Design, synthesis and molecular modeling studies of new series of antitumor 1,2,4-triazines with potential c-Met kinase inhibitory activity

[Display omitted] •Twenty-one new 1,2,4-triazines were designed based on NCI 748494/1.•The derivatives displayed promising antitumor activities.•Double-drug design led to identifying 3d with IC50 = 2.71 µM against c-Met kinase.•3d showed binding mode with the essential amino acids in c-Met kinase do...

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