Interleukin-6 is a candidate molecule that transmits inflammatory information to the CNS
Abstract Peripheral inflammation induces reactions within the CNS such as central sensitization, which is involved in the mechanism of inflammatory hyperalgesia. However, the precise mechanism of inflammatory signal transmission from the peripheral inflammatory site to the CNS is not clear. We studi...
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| Veröffentlicht in: | Neuroscience 2007-03, Vol.145 (2), p.530-538 |
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| creator | Oka, Y Ibuki, T Matsumura, K Namba, M Yamazaki, Y Poole, S Tanaka, Y Kobayashi, S |
| description | Abstract Peripheral inflammation induces reactions within the CNS such as central sensitization, which is involved in the mechanism of inflammatory hyperalgesia. However, the precise mechanism of inflammatory signal transmission from the peripheral inflammatory site to the CNS is not clear. We studied the role of circulating interleukin (IL)-6 as a messenger of inflammatory information from the periphery to the CNS. In the rat model of inflammatory hyperalgesia induced by carrageenan, levels of IL-6 but not IL-1β or tumor necrosis factor alpha (TNFα) were significantly elevated in the circulating blood 3 h after an injection of carrageenan. In addition, injecting carrageenan into the hind paw evoked thermal hyperalgesia and the release of prostaglandin E2 (PGE2 ) from isolated blood vessels of the CNS ex vivo, as well as the induction of cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase (mPGES)-1 and nuclear translocation of signal transducer and activator of transcription 3 (STAT3) in vascular endothelial cells of the CNS. A prior i.p. injection of IL-6 antiserum (IL-6AS) abolished or attenuated these responses. The present results suggested that circulating IL-6 could act as a messenger of inflammatory information from peripheral inflammatory sites to the CNS and as the afferent circulating signal to the CNS to produce prostaglandins in the vascular endothelial cells of the CNS through a COX-2 dependent pathway. |
| doi_str_mv | 10.1016/j.neuroscience.2006.10.055 |
| format | Article |
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However, the precise mechanism of inflammatory signal transmission from the peripheral inflammatory site to the CNS is not clear. We studied the role of circulating interleukin (IL)-6 as a messenger of inflammatory information from the periphery to the CNS. In the rat model of inflammatory hyperalgesia induced by carrageenan, levels of IL-6 but not IL-1β or tumor necrosis factor alpha (TNFα) were significantly elevated in the circulating blood 3 h after an injection of carrageenan. In addition, injecting carrageenan into the hind paw evoked thermal hyperalgesia and the release of prostaglandin E2 (PGE2 ) from isolated blood vessels of the CNS ex vivo, as well as the induction of cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase (mPGES)-1 and nuclear translocation of signal transducer and activator of transcription 3 (STAT3) in vascular endothelial cells of the CNS. A prior i.p. injection of IL-6 antiserum (IL-6AS) abolished or attenuated these responses. The present results suggested that circulating IL-6 could act as a messenger of inflammatory information from peripheral inflammatory sites to the CNS and as the afferent circulating signal to the CNS to produce prostaglandins in the vascular endothelial cells of the CNS through a COX-2 dependent pathway.</description><identifier>ISSN: 0306-4522</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/j.neuroscience.2006.10.055</identifier><identifier>PMID: 17303338</identifier><identifier>CODEN: NRSCDN</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Afferent Pathways - immunology ; Animals ; Antibodies - pharmacology ; Biological and medical sciences ; Central Nervous System - immunology ; Cyclooxygenase 2 - blood ; Cyclooxygenase 2 - secretion ; cyclooxygenase-2 ; Dinoprostone - blood ; Dinoprostone - secretion ; Endothelial Cells - immunology ; Endothelial Cells - metabolism ; Endothelial Cells - secretion ; Foot - innervation ; Foot - physiopathology ; Fundamental and applied biological