Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases
Studies show that the plant polyphenol resveratrol can extend the life span of yeast, worms, flies, and fish. It also mitigates the metabolic dysfunction of mice fed high-fat diets. Resveratrol appears to mediate these effects partly by activating SIRT1, a deacetylase enzyme that regulates the activ...
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| Veröffentlicht in: | Nutrition reviews 2008-10, Vol.66 (10), p.591-596 |
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| creator | Knutson, Mitchell D Leeuwenburgh, Christiaan |
| description | Studies show that the plant polyphenol resveratrol can extend the life span of yeast, worms, flies, and fish. It also mitigates the metabolic dysfunction of mice fed high-fat diets. Resveratrol appears to mediate these effects partly by activating SIRT1, a deacetylase enzyme that regulates the activity of several transcriptional factors and enzymes responsive to nutrient availability. However, few foods contain resveratrol and humans metabolize it extensively, resulting in very low systemic bioavailability. Substantial research effort now focuses on identifying and testing more bioavailable and potent activators of SIRT1 for use as pharmacologic interventions in aging and age-related disorders. |
| doi_str_mv | 10.1111/j.1753-4887.2008.00109.x |
| format | Article |
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It also mitigates the metabolic dysfunction of mice fed high-fat diets. Resveratrol appears to mediate these effects partly by activating SIRT1, a deacetylase enzyme that regulates the activity of several transcriptional factors and enzymes responsive to nutrient availability. However, few foods contain resveratrol and humans metabolize it extensively, resulting in very low systemic bioavailability. Substantial research effort now focuses on identifying and testing more bioavailable and potent activators of SIRT1 for use as pharmacologic interventions in aging and age-related disorders.</description><identifier>ISSN: 0029-6643</identifier><identifier>EISSN: 1753-4887</identifier><identifier>DOI: 10.1111/j.1753-4887.2008.00109.x</identifier><identifier>PMID: 18826454</identifier><identifier>CODEN: NUREA8</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>age ; Aging ; animal age ; animal proteins ; Animals ; bioavailability ; Biological and medical sciences ; Biological Availability ; Cardiovascular Diseases - drug therapy ; Diabetes Mellitus, Type 2 - drug therapy ; Drugs ; enzyme activation ; Enzyme Activation - drug effects ; Enzyme Activators - pharmacology ; Enzyme Activators - toxicity ; Enzymes ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; Humans ; hydrolases ; Inflammation - drug therapy ; laboratory animals ; life span ; literature reviews ; longevity ; metabolism ; Neurodegenerative Diseases - drug therapy ; noninfectious diseases ; nutrient availability ; Pharmacology ; polyphenol ; red wine ; resveratrol ; Rodents ; senescence ; sirtuin ; Sirtuin 1 ; Sirtuins - drug effects ; Sirtuins - physiology ; Stilbenes - pharmacokinetics ; Stilbenes - pharmacology ; Stilbenes - therapeutic use ; Studies ; transcription factors ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Wines ; yeasts</subject><ispartof>Nutrition reviews, 2008-10, Vol.66 (10), p.591-596</ispartof><rights>2008 International Life Sciences Institute</rights><rights>2009 INIST-CNRS</rights><rights>Copyright International Life Sciences Institute Oct 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5349-bfa5d0fecab23fce5e26cb0441d7d3a0a78f2e1bacb01acdb12d568ef2dc166b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1753-4887.2008.00109.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1753-4887.2008.00109.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20742725$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18826454$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Knutson, Mitchell D</creatorcontrib><creatorcontrib>Leeuwenburgh, Christiaan</creatorcontrib><title>Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases</title><title>Nutrition reviews</title><addtitle>Nutr Rev</addtitle><description>Studies show that the plant polyphenol resveratrol can extend the life span of yeast, worms, flies, and fish. It also mitigates the metabolic dysfunction of mice fed high-fat diets. Resveratrol appears to mediate these effects partly by activating SIRT1, a deacetylase enzyme that regulates the activity of several transcriptional factors and enzymes responsive to nutrient availability. However, few foods contain resveratrol and humans metabolize it extensively, resulting in very low systemic bioavailability. Substantial research effort now focuses on identifying and testing more bioavailable and potent activators of SIRT1 for use as pharmacologic interventions in aging and age-related disorders.