Environmental lead exposure during early life alters granule cell neurogenesis and morphology in the hippocampus of young adult rats

Abstract Exposure to environmentally relevant levels of lead (Pb2+ ) during early life produces deficits in hippocampal synaptic plasticity in the form of long-term potentiation (LTP) and spatial learning in young adult rats [Nihei MK, Desmond NL, McGlothan JL, Kuhlmann AC, Guilarte TR (2000) N-meth...

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Veröffentlicht in:	Neuroscience 2007-03, Vol.145 (3), p.1037-1047
Hauptverfasser:	Verina, T, Rohde, C.A, Guilarte, T.R
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Biological and medical sciences Brain - drug effects Brain - growth & development Brain - physiology Bromodeoxyuridine - pharmacology Environmental Exposure Female Fundamental and applied biological sciences. Psychology granule cell hippocampus Hippocampus - drug effects Hippocampus - growth & development Lead Poisoning - physiopathology morphology Nerve Fibers - physiology neurogenesis Neurology Neurons - drug effects Neurons - physiology neurotoxicity Pb 2 Phenotype Rats Rats, Inbred Lew Vertebrates: nervous system and sense organs
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