sciences. Psychology ; hyperalgesia ; Hyperalgesia - chemically induced ; Hyperalgesia - immunology ; Hyperalgesia - physiopathology ; inflammation ; Inflammation - immunology ; Inflammation - physiopathology ; Inflammation Mediators - adverse effects ; Interleukin-6 - antagonists & inhibitors ; Interleukin-6 - blood ; Interleukin-6 - immunology ; Male ; Medical sciences ; Nervous system (semeiology, syndromes) ; Nervous system as a whole ; Neurology ; Peripheral Nerves - immunology ; prostaglandin ; Prostaglandin-E Synthases ; Prostaglandin-Endoperoxide Synthases - blood ; Prostaglandin-Endoperoxide Synthases - secretion ; Rats ; Rats, Sprague-Dawley ; Sensory Receptor Cells - immunology ; Sensory Receptor Cells - physiopathology ; Signal Transduction - immunology ; STAT3 Transcription Factor - blood ; STAT3 Transcription Factor - secretion ; Up-Regulation - drug effects ; Up-Regulation - physiology ; vascular endothelial cells ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience, 2007-03, Vol.145 (2), p.530-538</ispartof><rights>IBRO</rights><rights>2006 IBRO</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-37379bd20cc460fb49f1068b6182727efcd4c3d25944c4e2acccdd9cdf06ff123</citedby><cites>FETCH-LOGICAL-c494t-37379bd20cc460fb49f1068b6182727efcd4c3d25944c4e2acccdd9cdf06ff123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0306452206014709$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18636314$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17303338$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oka, Y</creatorcontrib><creatorcontrib>Ibuki, T</creatorcontrib><creatorcontrib>Matsumura, K</creatorcontrib><creatorcontrib>Namba, M</creatorcontrib><creatorcontrib>Yamazaki, Y</creatorcontrib><creatorcontrib>Poole, S</creatorcontrib><creatorcontrib>Tanaka, Y</creatorcontrib><creatorcontrib>Kobayashi, S</creatorcontrib><title>Interleukin-6 is a candidate molecule that transmits inflammatory information to the CNS</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>Abstract Peripheral inflammation induces reactions within the CNS such as central sensitization, which is involved in the mechanism of inflammatory hyperalgesia. However, the precise mechanism of inflammatory signal transmission from the peripheral inflammatory site to the CNS is not clear. We studied the role of circulating interleukin (IL)-6 as a messenger of inflammatory information from the periphery to the CNS. In the rat model of inflammatory hyperalgesia induced by carrageenan, levels of IL-6 but not IL-1β or tumor necrosis factor alpha (TNFα) were significantly elevated in the circulating blood 3 h after an injection of carrageenan. In addition, injecting carrageenan into the hind paw evoked thermal hyperalgesia and the release of prostaglandin E2 (PGE2 ) from isolated blood vessels of the CNS ex vivo, as well as the induction of cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase (mPGES)-1 and nuclear translocation of signal transducer and activator of transcription 3 (STAT3) in vascular endothelial cells of the CNS. A prior i.p. injection of IL-6 antiserum (IL-6AS) abolished or attenuated these responses. The present results suggested that circulating IL-6 could act as a messenger of inflammatory information from peripheral inflammatory sites to the CNS and as the afferent circulating signal to the CNS to produce prostaglandins in the vascular endothelial cells of the CNS through a COX-2 dependent pathway.</description><subject>Afferent Pathways - immunology</subject><subject>Animals</subject><subject>Antibodies - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Central Nervous System - immunology</subject><subject>Cyclooxygenase 2 - blood</subject><subject>Cyclooxygenase 2 - secretion</subject><subject>cyclooxygenase-2</subject><subject>Dinoprostone - blood</subject><subject>Dinoprostone - secretion</subject><subject>Endothelial Cells - immunology</subject><subject>Endothelial Cells - metabolism</subject><subject>Endothelial Cells - secretion</subject><subject>Foot - innervation</subject><subject>Foot - physiopathology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>hyperalgesia</subject><subject>Hyperalgesia - chemically induced</subject><subject>Hyperalgesia - immunology</subject><subject>Hyperalgesia - physiopathology</subject><subject>inflammation</subject><subject>Inflammation - immunology</subject><subject>Inflammation - physiopathology</subject><subject>Inflammation Mediators - adverse effects</subject><subject>Interleukin-6 - antagonists & inhibitors</subject><subject>Interleukin-6 - blood</subject><subject>Interleukin-6 - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Nervous system as a whole</subject><subject>Neurology</subject><subject>Peripheral Nerves - immunology</subject><subject>prostaglandin</subject><subject>Prostaglandin-E Synthases</subject><subject>Prostaglandin-Endoperoxide Synthases - blood</subject><subject>Prostaglandin-Endoperoxide Synthases - secretion</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Sensory Receptor Cells - immunology</subject><subject>Sensory Receptor Cells - physiopathology</subject><subject>Signal Transduction - immunology</subject><subject>STAT3 Transcription Factor - blood</subject><subject>STAT3 Transcription Factor - secretion</subject><subject>Up-Regulation - drug effects</subject><subject>Up-Regulation - physiology</subject><subject>vascular endothelial cells</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkkuLFDEQgIMo7rj6F6QR9NZjXp2e9iDI-FpY9LAK3kKmUsHMdidrkhbm35tmGlY8mUtS1FdV4aMIecHollGmXh-3AecUM3gMgFtOqaqJLe26B2TDdr1o-07Kh2RDBVWt7Di_IE9yPtJ6OikekwvWCyqE2G3Ij6tQMI043_rQqsbnxjRggvXWFGymOCLMIzblpylNSSbkyZfc-OBGM02mxHRagpjq28fQlFhRbPZfbp6SR86MGZ-t9yX5_vHDt_3n9vrrp6v9u-sW5CBLK3rRDwfLKYBU1B3k4BhVu4NiO97zHh1YCcLybpASJHIDANYOYB1VzjEuLsmrc9-7FH_NmIuefAYcRxMwzlmzQQ1DbVXBN2cQqrqc0Om75CeTTppRvXjVR_23V714XXLVay1-vk6ZDxPa-9JVZAVeroDJYEZXVYHP99xOCSWYrNz7M4fVyW-PSa_jrE8IRdvo_-8_b_9pA6MPvk6-xRPmY5xTqNY105lrqm-WTVgWgSrKZE8H8QfgzLMt</recordid><startdate>20070316</startdate><enddate>20070316</enddate><creator>Oka, Y</creator><creator>Ibuki, T</creator><creator>Matsumura, K</creator><creator>Namba, M</creator><creator>Yamazaki, Y</creator><creator>Poole, S</creator><creator>Tanaka, Y</creator><creator>Kobayashi, S</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope></search><sort><creationdate>20070316</creationdate><title>Interleukin-6 is a candidate molecule that transmits inflammatory information to the CNS</title><author>Oka, Y ; Ibuki, T ; Matsumura, K ; Namba, M ; Yamazaki, Y ; Poole, S ; Tanaka, Y ; Kobayashi, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-37379bd20cc460fb49f1068b6182727efcd4c3d25944c4e2acccdd9cdf06ff123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Afferent Pathways - immunology</topic><topic>Animals</topic><topic>Antibodies - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Central Nervous System - immunology</topic><topic>Cyclooxygenase 2 - blood</topic><topic>Cyclooxygenase 2 - secretion</topic><topic>cyclooxygenase-2</topic><topic>Dinoprostone - blood</topic><topic>Dinoprostone - secretion</topic><topic>Endothelial Cells - immunology</topic><topic>Endothelial Cells - metabolism</topic><topic>Endothelial Cells - secretion</topic><topic>Foot - innervation</topic><topic>Foot - physiopathology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>hyperalgesia</topic><topic>Hyperalgesia - chemically induced</topic><topic>Hyperalgesia - immunology</topic><topic>Hyperalgesia - physiopathology</topic><topic>inflammation</topic><topic>Inflammation - immunology</topic><topic>Inflammation - physiopathology</topic><topic>Inflammation Mediators - adverse effects</topic><topic>Interleukin-6 - antagonists & inhibitors</topic><topic>Interleukin-6 - blood</topic><topic>Interleukin-6 - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Nervous system as a whole</topic><topic>Neurology</topic><topic>Peripheral Nerves - immunology</topic><topic>prostaglandin</topic><topic>Prostaglandin-E Synthases</topic><topic>Prostaglandin-Endoperoxide Synthases - blood</topic><topic>Prostaglandin-Endoperoxide Synthases - secretion</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Sensory Receptor Cells - immunology</topic><topic>Sensory Receptor Cells - physiopathology</topic><topic>Signal Transduction - immunology</topic><topic>STAT3 Transcription Factor - blood</topic><topic>STAT3 Transcription Factor - secretion</topic><topic>Up-Regulation - drug