Positive inotropic effect of the leaf extracts of parent and tissue culture plants of Coleus amboinicus on an isolated perfused frog heart preparation
The leaves of the indigenous plant Coleus amboinicus Lour (Lamiaceae) possess a characteristic aroma and are used in many food preparations to enhance the flavour. Apart from this, they also exhibit medicinal properties. Aqueous extracts of fresh leaves of C. amboinicus Lour. parent (CAP), as well a...
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| Veröffentlicht in: | Food chemistry 2009-05, Vol.114 (1), p.139-141 |
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| creator | Hole, R.C. Juvekar, A.R. Roja, G. Eapen, Susan D’Souza, S.F. |
| description | The leaves of the indigenous plant
Coleus amboinicus Lour (Lamiaceae) possess a characteristic aroma and are used in many food preparations to enhance the flavour. Apart from this, they also exhibit medicinal properties. Aqueous extracts of fresh leaves of
C. amboinicus Lour. parent (CAP), as well as tissue culture-raised plants (CAT), showed a dose-dependent positive inotropic effect on isolated frog heart. The extracts of CAT showed higher activity. The responses to CAP and CAT (50–800
μg) were not affected in either way by propranolol, atropine, verapamil or imidazole. The responses to both CAP and CAT were inhibited after lowering sodium chloride concentration (from 111 to 55.6
mM) and potentiated after increasing sodium chloride concentration (from 111 to 222
mM). Lignocaine was found to inhibit the responses significantly. Thus,
C. amboinicus induces a positive inotropic effect, possibly by increasing sodium influx, leading to greater intracellular availability of calcium. |
| doi_str_mv | 10.1016/j.foodchem.2008.09.047 |
| format | Article |
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Coleus amboinicus Lour (Lamiaceae) possess a characteristic aroma and are used in many food preparations to enhance the flavour. Apart from this, they also exhibit medicinal properties. Aqueous extracts of fresh leaves of
C. amboinicus Lour. parent (CAP), as well as tissue culture-raised plants (CAT), showed a dose-dependent positive inotropic effect on isolated frog heart. The extracts of CAT showed higher activity. The responses to CAP and CAT (50–800
μg) were not affected in either way by propranolol, atropine, verapamil or imidazole. The responses to both CAP and CAT were inhibited after lowering sodium chloride concentration (from 111 to 55.6
mM) and potentiated after increasing sodium chloride concentration (from 111 to 222
mM). Lignocaine was found to inhibit the responses significantly. Thus,
C. amboinicus induces a positive inotropic effect, possibly by increasing sodium influx, leading to greater intracellular availability of calcium.</description><identifier>ISSN: 0308-8146</identifier><identifier>EISSN: 1873-7072</identifier><identifier>DOI: 10.1016/j.foodchem.2008.09.047</identifier><language>eng</language><publisher>Elsevier Ltd</publisher><subject>bioactive properties ; calcium ; Coleus amboinicus ; frogs ; heart ; inotropic effect ; leaves ; medicinal plants ; muscle physiology ; nutrition physiology ; plant extracts ; plant tissues ; Plectranthus ; Positive inotropic effect ; sodium ; Tissue culture</subject><ispartof>Food chemistry, 2009-05, Vol.114 (1), p.139-141</ispartof><rights>2008 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c367t-2f641211e6d2cc18291bf0431b684f3fccfa1c3711278f5208dddd0d8fc35d213</citedby><cites>FETCH-LOGICAL-c367t-2f641211e6d2cc18291bf0431b684f3fccfa1c3711278f5208dddd0d8fc35d213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.foodchem.2008.09.047$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids></links><search><creatorcontrib>Hole, R.C.</creatorcontrib><creatorcontrib>Juvekar, A.R.</creatorcontrib><creatorcontrib>Roja, G.</creatorcontrib><creatorcontrib>Eapen, Susan</creatorcontrib><creatorcontrib>D’Souza, S.F.</creatorcontrib><title>Positive inotropic effect of the leaf extracts of parent and tissue culture plants of Coleus amboinicus on an isolated perfused frog heart preparation</title><title>Food chemistry</title><description>The leaves of the indigenous plant
Coleus amboinicus Lour (Lamiaceae) possess a characteristic aroma and are used in many food preparations to enhance the flavour. Apart from this, they also exhibit medicinal properties. Aqueous extracts of fresh leaves of
C. amboinicus Lour. parent (CAP), as well as tissue culture-raised plants (CAT), showed a dose-dependent positive inotropic effect on isolated frog heart. The extracts of CAT showed higher activity. The responses to CAP and CAT (50–800
μg) were not affected in either way by propranolol, atropine, verapamil or imidazole. The responses to both CAP and CAT were inhibited after lowering sodium chloride concentration (from 111 to 55.6
mM) and potentiated after increasing sodium chloride concentration (from 111 to 222
mM). Lignocaine was found to inhibit the responses significantly. Thus,
