Resveratrol modulates response against acute inflammatory stimuli in aged mouse brain
With upcoming age, the capability to fight against harmful stimuli decreases and the organism becomes more susceptible to infections and diseases. Here, the objective was to demonstrate the effect of dietary resveratrol in aged mice in potentiating brain defenses against LipoPolySaccharide (LPS). Ac...
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| Veröffentlicht in: | Experimental gerontology 2018-02, Vol.102, p.3-11 |
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| creator | Palomera-Ávalos, V. Griñán-Ferré, C. Izquierdo, V. Camins, A. Sanfeliu, C. Canudas, A.M. Pallàs, M. |
| description | With upcoming age, the capability to fight against harmful stimuli decreases and the organism becomes more susceptible to infections and diseases. Here, the objective was to demonstrate the effect of dietary resveratrol in aged mice in potentiating brain defenses against LipoPolySaccharide (LPS). Acute LPS injection induced a strong proinflammatory effect in 24-months-old C57/BL6 mice hippocampi, increasing InterLeukin (Il)-6, Tumor Necrosis Factor-alpha (Tnf-α), Il-1β, and C-X-C motif chemokine (Cxcl10) gene expression levels. Resveratrol induced higher expression in those cytokines regarding to LPS. Oxidative Stress (OS) markers showed not significant changes after LPS or resveratrol, although for resveratrol treated groups a slight increment in most of the parameters studies was observed, reaching signification for NF-kB protein levels and iNOS expression. However, Endoplasmic Reticulum (ER) stress markers demonstrated significant changes in resveratrol-treated mice after LPS treatment, specifically in eIF2α, BIP, and ATF4. Moreover, as described, resveratrol is able to inhibit the mechanistic Target of Rapamycin (mTOR) pathway and this effect could be linked to (eIF2α) phosphorylation and the increase in the expression of the previously mentioned proinflammatory genes as a response to LPS treatment in aged animals. In conclusion, resveratrol treatment induced a different cellular response in aged animals when they encountered acute inflammatory stimuli.
•Acute LPS injection induced proinflammatory effect in 24-months-old C57/BL6 mice hippocampi, without oxidative stress changes•Dietary Resveratrol induced higher expression in cytokines only after in LPS-treated animals.•Resveratrol change the response to LPS on Reticulum stress proteins specifically in eIF2α, BIP, and ATF4•Resveratrol modulated cellular response in aged animals when they encountered acute inflammatory stimuli. |
| doi_str_mv | 10.1016/j.exger.2017.11.014 |
| format | Article |
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•Acute LPS injection induced proinflammatory effect in 24-months-old C57/BL6 mice hippocampi, without oxidative stress changes•Dietary Resveratrol induced higher expression in cytokines only after in LPS-treated animals.•Resveratrol change the response to LPS on Reticulum stress proteins specifically in eIF2α, BIP, and ATF4•Resveratrol modulated cellular response in aged animals when they encountered acute inflammatory stimuli.</description><identifier>ISSN: 0531-5565</identifier><identifier>EISSN: 1873-6815</identifier><identifier>DOI: 10.1016/j.exger.2017.11.014</identifier><identifier>PMID: 29174969</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Age Factors ; Aging ; Animals ; Anti-Inflammatory Agents - pharmacology ; Cytokines ; Cytokines - genetics ; Cytokines - metabolism ; Disease Models, Animal ; Endoplasmic Reticulum Stress - drug effects ; eukaryotic Initiation Factor 2 (eIF2) ; Eukaryotic Initiation Factor-2B - metabolism ; Gene Expression Regulation ; Hippocampus - drug effects ; Hippocampus - metabolism ; Inflammation ; Inflammation - chemically induced ; Inflammation - genetics ; Inflammation - metabolism ; Inflammation - prevention & control ; Inflammation Mediators - metabolism ; iNOS ; Lipopolysaccharides ; Male ; Mice, Inbred C57BL ; mTOR ; NF-kappa B - metabolism ; Nitric Oxide Synthase Type II - genetics ; Nitric Oxide Synthase Type II - metabolism ; Oxidative Stress - drug effects ; Phosphorylation ; Resveratrol - pharmacology ; Signal Transduction - drug effects ; TOR Serine-Threonine Kinases - metabolism</subject><ispartof>Experimental gerontology, 2018-02, Vol.102, p.3-11</ispartof><rights>2017 Elsevier Inc.</rights><rights>Copyright © 2017 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-d34c9382cef31d4a3e3242db4ca989122e803ed38b01582a815769fcb924c83f3</citedby><cites>FETCH-LOGICAL-c359t-d34c9382cef31d4a3e3242db4ca989122e803ed38b01582a815769fcb924c83f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.exger.2017.11.014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29174969$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Palomera-Ávalos, V.</creatorcontrib><creatorcontrib>Griñán-Ferré, C.</creatorcontrib><creatorcontrib>Izquierdo, V.</creatorcontrib><creatorcontrib>Camins, A.</creatorcontrib><creatorcontrib>Sanfeliu, C.