effects</topic><topic>Up-Regulation - physiology</topic><topic>vascular endothelial cells</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oka, Y</creatorcontrib><creatorcontrib>Ibuki, T</creatorcontrib><creatorcontrib>Matsumura, K</creatorcontrib><creatorcontrib>Namba, M</creatorcontrib><creatorcontrib>Yamazaki, Y</creatorcontrib><creatorcontrib>Poole, S</creatorcontrib><creatorcontrib>Tanaka, Y</creatorcontrib><creatorcontrib>Kobayashi, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oka, Y</au><au>Ibuki, T</au><au>Matsumura, K</au><au>Namba, M</au><au>Yamazaki, Y</au><au>Poole, S</au><au>Tanaka, Y</au><au>Kobayashi, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin-6 is a candidate molecule that transmits inflammatory information to the CNS</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2007-03-16</date><risdate>2007</risdate><volume>145</volume><issue>2</issue><spage>530</spage><epage>538</epage><pages>530-538</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>Abstract Peripheral inflammation induces reactions within the CNS such as central sensitization, which is involved in the mechanism of inflammatory hyperalgesia. However, the precise mechanism of inflammatory signal transmission from the peripheral inflammatory site to the CNS is not clear. We studied the role of circulating interleukin (IL)-6 as a messenger of inflammatory information from the periphery to the CNS. In the rat model of inflammatory hyperalgesia induced by carrageenan, levels of IL-6 but not IL-1β or tumor necrosis factor alpha (TNFα) were significantly elevated in the circulating blood 3 h after an injection of carrageenan. In addition, injecting carrageenan into the hind paw evoked thermal hyperalgesia and the release of prostaglandin E2 (PGE2 ) from isolated blood vessels of the CNS ex vivo, as well as the induction of cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase (mPGES)-1 and nuclear translocation of signal transducer and activator of transcription 3 (STAT3) in vascular endothelial cells of the CNS. A prior i.p. injection of IL-6 antiserum (IL-6AS) abolished or attenuated these responses. The present results suggested that circulating IL-6 could act as a messenger of inflammatory information from peripheral inflammatory sites to the CNS and as the afferent circulating signal to the CNS to produce prostaglandins in the vascular endothelial cells of the CNS through a COX-2 dependent pathway.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>17303338</pmid><doi>10.1016/j.neuroscience.2006.10.055</doi><tpages>9</tpages></addata></record> |
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| ispartof | Neuroscience, 2007-03, Vol.145 (2), p.530-538 |
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| subjects | Afferent Pathways - immunology Animals Antibodies - pharmacology Biological and medical sciences Central Nervous System - immunology Cyclooxygenase 2 - blood Cyclooxygenase 2 - secretion cyclooxygenase-2 Dinoprostone - blood Dinoprostone - secretion Endothelial Cells - immunology Endothelial Cells - metabolism Endothelial Cells - secretion Foot - innervation Foot - physiopathology Fundamental and applied biological sciences. Psychology hyperalgesia Hyperalgesia - chemically induced Hyperalgesia - immunology Hyperalgesia - physiopathology inflammation Inflammation - immunology Inflammation - physiopathology Inflammation Mediators - adverse effects Interleukin-6 - antagonists & inhibitors Interleukin-6 - blood Interleukin-6 - immunology Male Medical sciences Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Peripheral Nerves - immunology prostaglandin Prostaglandin-E Synthases Prostaglandin-Endoperoxide Synthases - blood Prostaglandin-Endoperoxide Synthases - secretion Rats Rats, Sprague-Dawley Sensory Receptor Cells - immunology Sensory Receptor Cells - physiopathology Signal Transduction - immunology STAT3 Transcription Factor - blood STAT3 Transcription Factor - secretion Up-Regulation - drug effects Up-Regulation - physiology vascular endothelial cells Vertebrates: nervous system and sense organs |
| title | Interleukin-6 is a candidate molecule that transmits inflammatory information to the CNS |
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