Intrinsic Ribosome Destabilization Underlies Translation and Provides an Organism with a Strategy of Environmental Sensing

Nascent polypeptides can modulate the polypeptide elongation speed on the ribosome. Here, we show that nascent chains can even destabilize the translating Escherichia coli ribosome from within. This phenomenon, termed intrinsic ribosome destabilization (IRD), occurs in response to a special amino ac...

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Veröffentlicht in:	Molecular cell 2017-11, Vol.68 (3), p.528-539.e5
Hauptverfasser:	Chadani, Yuhei, Niwa, Tatsuya, Izumi, Takashi, Sugata, Nobuyuki, Nagao, Asuteka, Suzuki, Tsutomu, Chiba, Shinobu, Ito, Koreaki, Taguchi, Hideki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - chemistry Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism bL31 cell-free translation Escherichia coli - chemistry Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Gene Expression Regulation, Bacterial Magnesium - metabolism magnesium sensing Membrane Transport Proteins - chemistry Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism MgtA mgtL Mutation nascent chain peptidyl-tRNA peptidyl-tRNA hydrolase Protein Biosynthesis Protein Conformation Protein Stability PURE system Ribosomal Proteins - chemistry Ribosomal Proteins - genetics Ribosomal Proteins - metabolism ribosome splitting Ribosomes - chemistry Ribosomes - genetics Ribosomes - metabolism RNA, Transfer, Amino Acyl - chemistry RNA, Transfer, Amino Acyl - genetics RNA, Transfer, Amino Acyl - metabolism Structure-Activity Relationship
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