Pathobiological expression of the brain-derived neurotrophic factor (BDNF) in cerebellar cortex of sudden fetal and infant death victims

•BDNF is involved in development of the cerebellar cortex.•BDNF-immunoexpression was evaluated in 45 cases of sudden perinatal death.•BDNF immunonegativity was mainly highlighted prevalently in posterior cerebellar cortex of many SIUDS an SIDS.•These results were related to maternal smoking.•A patho...

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Veröffentlicht in:	International journal of developmental neuroscience 2018-05, Vol.66 (1), p.9-17
Hauptverfasser:	Lavezzi, Anna M., Ferrero, Stefano, Lattuada, Debora, Piscioli, Francesco, Alfonsi, Graziella, Matturri, Luigi
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain-Derived Neurotrophic Factor - metabolism Brain-derived neutrophic factor (BDNF) Case-Control Studies Central nerve system Cerebellar cortex Cerebellar Cortex - metabolism Cerebellar Cortex - pathology Female Fetal Death Fetus Gestational Age Glial Fibrillary Acidic Protein - metabolism Granule layers Humans Infant Infant Death Infant, Newborn Male Membrane Glycoproteins - metabolism Neuroglia - metabolism Neuroglia - pathology Neurons - metabolism Neurons - pathology Neuropathology Pregnancy Prenatal Exposure Delayed Effects - pathology Receptor, trkB - metabolism SIDS SIUDS Smoking - adverse effects Stillbirth
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