C. amboinicus induces a positive inotropic effect, possibly by increasing sodium influx, leading to greater intracellular availability of calcium.</description><subject>bioactive properties</subject><subject>calcium</subject><subject>Coleus amboinicus</subject><subject>frogs</subject><subject>heart</subject><subject>inotropic effect</subject><subject>leaves</subject><subject>medicinal plants</subject><subject>muscle physiology</subject><subject>nutrition physiology</subject><subject>plant extracts</subject><subject>plant tissues</subject><subject>Plectranthus</subject><subject>Positive inotropic effect</subject><subject>sodium</subject><subject>Tissue culture</subject><issn>0308-8146</issn><issn>1873-7072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqFkc-OFCEQh4nRxHF3X0E5eeu2Cnq6mZtm4r9kE03cPRMGih0mPU0L9MZ9EZ9XJq1nuVAh368qxcfYa4QWAft3p9bH6OyRzq0AUC3sWuiGZ2yDapDNAIN4zjYgQTUKu_4le5XzCQAEoNqw399jDiU8Eg9TLCnOwXLynmzh0fNyJD6S8Zx-lWRsyZfH2SSaCjeT4yXkvBC3y1iWRHwezbQy-zjSkrk5H2KYgq1lnGqChxxHU8jxmZJfci18ig_8SCYVPieqvU0JcbpmL7wZM938va_Y_aePd_svze23z1_3H24bK_uhNML3HQpE6p2wFpXY4cFDJ_HQq85Lb603aOWAKAbltwKUqwec8lZunUB5xd6ufecUfy6Uiz6HbGmsi1BcssbdANB1ooL9CtoUc07k9ZzC2aQnjaAvGvRJ_9OgLxo07HTVUINv1qA3UZuHFLK-_1H_XgJuFQq4EO9Xguqij4GSzjbQZMmFVD1oF8P_hvwBbWShUg</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>Hole, R.C.</creator><creator>Juvekar, A.R.</creator><creator>Roja, G.</creator><creator>Eapen, Susan</creator><creator>D’Souza, S.F.</creator><general>Elsevier Ltd</general><general>[Amsterdam]: Elsevier Science</general><scope>FBQ</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope></search><sort><creationdate>20090501</creationdate><title>Positive inotropic effect of the leaf extracts of parent and tissue culture plants of Coleus amboinicus on an isolated perfused frog heart preparation</title><author>Hole, R.C. ; Juvekar, A.R. ; Roja, G. ; Eapen, Susan ; D’Souza, S.F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-2f641211e6d2cc18291bf0431b684f3fccfa1c3711278f5208dddd0d8fc35d213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>bioactive properties</topic><topic>calcium</topic><topic>Coleus amboinicus</topic><topic>frogs</topic><topic>heart</topic><topic>inotropic effect</topic><topic>leaves</topic><topic>medicinal plants</topic><topic>muscle physiology</topic><topic>nutrition physiology</topic><topic>plant extracts</topic><topic>plant tissues</topic><topic>Plectranthus</topic><topic>Positive inotropic effect</topic><topic>sodium</topic><topic>Tissue culture</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hole, R.C.</creatorcontrib><creatorcontrib>Juvekar, A.R.</creatorcontrib><creatorcontrib>Roja, G.</creatorcontrib><creatorcontrib>Eapen, Susan</creatorcontrib><creatorcontrib>D’Souza, S.F.</creatorcontrib><collection>AGRIS</collection><collection>CrossRef</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>Food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hole, R.C.</au><au>Juvekar, A.R.</au><au>Roja, G.</au><au>Eapen, Susan</au><au>D’Souza, S.F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Positive inotropic effect of the leaf extracts of parent and tissue culture plants of Coleus amboinicus on an isolated perfused frog heart preparation</atitle><jtitle>Food chemistry</jtitle><date>2009-05-01</date><risdate>2009</risdate><volume>114</volume><issue>1</issue><spage>139</spage><epage>141</epage><pages>139-141</pages><issn>0308-8146</issn><eissn>1873-7072</eissn><abstract>The leaves of the indigenous plant
Coleus amboinicus Lour (Lamiaceae) possess a characteristic aroma and are used in many food preparations to enhance the flavour. Apart from this, they also exhibit medicinal properties. Aqueous extracts of fresh leaves of
C. amboinicus Lour. parent (CAP), as well as tissue culture-raised plants (CAT), showed a dose-dependent positive inotropic effect on isolated frog heart. The extracts of CAT showed higher activity. The responses to CAP and CAT (50–800
μg) were not affected in either way by propranolol, atropine, verapamil or imidazole. The responses to both CAP and CAT were inhibited after lowering sodium chloride concentration (from 111 to 55.6
mM) and potentiated after increasing sodium chloride concentration (from 111 to 222
mM). Lignocaine was found to inhibit the responses significantly. Thus,
C. amboinicus induces a positive inotropic effect, possibly by increasing sodium influx, leading to greater intracellular availability of calcium.</abstract><pub>Elsevier Ltd</pub><doi>10.1016/j.foodchem.2008.09.047</doi><tpages>3</tpages></addata></record> |
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| ispartof | Food chemistry, 2009-05, Vol.114 (1), p.139-141 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | bioactive properties calcium Coleus amboinicus frogs heart inotropic effect leaves medicinal plants muscle physiology nutrition physiology plant extracts plant tissues Plectranthus Positive inotropic effect sodium Tissue culture |
| title | Positive inotropic effect of the leaf extracts of parent and tissue culture plants of Coleus amboinicus on an isolated perfused frog heart preparation |
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