</creatorcontrib><creatorcontrib>Canudas, A.M.</creatorcontrib><creatorcontrib>Pallàs, M.</creatorcontrib><title>Resveratrol modulates response against acute inflammatory stimuli in aged mouse brain</title><title>Experimental gerontology</title><addtitle>Exp Gerontol</addtitle><description>With upcoming age, the capability to fight against harmful stimuli decreases and the organism becomes more susceptible to infections and diseases. Here, the objective was to demonstrate the effect of dietary resveratrol in aged mice in potentiating brain defenses against LipoPolySaccharide (LPS). Acute LPS injection induced a strong proinflammatory effect in 24-months-old C57/BL6 mice hippocampi, increasing InterLeukin (Il)-6, Tumor Necrosis Factor-alpha (Tnf-α), Il-1β, and C-X-C motif chemokine (Cxcl10) gene expression levels. Resveratrol induced higher expression in those cytokines regarding to LPS. Oxidative Stress (OS) markers showed not significant changes after LPS or resveratrol, although for resveratrol treated groups a slight increment in most of the parameters studies was observed, reaching signification for NF-kB protein levels and iNOS expression. However, Endoplasmic Reticulum (ER) stress markers demonstrated significant changes in resveratrol-treated mice after LPS treatment, specifically in eIF2α, BIP, and ATF4. Moreover, as described, resveratrol is able to inhibit the mechanistic Target of Rapamycin (mTOR) pathway and this effect could be linked to (eIF2α) phosphorylation and the increase in the expression of the previously mentioned proinflammatory genes as a response to LPS treatment in aged animals. In conclusion, resveratrol treatment induced a different cellular response in aged animals when they encountered acute inflammatory stimuli.
•Acute LPS injection induced proinflammatory effect in 24-months-old C57/BL6 mice hippocampi, without oxidative stress changes•Dietary Resveratrol induced higher expression in cytokines only after in LPS-treated animals.•Resveratrol change the response to LPS on Reticulum stress proteins specifically in eIF2α, BIP, and ATF4•Resveratrol modulated cellular response in aged animals when they encountered acute inflammatory stimuli.</description><subject>Age Factors</subject><subject>Aging</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Cytokines</subject><subject>Cytokines - genetics</subject><subject>Cytokines - metabolism</subject><subject>Disease Models, Animal</subject><subject>Endoplasmic Reticulum Stress - drug effects</subject><subject>eukaryotic Initiation Factor 2 (eIF2)</subject><subject>Eukaryotic Initiation Factor-2B - metabolism</subject><subject>Gene Expression Regulation</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Inflammation</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - genetics</subject><subject>Inflammation - metabolism</subject><subject>Inflammation - prevention & control</subject><subject>Inflammation Mediators - metabolism</subject><subject>iNOS</subject><subject>Lipopolysaccharides</subject><subject>Male</subject><subject>Mice, Inbred C57BL</subject><subject>mTOR</subject><subject>NF-kappa B - metabolism</subject><subject>Nitric Oxide Synthase Type II - genetics</subject><subject>Nitric Oxide Synthase Type II - metabolism</subject><subject>Oxidative Stress - drug effects</subject><subject>Phosphorylation</subject><subject>Resveratrol - pharmacology</subject><subject>Signal Transduction - drug effects</subject><subject>TOR Serine-Threonine Kinases - metabolism</subject><issn>0531-5565</issn><issn>1873-6815</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKAzEUhoMoWqtPIMgs3cyYk8wtCxdSvIEgiF2HTHKmpMylJpli395o1aWrA-H_cs7_EXIBNAMK5fU6w48VuoxRqDKAjEJ-QGZQVzwtaygOyYwWHNKiKIsTcur9mlJaMg7H5IQJqHJRihlZvqLfolPBjV3Sj2bqVECfOPSbcfCYqJWygw-J0lPAxA5tp_pehdHtEh9sP3U2PsYUmkhPEWhcBM7IUas6j-c_c06W93dvi8f0-eXhaXH7nGpeiJAanmvBa6ax5WByxZGznJkm10rUAhjDmnI0vG4oFDVTsVVVilY3guW65i2fk6v9vxs3vk_og-yt19h1asB4jYTYUXCAqopRvo9qN3rvsJUbZ3vldhKo_PIp1_Lbp_zyKQFk9Bmpy58FU9Oj-WN-BcbAzT6AsebWRtxri4NGYx3qIM1o_13wCap7iJk</recordid><startdate>201802</startdate><enddate>201802</enddate><creator>Palomera-Ávalos, V.</creator><creator>Griñán-Ferré, C.</creator><creator>Izquierdo, V.</creator><creator>Camins, A.</creator><creator>Sanfeliu, C.</creator><creator>Canudas, A.M.</creator><creator>Pallàs, M.