Effect of the Natural Cytokine Complex on the Structure and Metabolism of Contractile Myocardium Normally and under Increased Hemodynamic Load
Effect of natural complex of cytokines with activity of IL-1, IL-2, IL-6, TNF, MIF, GTFβ on the structure and metabolism of contractile ventricular cardiomyocytes was assessed in the control and under conditions of acute experimental aortic stenosis. Systemic administration of the complex in the con...
Gespeichert in:
| Veröffentlicht in: | Bulletin of experimental biology and medicine 2017-12, Vol.164 (2), p.136-139 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 139 |
|---|---|
| container_issue | 2 |
| container_start_page | 136 |
| container_title | Bulletin of experimental biology and medicine |
| container_volume | 164 |
| creator | Tverskaya, M. S. Gankovskaya, L. V. Sukhoparova, V. V. Virganskii, A. O. |
| description | Effect of natural complex of cytokines with activity of IL-1, IL-2, IL-6, TNF, MIF, GTFβ on the structure and metabolism of contractile ventricular cardiomyocytes was assessed in the control and under conditions of acute experimental aortic stenosis. Systemic administration of the complex in the control had no significant effect on myocardial morphology with low number of damaged cardiomyocytes and low degree of structural damage. Administration of the cytokine complex against the background of aortic stenosis did not exert any additional alterative effect on cardiomyocytes, structural damage of contractual nature was moderate. Systemic administration of the natural cytokine complex had a pronounced inhibitory effect on metabolic processes in the myocardium of both ventricles both in the control and against the background of increased hemodynamic load. In cardiomyocytes, glycolysis and citric acid cycle were slowed down, oxidation of free fatty acids and their metabolic products was inhibited as well as shuttle mechanisms and biosynthetic reactions. Inhibition of energy-producing processes is the cause of the lack of the contractile function energy supply and can worsen the course of cardiovascular diseases and increase the risk of their complications in conditions, accompanied by increased blood cytokine level. |
| doi_str_mv | 10.1007/s10517-017-3942-4 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1969935221</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A525184703</galeid><sourcerecordid>A525184703</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-e9ab259e3848dd93921bf5be239ae19a86a9a0f1d2a0c9199e1cd2fded679553</originalsourceid><addsrcrecordid>eNp1ktFqFDEUhgdR7Fp9AG8kIIg3U5PMZCe5LEu1hW29sPfhbHKmOzWTrEkG3Jfwmc10q7aihBDC-f7DOT9_Vb1m9IRR2n1IjArW1bTcRrW8bp9UCya6ppacs6fVghaobqWUR9WLlG7nL12y59URV6zrpOSL6sdZ36PJJPQkb5FcQZ4iOLLa5_B18EhWYdw5_E6Cv6t_yXEyBUEC3pJLzLAJbkjjrF8FnyOYPDgkl_tgINphGslViCM4t79TTN5iJBfeRISElpzjGOzewzgYsg5gX1bPenAJX92_x9X1x7Pr1Xm9_vzpYnW6rk3b0Vyjgg0XChvZSmtVozjb9GKDvFGATIFcggLaM8uBGsWUQmYs7y3aZaeEaI6r94e2uxi-TZiyHodk0DnwGKakmVoq1YjiYkHf_oXehin6MtxMSa5EK-Qf6gYc6sH3YbZibqpPBRdMlrGbQp38gyrHYjEgeOyLd48F7x4Itggub1NwUx6CT49BdgBNDClF7PUuDiPEvWZUz1nRh6zokhU9Z0W3RfPmfrNpM6L9rfgVjgLwA5BKyd9gfLD6f7v-BPyvyKM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1968295458</pqid></control><display><type>article</type><title>Effect of the Natural Cytokine Complex on the Structure and Metabolism of Contractile Myocardium Normally and under Increased Hemodynamic Load</title><source>SpringerLink Journals</source><creator>Tverskaya, M. S. ; Gankovskaya, L. V. ; Sukhoparova, V. V. ; Virganskii, A. O.</creator><creatorcontrib>Tverskaya, M. S. ; Gankovskaya, L. V. ; Sukhoparova, V. V. ; Virganskii, A. O.</creatorcontrib><description>Effect of natural complex of cytokines with activity of IL-1, IL-2, IL-6, TNF, MIF, GTFβ on the structure and metabolism of contractile ventricular cardiomyocytes was assessed in the control and under conditions of acute experimental aortic stenosis. Systemic administration of the complex in the control had no significant effect on myocardial morphology with low number of damaged cardiomyocytes and low degree of structural damage. Administration of the cytokine complex against the background of aortic stenosis did not exert any additional alterative effect on cardiomyocytes, structural damage of contractual nature was moderate. Systemic administration of the natural cytokine complex had a pronounced inhibitory effect on metabolic processes in the myocardium of both ventricles both in the control and against the background of increased hemodynamic load. In cardiomyocytes, glycolysis and citric acid cycle were slowed down, oxidation of free fatty acids and their metabolic products was inhibited as well as shuttle mechanisms and biosynthetic reactions. Inhibition of energy-producing processes is the cause of the lack of the contractile function energy supply and can worsen the course of cardiovascular diseases and increase the risk of their complications in conditions, accompanied by increased blood cytokine level.