Neurotoxicity of carbon monoxide targets caudate-mediated dopaminergic system
•The implications of 99mTcTRODAT-1 for carbon monoxide intoxication parkinsonism is proposed.•The neurobehavioral deficits and parkinsonian symptoms were highly related.•Presynaptic caudate dopaminergic deficits mediate the clinical symptoms. The clinical features of parkinsonism in carbon monoxide...
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| Veröffentlicht in: | Neurotoxicology (Park Forest South) 2018-03, Vol.65, p.272-279 |
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| creator | Sun, Tzu-Kuan Chen, Yen-Yu Huang, Shu-Hua Hsu, Shih-Wei Lee, Chen-Chang Chang, Wen-Neng Huang, Chi-Wei Lui, Chun-Chung Lien, Chia-Yi Cheng, Ju-Ling Chang, Chiung-Chih |
| description | •The implications of 99mTcTRODAT-1 for carbon monoxide intoxication parkinsonism is proposed.•The neurobehavioral deficits and parkinsonian symptoms were highly related.•Presynaptic caudate dopaminergic deficits mediate the clinical symptoms.
The clinical features of parkinsonism in carbon monoxide (CO) intoxication have been associated with striatal-related neuronal networks. As parkinsonian and neuropsychiatric features are both related to presynaptic dopaminergic integrity, the aim of this study was to explore the clinical significance of 99mTcTRODAT-1 in grading neurobehavioral scores and parkinsonian severity in CO intoxication.
We enrolled 64 patients with CO intoxication, including 29 with parkinsonism (parkinsonism[+] group) and 35 without (parkinsonism[−] group). All of the patients received 99mTcTRODAT-1 neuroimaging evaluations, comprehensive neurobehavioral tests and assessments of the severity of parkinsonism using Unified Parkinson's Disease Rating Scale (UPDRS)-part III motor score. Univariate and multivariate regression analyses were used to test the predictive factors and scores for a diagnosis of parkinsonism and its severity.
The parkinsonism(+) group had significantly lower cognitive scores and higher neuropsychiatric total scores compared with the parkinsonism(−) group, both of which were independently related to the severity of parkinsonism. 99mTcTRODAT-1 regional caudate signals were correlated with tremors at rest, action or postural tremors of the hands, bradykinesia and hypokinesia, and visuospatial, verbal fluency, abstract thinking and digit backwards scores. Scores of the neurobehavioral tests and UPDRS items were highly correlated (p |
| doi_str_mv | 10.1016/j.neuro.2017.11.007 |
| format | Article |
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The clinical features of parkinsonism in carbon monoxide (CO) intoxication have been associated with striatal-related neuronal networks. As parkinsonian and neuropsychiatric features are both related to presynaptic dopaminergic integrity, the aim of this study was to explore the clinical significance of 99mTcTRODAT-1 in grading neurobehavioral scores and parkinsonian severity in CO intoxication.
We enrolled 64 patients with CO intoxication, including 29 with parkinsonism (parkinsonism[+] group) and 35 without (parkinsonism[−] group). All of the patients received 99mTcTRODAT-1 neuroimaging evaluations, comprehensive neurobehavioral tests and assessments of the severity of parkinsonism using Unified Parkinson's Disease Rating Scale (UPDRS)-part III motor score. Univariate and multivariate regression analyses were used to test the predictive factors and scores for a diagnosis of parkinsonism and its severity.
The parkinsonism(+) group had significantly lower cognitive scores and higher neuropsychiatric total scores compared with the parkinsonism(−) group, both of which were independently related to the severity of parkinsonism. 99mTcTRODAT-1 regional caudate signals were correlated with tremors at rest, action or postural tremors of the hands, bradykinesia and hypokinesia, and visuospatial, verbal fluency, abstract thinking and digit backwards scores. Scores of the neurobehavioral tests and UPDRS items were highly correlated (p<0.01).
