Alpha7 nicotinic acetylcholine receptor-specific agonist DMXBA (GTS-21) attenuates Aβ accumulation through suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis and ameliorates cognitive impairment in a mouse model of Alzheimer's disease

We previously demonstrated that stimulation of nicotinic acetylcholine receptors (nAChRs) increases amyloid-β (Aβ) phagocytosis in rat microglia and is closely associated with the decrease of brain Aβ and amelioration of memory dysfunction in a transgenic mouse model of Alzheimer's disease (AD)...

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Veröffentlicht in:	Neurobiology of aging 2018-02, Vol.62, p.197-209
Hauptverfasser:	Takata, Kazuyuki, Amamiya, Takahide, Mizoguchi, Hiroaki, Kawanishi, Shohei, Kuroda, Eriko, Kitamura, Risa, Ito, Aina, Saito, Yuki, Tawa, Manami, Nagasawa, Tomofumi, Okamoto, Haruka, Sugino, Yuko, Takegami, Shigehiko, Kitade, Tatsuya, Toda, Yuki, Kem, William R., Kitamura, Yoshihisa, Shimohama, Shun, Ashihara, Eishi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid-β Microglia Neuron Phagocytosis α7 Nicotinic acetylcholine receptor γ-Secretase
Online-Zugang:	Volltext
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