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201802</creationdate><title>Resveratrol modulates response against acute inflammatory stimuli in aged mouse brain</title><author>Palomera-Ávalos, V. ; Griñán-Ferré, C. ; Izquierdo, V. ; Camins, A. ; Sanfeliu, C. ; Canudas, A.M. ; Pallàs, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-d34c9382cef31d4a3e3242db4ca989122e803ed38b01582a815769fcb924c83f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Age Factors</topic><topic>Aging</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Cytokines</topic><topic>Cytokines - genetics</topic><topic>Cytokines - metabolism</topic><topic>Disease Models, Animal</topic><topic>Endoplasmic Reticulum Stress - drug effects</topic><topic>eukaryotic Initiation Factor 2 (eIF2)</topic><topic>Eukaryotic Initiation Factor-2B - metabolism</topic><topic>Gene Expression Regulation</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>Inflammation</topic><topic>Inflammation - chemically induced</topic><topic>Inflammation - genetics</topic><topic>Inflammation - metabolism</topic><topic>Inflammation - prevention & control</topic><topic>Inflammation Mediators - metabolism</topic><topic>iNOS</topic><topic>Lipopolysaccharides</topic><topic>Male</topic><topic>Mice, Inbred C57BL</topic><topic>mTOR</topic><topic>NF-kappa B - metabolism</topic><topic>Nitric Oxide Synthase Type II - genetics</topic><topic>Nitric Oxide Synthase Type II - metabolism</topic><topic>Oxidative Stress - drug effects</topic><topic>Phosphorylation</topic><topic>Resveratrol - pharmacology</topic><topic>Signal Transduction - drug effects</topic><topic>TOR Serine-Threonine Kinases - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Palomera-Ávalos, V.</creatorcontrib><creatorcontrib>Griñán-Ferré, C.</creatorcontrib><creatorcontrib>Izquierdo, V.</creatorcontrib><creatorcontrib>Camins, A.</creatorcontrib><creatorcontrib>Sanfeliu, C.</creatorcontrib><creatorcontrib>Canudas, A.M.</creatorcontrib><creatorcontrib>Pallàs, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental gerontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Palomera-Ávalos, V.</au><au>Griñán-Ferré, C.</au><au>Izquierdo, V.</au><au>Camins, A.</au><au>Sanfeliu, C.</au><au>Canudas, A.M.</au><au>Pallàs, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resveratrol modulates response against acute inflammatory stimuli in aged mouse brain</atitle><jtitle>Experimental gerontology</jtitle><addtitle>Exp Gerontol</addtitle><date>2018-02</date><risdate>2018</risdate><volume>102</volume><spage>3</spage><epage>11</epage><pages>3-11</pages><issn>0531-5565</issn><eissn>1873-6815</eissn><abstract>With upcoming age, the capability to fight against harmful stimuli decreases and the organism becomes more susceptible to infections and diseases. Here, the objective was to demonstrate the effect of dietary resveratrol in aged mice in potentiating brain defenses against LipoPolySaccharide (LPS). Acute LPS injection induced a strong proinflammatory effect in 24-months-old C57/BL6 mice hippocampi, increasing InterLeukin (Il)-6, Tumor Necrosis Factor-alpha (Tnf-α), Il-1β, and C-X-C motif chemokine (Cxcl10) gene expression levels. Resveratrol induced higher expression in those cytokines regarding to LPS. Oxidative Stress (OS) markers showed not significant changes after LPS or resveratrol, although for resveratrol treated groups a slight increment in most of the parameters studies was observed, reaching signification for NF-kB protein levels and iNOS expression. However, Endoplasmic Reticulum (ER) stress markers demonstrated significant changes in resveratrol-treated mice after LPS treatment, specifically in eIF2α, BIP, and ATF4. Moreover, as described, resveratrol is able to inhibit the mechanistic Target of Rapamycin (mTOR) pathway and this effect could be linked to (eIF2α) phosphorylation and the increase in the expression of the previously mentioned proinflammatory genes as a response to LPS treatment in aged animals. In conclusion, resveratrol treatment induced a different cellular response in aged animals when they encountered acute inflammatory stimuli.
•Acute LPS injection induced proinflammatory effect in 24-months-old C57/BL6 mice hippocampi, without oxidative stress changes•Dietary Resveratrol induced higher expression in cytokines only after in LPS-treated animals.•Resveratrol change the response to LPS on Reticulum stress proteins specifically in eIF2α, BIP, and ATF4•Resveratrol modulated cellular response in aged animals when they encountered acute inflammatory stimuli.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>29174969</pmid><doi>10.1016/j.exger.2017.11.014</doi><tpages>9</tpages></addata></record> |
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| subjects | Age Factors Aging Animals Anti-Inflammatory Agents - pharmacology Cytokines Cytokines - genetics Cytokines - metabolism Disease Models, Animal Endoplasmic Reticulum Stress - drug effects eukaryotic Initiation Factor 2 (eIF2) Eukaryotic Initiation Factor-2B - metabolism Gene Expression Regulation Hippocampus - drug effects Hippocampus - metabolism Inflammation Inflammation - chemically induced Inflammation - genetics Inflammation - metabolism Inflammation - prevention & control Inflammation Mediators - metabolism iNOS Lipopolysaccharides Male Mice, Inbred C57BL mTOR NF-kappa B - metabolism Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Oxidative Stress - drug effects Phosphorylation Resveratrol - pharmacology Signal Transduction - drug effects TOR Serine-Threonine Kinases - metabolism |
| title | Resveratrol modulates response against acute inflammatory stimuli in aged mouse brain |
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