Asymmetric Synthesis of 2H‐Azirines with a Tetrasubstituted Stereocenter by Enantioselective Ring Contraction of Isoxazoles

Highly strained 2H‐azirines with a tetrasubstituted stereocenter were synthesized by the enantioselective isomerization of isoxazoles with a chiral diene–rhodium catalyst system. The effect of ligands and the coordination behavior support the proposed catalytic cycle in which the coordination site i...

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Veröffentlicht in:	Angewandte Chemie International Edition 2018-01, Vol.57 (4), p.1039-1043
Hauptverfasser:	Okamoto, Kazuhiro, Nanya, Atsushi, Eguchi, Akira, Ohe, Kouichi
Format:	Artikel
Sprache:	eng
Schlagworte:	2H-azirines Asymmetric synthesis Catalysis Chemical synthesis chiral diene ligands Contraction Enantiomers Isomerization isoxazoles Ligands nitrogen heterocycles Rhodium rhodium catalysis
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