</description><subject>age</subject><subject>Aging</subject><subject>animal age</subject><subject>animal proteins</subject><subject>Animals</subject><subject>bioavailability</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>Cardiovascular Diseases - drug therapy</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Drugs</subject><subject>enzyme activation</subject><subject>Enzyme Activation - drug effects</subject><subject>Enzyme Activators - pharmacology</subject><subject>Enzyme Activators - toxicity</subject><subject>Enzymes</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>hydrolases</subject><subject>Inflammation - drug therapy</subject><subject>laboratory animals</subject><subject>life span</subject><subject>literature reviews</subject><subject>longevity</subject><subject>metabolism</subject><subject>Neurodegenerative Diseases - drug therapy</subject><subject>noninfectious diseases</subject><subject>nutrient availability</subject><subject>Pharmacology</subject><subject>polyphenol</subject><subject>red wine</subject><subject>resveratrol</subject><subject>Rodents</subject><subject>senescence</subject><subject>sirtuin</subject><subject>Sirtuin 1</subject><subject>Sirtuins - drug effects</subject><subject>Sirtuins - physiology</subject><subject>Stilbenes - pharmacokinetics</subject><subject>Stilbenes - pharmacology</subject><subject>Stilbenes - therapeutic use</subject><subject>Studies</subject><subject>transcription factors</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Wines</subject><subject>yeasts</subject><issn>0029-6643</issn><issn>1753-4887</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkd1uEzEQhS0EoqHwCmAh0bsN_lvbi8QFaksplCKljZDgwprdHUebbnaDvQnp2-M0IUj4ZqyZ7xyN5hBCORvz9N7Ox9zkMlPWmrFgzI4Z46wYbx6R0WHwmIwYE0WmtZJH5FmMc5YoUcin5IhbK7TK1Yj8nGBcY4Ah9C2FrqZdv8aWLvsBu4FCNTRrGPoQae_pzeXklr-j6D1WQ-p0FGZNN3uQwQyzgC0MWNO6iQgR43PyxEMb8cW-HpPpx_Pb00_Z1beLy9MPV1mVS1VkpYe8ZskTSiF9hTkKXZVMKV6bWgIDY71AXkJqcqjqkos61xa9qCuudSmPycnOdxn6XyuMg1s0scK2hQ77VXS8MOk8RiTw9X_gvF-FLu3mBBdSaaGKBL3cQ6tygbVbhmYB4d79vVkC3uwBiBW0PkBXNfHACWaUMCJP3Psd97tp8f6fD3PbDN3cbaNy26jcNkP3kKHbuOvp5Dz9kj7b6Zs44Oagh3DntJEmd9-vL1zOf3wuvtoz9yXxr3a8h97BLKSdpjeCccl4bi3XVv4Byj-nqw</recordid><startdate>200810</startdate><enddate>200810</enddate><creator>Knutson, Mitchell D</creator><creator>Leeuwenburgh, Christiaan</creator><general>Blackwell Publishing Inc</general><general>Wiley</general><general>Oxford University Press</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7TV</scope><scope>C1K</scope></search><sort><creationdate>200810</creationdate><title>Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases</title><author>Knutson, Mitchell D ; Leeuwenburgh, Christiaan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5349-bfa5d0fecab23fce5e26cb0441d7d3a0a78f2e1bacb01acdb12d568ef2dc166b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>age</topic><topic>Aging</topic><topic>animal age</topic><topic>animal proteins</topic><topic>Animals</topic><topic>bioavailability</topic><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>Cardiovascular Diseases - drug therapy</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Drugs</topic><topic>enzyme activation</topic><topic>Enzyme Activation - drug effects</topic><topic>Enzyme Activators - pharmacology</topic><topic>Enzyme Activators - toxicity</topic><topic>Enzymes</topic><topic>Feeding. Feeding behavior</topic><topic>Fundamental and applied biological sciences. 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It also mitigates the metabolic dysfunction of mice fed high-fat diets. Resveratrol appears to mediate these effects partly by activating SIRT1, a deacetylase enzyme that regulates the activity of several transcriptional factors and enzymes responsive to nutrient availability. However, few foods contain resveratrol and humans metabolize it extensively, resulting in very low systemic bioavailability. Substantial research effort now focuses on identifying and testing more bioavailable and potent activators of SIRT1 for use as pharmacologic interventions in aging and age-related disorders.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>18826454</pmid><doi>10.1111/j.1753-4887.2008.00109.x</doi><tpages>6</tpages></addata></record> |
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| subjects | age Aging animal age animal proteins Animals bioavailability Biological and medical sciences Biological Availability Cardiovascular Diseases - drug therapy Diabetes Mellitus, Type 2 - drug therapy Drugs enzyme activation Enzyme Activation - drug effects Enzyme Activators - pharmacology Enzyme Activators - toxicity Enzymes Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Humans hydrolases Inflammation - drug therapy laboratory animals life span literature reviews longevity metabolism Neurodegenerative Diseases - drug therapy noninfectious diseases nutrient availability Pharmacology polyphenol red wine resveratrol Rodents senescence sirtuin Sirtuin 1 Sirtuins - drug effects Sirtuins - physiology Stilbenes - pharmacokinetics Stilbenes - pharmacology Stilbenes - therapeutic use Studies transcription factors Vertebrates: anatomy and physiology, studies on body, several organs or systems Wines yeasts |
| title | Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases |
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