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-017-3942-4</identifier><identifier>PMID: 29177882</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Aortic stenosis ; Aortic valve stenosis ; Biomedical and Life Sciences ; Biomedicine ; Cardiomyocytes ; Cardiovascular diseases ; Cell Biology ; Citric acid ; Contractility ; Cytokines ; Fatty acids ; Glucose metabolism ; Glycolysis ; Interleukin 1 ; Interleukin 2 ; Interleukin 6 ; Internal Medicine ; Laboratory Medicine ; Metabolism ; Myocardium ; Oxidation ; Pathology ; Physiological aspects ; Stenosis ; Tricarboxylic acid cycle ; Ventricle</subject><ispartof>Bulletin of experimental biology and medicine, 2017-12, Vol.164 (2), p.136-139</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2017</rights><rights>COPYRIGHT 2017 Springer</rights><rights>Bulletin of Experimental Biology and Medicine is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-e9ab259e3848dd93921bf5be239ae19a86a9a0f1d2a0c9199e1cd2fded679553</citedby><cites>FETCH-LOGICAL-c470t-e9ab259e3848dd93921bf5be239ae19a86a9a0f1d2a0c9199e1cd2fded679553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-017-3942-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-017-3942-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29177882$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tverskaya, M. S.</creatorcontrib><creatorcontrib>Gankovskaya, L. V.</creatorcontrib><creatorcontrib>Sukhoparova, V. V.</creatorcontrib><creatorcontrib>Virganskii, A. O.</creatorcontrib><title>Effect of the Natural Cytokine Complex on the Structure and Metabolism of Contractile Myocardium Normally and under Increased Hemodynamic Load</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>Effect of natural complex of cytokines with activity of IL-1, IL-2, IL-6, TNF, MIF, GTFβ on the structure and metabolism of contractile ventricular cardiomyocytes was assessed in the control and under conditions of acute experimental aortic stenosis. Systemic administration of the complex in the control had no significant effect on myocardial morphology with low number of damaged cardiomyocytes and low degree of structural damage. Administration of the cytokine complex against the background of aortic stenosis did not exert any additional alterative effect on cardiomyocytes, structural damage of contractual nature was moderate. Systemic administration of the natural cytokine complex had a pronounced inhibitory effect on metabolic processes in the myocardium of both ventricles both in the control and against the background of increased hemodynamic load. In cardiomyocytes, glycolysis and citric acid cycle were slowed down, oxidation of free fatty acids and their metabolic products was inhibited as well as shuttle mechanisms and biosynthetic reactions. Inhibition of energy-producing processes is the cause of the lack of the contractile function energy supply and can worsen the course of cardiovascular diseases and increase the risk of their complications in conditions, accompanied by increased blood cytokine level.</description><subject>Aortic stenosis</subject><subject>Aortic valve stenosis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cardiomyocytes</subject><subject>Cardiovascular diseases</subject><subject>Cell Biology</subject><subject>Citric acid</subject><subject>Contractility</subject><subject>Cytokines</subject><subject>Fatty acids</subject><subject>Glucose metabolism</subject><subject>Glycolysis</subject><subject>Interleukin 1</subject><subject>Interleukin 2</subject><subject>Interleukin 6</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Metabolism</subject><subject>Myocardium</subject><subject>Oxidation</subject><subject>Pathology</subject><subject>Physiological aspects</subject><subject>Stenosis</subject><subject>Tricarboxylic acid cycle</subject><subject>Ventricle</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1ktFqFDEUhgdR7Fp9AG8kIIg3U5PMZCe5LEu1hW29sPfhbHKmOzWTrEkG3Jfwmc10q7aihBDC-f7DOT9_Vb1m9IRR2n1IjArW1bTcRrW8bp9UCya6ppacs6fVghaobqWUR9WLlG7nL12y59URV6zrpOSL6sdZ36PJJPQkb5FcQZ4iOLLa5_B18EhWYdw5_E6Cv6t_yXEyBUEC3pJLzLAJbkjjrF8FnyOYPDgkl_tgINphGslViCM4t79TTN5iJBfeRISElpzjGOzewzgYsg5gX1bPenAJX92_x9X1x7Pr1Xm9_vzpYnW6rk3b0Vyjgg0XChvZSmtVozjb9GKDvFGATIFcggLaM8uBGsWUQmYs7y3aZaeEaI6r94e2uxi-TZiyHodk0DnwGKakmVoq1YjiYkHf_oXehin6MtxMSa5EK-Qf6gYc6sH3YbZibqpPBRdMlrGbQp38gyrHYjEgeOyLd48F7x4Itggub1NwUx6CT49BdgBNDClF7PUuDiPEvWZUz1nRh6zokhU9Z0W3RfPmfrNpM6L9rfgVjgLwA5BKyd9gfLD6f7v-BPyvyKM</recordid><startdate>20171201</startdate><enddate>20171201</enddate><creator>Tverskaya, M. S.</creator><creator>Gankovskaya, L. V.</creator><creator>Sukhoparova, V. V.</creator><creator>Virganskii, A. O.