haverkamp, Wilhelm</creatorcontrib><creatorcontrib>Böhm, Michael</creatorcontrib><creatorcontrib>Endres, Matthias</creatorcontrib><creatorcontrib>Haeusler, Karl Georg</creatorcontrib><creatorcontrib>Laufs, Ulrich</creatorcontrib><title>Marathon running increases circulating endothelial- and thrombocyte-derived microparticles</title><title>European journal of preventive cardiology</title><addtitle>Eur J Cardiovasc Prev Rehabil</addtitle><description>Background Acute vascular effects of high intensity physical activity are incompletely characterized. Circulating microparticles are cellular markers for vascular activation and damage. Methods Microparticles were analysed in 99 marathon runners (49 ± 6 years, 22% female) of the prospective Berlin Beat of Running study. Blood samples were taken within three days before, immediately after and within two days after the marathon run. Endothelial-derived microparticles were labelled with CD144, CD31 and CD62E, platelet-derived microparticles with CD62P and CD42b, leukocyte-derived microparticles with CD45 and monocyte-derived microparticles with CD14. Results Marathon running induced leukocytosis (5.9 ± 0.1 to 14.8 ± 0.3 109/l, p &lt; 0.0001) and increased platelet counts (239 ± 4.6 to 281 ± 5.9 109/l, p &lt; 0.0001) immediately after the marathon. Blood monocytes increased and lymphocytes decreased after the run (p &lt; 0.0001). Endothelial-derived microparticles were acutely increased (p = 0.008) due to a 23% increase of apoptotic endothelial-derived microparticles (p = 0.007) and returned to baseline within two days after the marathon. Thrombocyte-derived microparticles acutely increased by 38% accompanied by an increase in activated and apoptotic thrombocyte-derived microparticles (p ≤ 0.0001) each. Both monocyte- and leukocyte-derived microparticles were decreased immediately after marathon run (p &lt; 0.0001) and remained below baseline until day 2. Troponin T increased from 12 to 32 ng/l (p &lt; 0.0001) immediately after the run and returned to baseline after two days. Conclusion Circulating apoptotic endothelial- and thrombocyte-derived microparticles increased after marathon running consistent with an acute pro-thrombotic and pro-inflammatory state. Exercise-induced vascular damage reflected by microparticles could indicate potential mechanisms of post-exertional cardiovascular complications. 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Circulating microparticles are cellular markers for vascular activation and damage. Methods Microparticles were analysed in 99 marathon runners (49 ± 6 years, 22% female) of the prospective Berlin Beat of Running study. Blood samples were taken within three days before, immediately after and within two days after the marathon run. Endothelial-derived microparticles were labelled with CD144, CD31 and CD62E, platelet-derived microparticles with CD62P and CD42b, leukocyte-derived microparticles with CD45 and monocyte-derived microparticles with CD14. Results Marathon running induced leukocytosis (5.9 ± 0.1 to 14.8 ± 0.3 109/l, p &lt; 0.0001) and increased platelet counts (239 ± 4.6 to 281 ± 5.9 109/l, p &lt; 0.0001) immediately after the marathon. Blood monocytes increased and lymphocytes decreased after the run (p &lt; 0.0001). Endothelial-derived microparticles were acutely increased (p = 0.008) due to a 23% increase of apoptotic endothelial-derived microparticles (p = 0.007) and returned to baseline within two days after the marathon. Thrombocyte-derived microparticles acutely increased by 38% accompanied by an increase in activated and apoptotic thrombocyte-derived microparticles (p ≤ 0.0001) each. Both monocyte- and leukocyte-derived microparticles were decreased immediately after marathon run (p &lt; 0.0001) and remained below baseline until day 2. Troponin T increased from 12 to 32 ng/l (p &lt; 0.0001) immediately after the run and returned to baseline after two days. Conclusion Circulating apoptotic endothelial- and thrombocyte-derived microparticles increased after marathon running consistent with an acute pro-thrombotic and pro-inflammatory state. Exercise-induced vascular damage reflected by microparticles could indicate potential mechanisms of post-exertional cardiovascular complications. Further studies are warranted to investigate microparticles as markers to identify individuals prone to such complications.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>29183152</pmid><doi>10.1177/2047487317744364</doi><tpages>8</tpages></addata></record>
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title Marathon running increases circulating endothelial- and thrombocyte-derived microparticles
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