Synthesis of 4,5-Diazaspiro[2.3]hexanes and 1,2-Diazaspiro[3.3]heptanes as Hexahydropyridazine Analogues

4,5-Diazaspiro­[2.3]­hexanes are made by dihalocarbene addition across the exocyclic double bond of readily accessible 3-alkylidene-1,2-diazetidines. Using difluorocarbene, generated from TMSCF3/NaI, these spirocycles were produced in yields up to 97% by stereospecific addition across the alkene. Lo...

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Veröffentlicht in:	Journal of organic chemistry 2018-01, Vol.83 (1), p.491-498
Hauptverfasser:	Pancholi, Alpa K, Iacobini, Greg P, Clarkson, Guy J, Porter, David W, Shipman, Michael
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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