Naringenin Regulates CFTR Activation and Expression in Airway Epithelial Cells

Background/Aims: Sputum symptoms are commonly seen in the elderly. This study aimed to identify an efficacious expectorant treatment stratagem through evaluating the secretion-promoting activation and cystic fibrosis transmembrane conductance regulator (CFTR) expression of the bioactive herbal monom...

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Veröffentlicht in:	Cellular Physiology and Biochemistry 2017-01, Vol.44 (3), p.1146-1160
Hauptverfasser:	Shi, Rui, Xiao, Zi-Ting, Zheng, Yi-Jun, Zhang, Yi-Lin, Xu, Jia-Wen, Huang, Jie-Hong, Zhou, Wen-Liang, Li, Pei-Bo, Su, Wei-Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Airway (Medicine) Airway epithelium Animals Barium Compounds - pharmacology Benzoates - pharmacology Care and treatment Cell culture Cells, Cultured Cellular control mechanisms CFTR Chinese medicine Chloride Channels - antagonists & inhibitors Chloride Channels - metabolism Chlorides - pharmacology Cl- secretion Colforsin - pharmacology Cyclic AMP - analysis Cystic fibrosis Cystic Fibrosis Transmembrane Conductance Regulator - antagonists & inhibitors Cystic Fibrosis Transmembrane Conductance Regulator - genetics Cystic Fibrosis Transmembrane Conductance Regulator - metabolism Electrolytes Epithelial cells Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - metabolism Female Flavanones - pharmacology Gene expression Health aspects Humans Imines - pharmacology Ion Transport - drug effects Kinases Laboratory animals Male Microscopy, Fluorescence Naringenin Original Paper ortho-Aminobenzoates - pharmacology Penicillin Physiological aspects Rats Rats, Sprague-Dawley Real-Time Polymerase Chain Reaction Rodents Thiazolidines - pharmacology Trachea - cytology Traditional Chinese medicine
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