</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20171201</creationdate><title>Effect of the Natural Cytokine Complex on the Structure and Metabolism of Contractile Myocardium Normally and under Increased Hemodynamic Load</title><author>Tverskaya, M. S. ; Gankovskaya, L. V. ; Sukhoparova, V. V. ; Virganskii, A. O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-e9ab259e3848dd93921bf5be239ae19a86a9a0f1d2a0c9199e1cd2fded679553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aortic stenosis</topic><topic>Aortic valve stenosis</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cardiomyocytes</topic><topic>Cardiovascular diseases</topic><topic>Cell Biology</topic><topic>Citric acid</topic><topic>Contractility</topic><topic>Cytokines</topic><topic>Fatty acids</topic><topic>Glucose metabolism</topic><topic>Glycolysis</topic><topic>Interleukin 1</topic><topic>Interleukin 2</topic><topic>Interleukin 6</topic><topic>Internal Medicine</topic><topic>Laboratory Medicine</topic><topic>Metabolism</topic><topic>Myocardium</topic><topic>Oxidation</topic><topic>Pathology</topic><topic>Physiological aspects</topic><topic>Stenosis</topic><topic>Tricarboxylic acid cycle</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tverskaya, M. S.</creatorcontrib><creatorcontrib>Gankovskaya, L. V.</creatorcontrib><creatorcontrib>Sukhoparova, V. V.</creatorcontrib><creatorcontrib>Virganskii, A. O.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Bulletin of experimental biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tverskaya, M. S.</au><au>Gankovskaya, L. V.</au><au>Sukhoparova, V. V.</au><au>Virganskii, A. O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of the Natural Cytokine Complex on the Structure and Metabolism of Contractile Myocardium Normally and under Increased Hemodynamic Load</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2017-12-01</date><risdate>2017</risdate><volume>164</volume><issue>2</issue><spage>136</spage><epage>139</epage><pages>136-139</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><abstract>Effect of natural complex of cytokines with activity of IL-1, IL-2, IL-6, TNF, MIF, GTFβ on the structure and metabolism of contractile ventricular cardiomyocytes was assessed in the control and under conditions of acute experimental aortic stenosis. Systemic administration of the complex in the control had no significant effect on myocardial morphology with low number of damaged cardiomyocytes and low degree of structural damage. Administration of the cytokine complex against the background of aortic stenosis did not exert any additional alterative effect on cardiomyocytes, structural damage of contractual nature was moderate. Systemic administration of the natural cytokine complex had a pronounced inhibitory effect on metabolic processes in the myocardium of both ventricles both in the control and against the background of increased hemodynamic load. In cardiomyocytes, glycolysis and citric acid cycle were slowed down, oxidation of free fatty acids and their metabolic products was inhibited as well as shuttle mechanisms and biosynthetic reactions. Inhibition of energy-producing processes is the cause of the lack of the contractile function energy supply and can worsen the course of cardiovascular diseases and increase the risk of their complications in conditions, accompanied by increased blood cytokine level.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>29177882</pmid><doi>10.1007/s10517-017-3942-4</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-4888 |
| ispartof | Bulletin of experimental biology and medicine, 2017-12, Vol.164 (2), p.136-139 |
| issn | 0007-4888 1573-8221 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1969935221 |
| source | SpringerLink Journals |
| subjects | Aortic stenosis Aortic valve stenosis Biomedical and Life Sciences Biomedicine Cardiomyocytes Cardiovascular diseases Cell Biology Citric acid Contractility Cytokines Fatty acids Glucose metabolism Glycolysis Interleukin 1 Interleukin 2 Interleukin 6 Internal Medicine Laboratory Medicine Metabolism Myocardium Oxidation Pathology Physiological aspects Stenosis Tricarboxylic acid cycle Ventricle |
| title | Effect of the Natural Cytokine Complex on the Structure and Metabolism of Contractile Myocardium Normally and under Increased Hemodynamic Load |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T11%3A01%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20the%20Natural%20Cytokine%20Complex%20on%20the%20Structure%20and%20Metabolism%20of%20Contractile%20Myocardium%20Normally%20and%20under%20Increased%20Hemodynamic%20Load&rft.jtitle=Bulletin%20of%20experimental%20biology%20and%20medicine&rft.au=Tverskaya,%20M.%20S.&rft.date=2017-12-01&rft.volume=164&rft.issue=2&rft.spage=136&rft.epage=139&rft.pages=136-139&rft.issn=0007-4888&rft.eissn=1573-8221&rft_id=info:doi/10.1007/s10517-017-3942-4&rft_dat=%3Cgale_proqu%3EA525184703%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1968295458&rft_id=info:pmid/29177882&rft_galeid=A525184703&rfr_iscdi=true |