Workshop report: Nucleic acid delivery devices for HIV vaccines: Workshop proceedings, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA, May 21, 2015
On May 21st, 2015, the U.S. National Institute of Allergy and Infectious Diseases (NIAID) convened a workshop on delivery devices for nucleic acid (NA) as vaccines in order to review the landscape of past and future technologies for administering NA (e.g., DNA, RNA, etc.) as antigen into target tiss...
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| Veröffentlicht in: | Vaccine 2018-01, Vol.36 (4), p.427-437 |
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| creator | Weniger, Bruce G. Anglin, Ian E. Tong, Tina Pensiero, Michael Pullen, Jeffrey K. |
| description | On May 21st, 2015, the U.S. National Institute of Allergy and Infectious Diseases (NIAID) convened a workshop on delivery devices for nucleic acid (NA) as vaccines in order to review the landscape of past and future technologies for administering NA (e.g., DNA, RNA, etc.) as antigen into target tissues of animal models and humans. Its focus was on current and future applications for preventing and treating human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS) disease, among other infectious-disease priorities. Meeting participants presented the results and experience of representative clinical trials of NA vaccines using a variety of alternative delivery devices, as well as a broader group of methods studied in animal models and at bench top, to improve upon the performance and/or avoid the drawbacks of conventional needle-syringe (N–S) delivery. The subjects described and discussed included (1) delivery targeted into oral, cutaneous/intradermal, nasal, upper and lower respiratory, and intramuscular tissues; (2) devices and techniques for jet injection, solid, hollow, and dissolving microneedles, patches for topical passive diffusion or iontophoresis, electroporation, thermal microporation, nasal sprayers, aerosol upper-respiratory and pulmonary inhalation, stratum-corneum ablation by ultrasound, chemicals, and mechanical abrasion, and kinetic/ballistic delivery; (3) antigens, adjuvants, and carriers such as DNA, messenger RNA, synthesized plasmids, chemokines, wet and dry aerosols, and pollen-grain and microparticle vectors; and (4) the clinical experience and humoral, cellular, and cytokine immune responses observed for many of these target tissues, technologies, constructs, and carriers. This report summarizes the presentations and discussions from the workshop (https://web.archive.org/web/20160228112310/https://www.blsmeetings.net/NucleicAcidDeliveryDevices/), which was webcast live in its entirety and archived online (http://videocast.nih.gov/summary.asp?live=16059). |
| doi_str_mv | 10.1016/j.vaccine.2017.10.071 |
| format | Article |
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Its focus was on current and future applications for preventing and treating human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS) disease, among other infectious-disease priorities. Meeting participants presented the results and experience of representative clinical trials of NA vaccines using a variety of alternative delivery devices, as well as a broader group of methods studied in animal models and at bench top, to improve upon the performance and/or avoid the drawbacks of conventional needle-syringe (N–S) delivery. The subjects described and discussed included (1) delivery targeted into oral, cutaneous/intradermal, nasal, upper and lower respiratory, and intramuscular tissues; (2) devices and techniques for jet injection, solid, hollow, and dissolving microneedles, patches for topical passive diffusion or iontophoresis, electroporation, thermal microporation, nasal sprayers, aerosol upper-respiratory and pulmonary inhalation, stratum-corneum ablation by ultrasound, chemicals, and mechanical abrasion, and kinetic/ballistic delivery; (3) antigens, adjuvants, and carriers such as DNA, messenger RNA, synthesized plasmids, chemokines, wet and dry aerosols, and pollen-grain and microparticle vectors; and (4) the clinical experience and humoral, cellular, and cytokine immune responses observed for many of these target tissues, technologies, constructs, and carriers. This report summarizes the presentations and discussions from the workshop (https://web.archive.org/web/20160228112310/https://www.blsmeetings.net/NucleicAcidDeliveryDevices/), which was webcast live in its entirety and archived online (http://videocast.nih.gov/summary.asp?live=16059).</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2017.10.071</identifier><identifier>PMID: 29174315</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Abrasion ; Acquired immune deficiency syndrome ; Adjuvants ; Aerosols ; AIDS ; Allergies ; Animal models ; Antigens ; Chemokines ; Clinical trials ; Cutaneous ; Delivery ; Deoxyribonucleic acid ; Devices ; DNA ; Drug delivery systems ; Electroporation ; HIV ; Human immunodeficiency virus ; Immune response (humoral) ; Infectious diseases ; Influenza ; Inhalation ; Intradermal ; Intranasal ; Iontophoresis ; Jet Injection ; Laser ; Medical research ; Microneedles ; mRNA ; Needles ; Nucleic acids ; Patch ; Plasmids ; Pollen ; Proteins ; Respiration ; Respiratory ; Ribonucleic acid ; RNA ; Skin ; Sprayers ; Technology ; Ultrasound ; Vaccination ; Vaccines ; Viruses</subject><ispartof>Vaccine, 2018-01, Vol.36 (4), p.427-437</ispartof><rights>2018</rights><rights>Copyright © 2018.</rights><rights>Copyright Elsevier Limited Jan 25, 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-d012ff38632d573a89d9d22b0654efd284832c4b60641b70ba78732bbafee65f3</citedby><cites>FETCH-LOGICAL-c393t-d012ff38632d573a89d9d22b0654efd284832c4b60641b70ba78732bbafee65f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0264410X17314792$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29174315$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weniger, Bruce G.