Our results validated the initial hypothesis in that neurobehavioral deficits and parkinsonian symptoms were highly related. This association was independent of demographic factors and initial carboxyhemoglobin level. Within the presynaptic dopaminergic circuit, the clinical role of the caudate in mediating the clinical symptoms in CO intoxication may outweigh the putamen.</description><identifier>ISSN: 0161-813X</identifier><identifier>EISSN: 1872-9711</identifier><identifier>DOI: 10.1016/j.neuro.2017.11.007</identifier><identifier>PMID: 29173994</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Basal ganglia ; Brain diseases ; Carbon monoxide ; Carbon monoxide intoxication ; Carboxyhemoglobin ; Caudate ; Central nervous system diseases ; Cognitive ability ; Demographics ; Dopamine receptors ; Evaluation ; Hypokinesia ; Intoxication ; Medical imaging ; Movement disorders ; Neostriatum ; Neural networks ; Neurodegenerative diseases ; Neuroimaging ; Neurology ; Neurons ; Neurotoxicity ; Parkinson's disease ; Parkinsonian symptoms ; Patients ; Posture ; Pre-synaptic dopamine deficit ; Putamen ; Regression analysis ; Suicides & suicide attempts ; Tremors</subject><ispartof>Neurotoxicology (Park Forest South), 2018-03, Vol.65, p.272-279</ispartof><rights>2017</rights><rights>Copyright © 2017. Published by Elsevier B.V.</rights><rights>Copyright Elsevier BV Mar 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-565f2e40e6222b819baa203c08b5d16d03699f4e8732b7aa80ed14456ec15a523</citedby><cites>FETCH-LOGICAL-c453t-565f2e40e6222b819baa203c08b5d16d03699f4e8732b7aa80ed14456ec15a523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neuro.2017.11.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29173994$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Tzu-Kuan</creatorcontrib><creatorcontrib>Chen, Yen-Yu</creatorcontrib><creatorcontrib>Huang, Shu-Hua</creatorcontrib><creatorcontrib>Hsu, Shih-Wei</creatorcontrib><creatorcontrib>Lee, Chen-Chang</creatorcontrib><creatorcontrib>Chang, Wen-Neng</creatorcontrib><creatorcontrib>Huang, Chi-Wei</creatorcontrib><creatorcontrib>Lui, Chun-Chung</creatorcontrib><creatorcontrib>Lien, Chia-Yi</creatorcontrib><creatorcontrib>Cheng, Ju-Ling</creatorcontrib><creatorcontrib>Chang, Chiung-Chih</creatorcontrib><title>Neurotoxicity of carbon monoxide targets caudate-mediated dopaminergic system</title><title>Neurotoxicology (Park Forest South)</title><addtitle>Neurotoxicology</addtitle><description>•The implications of 99mTcTRODAT-1 for carbon monoxide intoxication parkinsonism is proposed.•The neurobehavioral deficits and parkinsonian symptoms were highly related.•Presynaptic caudate dopaminergic deficits mediate the clinical symptoms.
The clinical features of parkinsonism in carbon monoxide (CO) intoxication have been associated with striatal-related neuronal networks. As parkinsonian and neuropsychiatric features are both related to presynaptic dopaminergic integrity, the aim of this study was to explore the clinical significance of 99mTcTRODAT-1 in grading neurobehavioral scores and parkinsonian severity in CO intoxication.
We enrolled 64 patients with CO intoxication, including 29 with parkinsonism (parkinsonism[+] group) and 35 without (parkinsonism[−] group). All of the patients received 99mTcTRODAT-1 neuroimaging evaluations, comprehensive neurobehavioral tests and assessments of the severity of parkinsonism using Unified Parkinson's Disease Rating Scale (UPDRS)-part III motor score. Univariate and multivariate regression analyses were used to test the predictive factors and scores for a diagnosis of parkinsonism and its severity.
The parkinsonism(+) group had significantly lower cognitive scores and higher neuropsychiatric total scores compared with the parkinsonism(−) group, both of which were independently related to the severity of parkinsonism. 99mTcTRODAT-1 regional caudate signals were correlated with tremors at rest, action or postural tremors of the hands, bradykinesia and hypokinesia, and visuospatial, verbal fluency, abstract thinking and digit backwards scores. Scores of the neurobehavioral tests and UPDRS items were highly correlated (p<0.01).
