High prognostic value of pre-allogeneic stem cell transplantation minimal residual disease detection by WT1 gene expression in AML transplanted in cytologic complete remission

•MRD in AML has become one of the most important factors to determine prognosis and therapeutic choices.•We analyzed the prognostic value of pre-SCT MRD, evaluated by WT1 expression.•Cases with cCR and MRD-WT1 negativity pre-SCT have lower Relapse Rate and better OS.•Pre-SCT WT1 expression is a powe...

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Veröffentlicht in:	Leukemia research 2017-12, Vol.63, p.22-27
Hauptverfasser:	Candoni, Anna, De Marchi, Federico, Zannier, Maria Elena, Lazzarotto, Davide, Filì, Carla, Dubbini, Maria Vittoria, Rabassi, Nicholas, Toffoletti, Eleonora, Lau, Bonnie W., Fanin, Renato
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Allogeneic hematopoietic stem cell transplant AML Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Female Follow-Up Studies Humans Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - pathology Leukemia, Myeloid, Acute - therapy Male Middle Aged Minimal residual disease (MRD) Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - therapy Neoplasm, Residual - genetics Neoplasm, Residual - pathology Neoplasm, Residual - therapy Prognosis Remission Induction Stem Cell Transplantation Survival Rate Transplantation, Homologous WT1 gene expression WT1 Proteins - genetics WT1 Proteins - metabolism Young Adult
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