Valproate Is Associated with New-Onset Oligoamenorrhea with Hyperandrogenism in Women with Bipolar Disorder

Preliminary evidence suggests that valproate is associated with isolated features of polycystic ovarian syndrome (PCOS), while contradictory data support an association between epilepsy and PCOS. The development of PCOS features after initiation of valproate was therefore examined in women with bipo...

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Veröffentlicht in:	Biological psychiatry (1969) 2006-06, Vol.59 (11), p.1078-1086
Hauptverfasser:	Joffe, Hadine, Cohen, Lee S., Suppes, Trisha, McLaughlin, Wren L., Lavori, Philip, Adams, Judith M., Hwang, Cindy H., Hall, Janet E., Sachs, Gary S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Adult and adolescent clinical studies adverse events Amenorrhea - chemically induced Amenorrhea - epidemiology Antimanic Agents - adverse effects Biological and medical sciences Bipolar disorder Bipolar Disorder - drug therapy Bipolar disorders Cohort Studies Comorbidity Female Humans Hyperandrogenism - chemically induced Hyperandrogenism - epidemiology Incidence Longitudinal Studies Medical sciences Middle Aged Mood disorders Neuropharmacology Oligomenorrhea - chemically induced Oligomenorrhea - epidemiology Pharmacology. Drug treatments polycystic ovarian syndrome Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Risk Factors Time Factors valproate Valproic Acid - adverse effects women
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