Our results validated the initial hypothesis in that neurobehavioral deficits and parkinsonian symptoms were highly related. This association was independent of demographic factors and initial carboxyhemoglobin level. Within the presynaptic dopaminergic circuit, the clinical role of the caudate in mediating the clinical symptoms in CO intoxication may outweigh the putamen.</description><subject>Basal ganglia</subject><subject>Brain diseases</subject><subject>Carbon monoxide</subject><subject>Carbon monoxide intoxication</subject><subject>Carboxyhemoglobin</subject><subject>Caudate</subject><subject>Central nervous system diseases</subject><subject>Cognitive ability</subject><subject>Demographics</subject><subject>Dopamine receptors</subject><subject>Evaluation</subject><subject>Hypokinesia</subject><subject>Intoxication</subject><subject>Medical imaging</subject><subject>Movement disorders</subject><subject>Neostriatum</subject><subject>Neural networks</subject><subject>Neurodegenerative diseases</subject><subject>Neuroimaging</subject><subject>Neurology</subject><subject>Neurons</subject><subject>Neurotoxicity</subject><subject>Parkinson's disease</subject><subject>Parkinsonian symptoms</subject><subject>Patients</subject><subject>Posture</subject><subject>Pre-synaptic dopamine deficit</subject><subject>Putamen</subject><subject>Regression analysis</subject><subject>Suicides & suicide attempts</subject><subject>Tremors</subject><issn>0161-813X</issn><issn>1872-9711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kE1v1DAQhi0EotvCL0BCkbhwSfD4Mz5wQBVQpNJeQOJmOc6k8moTL7aDuv8eL1s4cOhppNHzvjN6CHkFtAMK6t22W3BNsWMUdAfQUaqfkA30mrVGAzwlm0pB2wP_cUbOc95SClIr85ycMQOaGyM25OvNsaPE--BDOTRxarxLQ1yaOS51OWJTXLrDkut-HV3BdsYx1Dk2Y9y7OSyY7oJv8iEXnF-QZ5PbZXz5MC_I908fv11etde3n79cfrhuvZC8tFLJiaGgqBhjQw9mcI5R7mk_yBHUSLkyZhLYa84G7VxPcQQhpEIP0knGL8jbU-8-xZ8r5mLnkD3udm7BuGYLphYwzYWu6Jv_0G1c01K_s4xKJZQAKSvFT5RPMeeEk92nMLt0sEDt0bbd2j-27dG2BbDVdk29fuheh6rlX-av3gq8PwFYZfwKmGz2ARdfFSb0xY4xPHrgN23TkW0</recordid><startdate>201803</startdate><enddate>201803</enddate><creator>Sun, Tzu-Kuan</creator><creator>Chen, Yen-Yu</creator><creator>Huang, Shu-Hua</creator><creator>Hsu, Shih-Wei</creator><creator>Lee, Chen-Chang</creator><creator>Chang, Wen-Neng</creator><creator>Huang, Chi-Wei</creator><creator>Lui, Chun-Chung</creator><creator>Lien, Chia-Yi</creator><creator>Cheng, Ju-Ling</creator><creator>Chang, Chiung-Chih</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>201803</creationdate><title>Neurotoxicity of carbon monoxide targets caudate-mediated dopaminergic system</title><author>Sun, Tzu-Kuan ; Chen, Yen-Yu ; Huang, Shu-Hua ; Hsu, Shih-Wei ; Lee, Chen-Chang ; Chang, Wen-Neng ; Huang, Chi-Wei ; Lui, Chun-Chung ; Lien, Chia-Yi ; Cheng, Ju-Ling ; Chang, Chiung-Chih</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-565f2e40e6222b819baa203c08b5d16d03699f4e8732b7aa80ed14456ec15a523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Basal ganglia</topic><topic>Brain diseases</topic><topic>Carbon monoxide</topic><topic>Carbon monoxide intoxication</topic><topic>Carboxyhemoglobin</topic><topic>Caudate</topic><topic>Central nervous system diseases</topic><topic>Cognitive ability</topic><topic>Demographics</topic><topic>Dopamine receptors</topic><topic>Evaluation</topic><topic>Hypokinesia</topic><topic>Intoxication</topic><topic>Medical imaging</topic><topic>Movement disorders</topic><topic>Neostriatum</topic><topic>Neural networks</topic><topic>Neurodegenerative diseases</topic><topic>Neuroimaging</topic><topic>Neurology</topic><topic>Neurons</topic><topic>Neurotoxicity</topic><topic>Parkinson's disease</topic><topic>Parkinsonian symptoms</topic><topic>Patients</topic><topic>Posture</topic><topic>Pre-synaptic dopamine deficit</topic><topic>Putamen</topic><topic>Regression analysis</topic><topic>Suicides & suicide