</creatorcontrib><creatorcontrib>Anglin, Ian E.</creatorcontrib><creatorcontrib>Tong, Tina</creatorcontrib><creatorcontrib>Pensiero, Michael</creatorcontrib><creatorcontrib>Pullen, Jeffrey K.</creatorcontrib><creatorcontrib>Nucleic Acid Delivery Devices for HIV Vaccines Workshop Group</creatorcontrib><title>Workshop report: Nucleic acid delivery devices for HIV vaccines: Workshop proceedings, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA, May 21, 2015</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>On May 21st, 2015, the U.S. National Institute of Allergy and Infectious Diseases (NIAID) convened a workshop on delivery devices for nucleic acid (NA) as vaccines in order to review the landscape of past and future technologies for administering NA (e.g., DNA, RNA, etc.) as antigen into target tissues of animal models and humans. Its focus was on current and future applications for preventing and treating human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS) disease, among other infectious-disease priorities. Meeting participants presented the results and experience of representative clinical trials of NA vaccines using a variety of alternative delivery devices, as well as a broader group of methods studied in animal models and at bench top, to improve upon the performance and/or avoid the drawbacks of conventional needle-syringe (N–S) delivery. The subjects described and discussed included (1) delivery targeted into oral, cutaneous/intradermal, nasal, upper and lower respiratory, and intramuscular tissues; (2) devices and techniques for jet injection, solid, hollow, and dissolving microneedles, patches for topical passive diffusion or iontophoresis, electroporation, thermal microporation, nasal sprayers, aerosol upper-respiratory and pulmonary inhalation, stratum-corneum ablation by ultrasound, chemicals, and mechanical abrasion, and kinetic/ballistic delivery; (3) antigens, adjuvants, and carriers such as DNA, messenger RNA, synthesized plasmids, chemokines, wet and dry aerosols, and pollen-grain and microparticle vectors; and (4) the clinical experience and humoral, cellular, and cytokine immune responses observed for many of these target tissues, technologies, constructs, and carriers. 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Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Workshop report: Nucleic acid delivery devices for HIV vaccines: Workshop proceedings, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA, May 21, 2015</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2018-01-25</date><risdate>2018</risdate><volume>36</volume><issue>4</issue><spage>427</spage><epage>437</epage><pages>427-437</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><abstract>On May 21st, 2015, the U.S. National Institute of Allergy and Infectious Diseases (NIAID) convened a workshop on delivery devices for nucleic acid (NA) as vaccines in order to review the landscape of past and future technologies for administering NA (e.g., DNA, RNA, etc.) as antigen into target tissues of animal models and humans. Its focus was on current and future applications for preventing and treating human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS) disease, among other infectious-disease priorities. Meeting participants presented the results and experience of representative clinical trials of NA vaccines using a variety of alternative delivery devices, as well as a broader group of methods studied in animal models and at bench top, to improve upon the performance and/or avoid the drawbacks of conventional needle-syringe (N–S) delivery. The subjects described and discussed included (1) delivery targeted into oral, cutaneous/intradermal, nasal, upper and lower respiratory, and intramuscular tissues; (2) devices and techniques for jet injection, solid, hollow, and dissolving microneedles, patches for topical passive diffusion or iontophoresis, electroporation, thermal microporation, nasal sprayers, aerosol upper-respiratory and pulmonary inhalation, stratum-corneum ablation by ultrasound, chemicals, and mechanical abrasion, and kinetic/ballistic delivery; (3) antigens, adjuvants, and carriers such as DNA, messenger RNA, synthesized plasmids, chemokines, wet and dry aerosols, and pollen-grain and microparticle vectors; and (4) the clinical experience and humoral, cellular, and cytokine immune responses observed for many of these target tissues, technologies, constructs, and carriers. This report summarizes the presentations and discussions from the workshop (https://web.archive.org/web/20160228112310/https://www.blsmeetings.net/NucleicAcidDeliveryDevices/), which was webcast live in its entirety and archived online (http://videocast.nih.gov/summary.asp?live=16059).</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>29174315</pmid><doi>10.1016/j.vaccine.2017.10.071</doi><tpages>11</tpages></addata></record> |
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| ispartof | Vaccine, 2018-01, Vol.36 (4), p.427-437 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals Complete |
| subjects | Abrasion Acquired immune deficiency syndrome Adjuvants Aerosols AIDS Allergies Animal models Antigens Chemokines Clinical trials Cutaneous Delivery Deoxyribonucleic acid Devices DNA Drug delivery systems Electroporation HIV Human immunodeficiency virus Immune response (humoral) Infectious diseases Influenza Inhalation Intradermal Intranasal Iontophoresis Jet Injection Laser Medical research Microneedles mRNA Needles Nucleic acids Patch Plasmids Pollen Proteins Respiration Respiratory Ribonucleic acid RNA Skin Sprayers Technology Ultrasound Vaccination Vaccines Viruses |
| title | Workshop report: Nucleic acid delivery devices for HIV vaccines: Workshop proceedings, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA, May 21, 2015 |
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