3D aggregate culture improves metabolic maturation of human pluripotent stem cell derived cardiomyocytes

Three‐dimensional (3D) cultures of human pluripotent stem cell derived cardiomyocytes (hPSC‐CMs) hold great promise for drug discovery, providing a better approximation to the in vivo physiology over standard two‐dimensional (2D) monolayer cultures. However, the transition of CM differentiation prot...

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Veröffentlicht in:	Biotechnology and bioengineering 2018-03, Vol.115 (3), p.630-644
Hauptverfasser:	Correia, Cláudia, Koshkin, Alexey, Duarte, Patrícia, Hu, Dongjian, Carido, Madalena, Sebastião, Maria J., Gomes‐Alves, Patrícia, Elliott, David A., Domian, Ibrahim J., Teixeira, Ana P., Alves, Paula M., Serra, Margarida
Format:	Artikel
Sprache:	eng
Schlagworte:	3D aggregates Biosynthesis Cardiomyocytes Cell culture Cell Culture Techniques - methods Cell Line Fatty acids Fluxes fluxome Gene expression Gene regulation Genes Glucose Glycolysis Heart diseases Human Embryonic Stem Cells - cytology Human Embryonic Stem Cells - metabolism human pluripotent stem cell‐derived cardiomyocytes (hPSC‐CMs) Humans Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Lipid Metabolism Maturation Metabolic flux metabolic maturation Metabolism Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Oxidative Phosphorylation Pluripotency Stem cells transcriptome
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