attempts</topic><topic>Tremors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Tzu-Kuan</creatorcontrib><creatorcontrib>Chen, Yen-Yu</creatorcontrib><creatorcontrib>Huang, Shu-Hua</creatorcontrib><creatorcontrib>Hsu, Shih-Wei</creatorcontrib><creatorcontrib>Lee, Chen-Chang</creatorcontrib><creatorcontrib>Chang, Wen-Neng</creatorcontrib><creatorcontrib>Huang, Chi-Wei</creatorcontrib><creatorcontrib>Lui, Chun-Chung</creatorcontrib><creatorcontrib>Lien, Chia-Yi</creatorcontrib><creatorcontrib>Cheng, Ju-Ling</creatorcontrib><creatorcontrib>Chang, Chiung-Chih</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Neurotoxicology (Park Forest South)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Tzu-Kuan</au><au>Chen, Yen-Yu</au><au>Huang, Shu-Hua</au><au>Hsu, Shih-Wei</au><au>Lee, Chen-Chang</au><au>Chang, Wen-Neng</au><au>Huang, Chi-Wei</au><au>Lui, Chun-Chung</au><au>Lien, Chia-Yi</au><au>Cheng, Ju-Ling</au><au>Chang, Chiung-Chih</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurotoxicity of carbon monoxide targets caudate-mediated dopaminergic system</atitle><jtitle>Neurotoxicology (Park Forest South)</jtitle><addtitle>Neurotoxicology</addtitle><date>2018-03</date><risdate>2018</risdate><volume>65</volume><spage>272</spage><epage>279</epage><pages>272-279</pages><issn>0161-813X</issn><eissn>1872-9711</eissn><abstract>•The implications of 99mTcTRODAT-1 for carbon monoxide intoxication parkinsonism is proposed.•The neurobehavioral deficits and parkinsonian symptoms were highly related.•Presynaptic caudate dopaminergic deficits mediate the clinical symptoms.
The clinical features of parkinsonism in carbon monoxide (CO) intoxication have been associated with striatal-related neuronal networks. As parkinsonian and neuropsychiatric features are both related to presynaptic dopaminergic integrity, the aim of this study was to explore the clinical significance of 99mTcTRODAT-1 in grading neurobehavioral scores and parkinsonian severity in CO intoxication.
We enrolled 64 patients with CO intoxication, including 29 with parkinsonism (parkinsonism[+] group) and 35 without (parkinsonism[−] group). All of the patients received 99mTcTRODAT-1 neuroimaging evaluations, comprehensive neurobehavioral tests and assessments of the severity of parkinsonism using Unified Parkinson's Disease Rating Scale (UPDRS)-part III motor score. Univariate and multivariate regression analyses were used to test the predictive factors and scores for a diagnosis of parkinsonism and its severity.
The parkinsonism(+) group had significantly lower cognitive scores and higher neuropsychiatric total scores compared with the parkinsonism(−) group, both of which were independently related to the severity of parkinsonism. 99mTcTRODAT-1 regional caudate signals were correlated with tremors at rest, action or postural tremors of the hands, bradykinesia and hypokinesia, and visuospatial, verbal fluency, abstract thinking and digit backwards scores. Scores of the neurobehavioral tests and UPDRS items were highly correlated (p<0.01).
Our results validated the initial hypothesis in that neurobehavioral deficits and parkinsonian symptoms were highly related. This association was independent of demographic factors and initial carboxyhemoglobin level. Within the presynaptic dopaminergic circuit, the clinical role of the caudate in mediating the clinical symptoms in CO intoxication may outweigh the putamen.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>29173994</pmid><doi>10.1016/j.neuro.2017.11.007</doi><tpages>8</tpages></addata></record> |
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| subjects | Basal ganglia Brain diseases Carbon monoxide Carbon monoxide intoxication Carboxyhemoglobin Caudate Central nervous system diseases Cognitive ability Demographics Dopamine receptors Evaluation Hypokinesia Intoxication Medical imaging Movement disorders Neostriatum Neural networks Neurodegenerative diseases Neuroimaging Neurology Neurons Neurotoxicity Parkinson's disease Parkinsonian symptoms Patients Posture Pre-synaptic dopamine deficit Putamen Regression analysis Suicides & suicide attempts Tremors |
| title | Neurotoxicity of carbon monoxide targets caudate-mediated dopaminergic system |
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