Notch ligand Delta-like1 enhances degranulation and cytokine production through a novel Notch/Dok-1/MAPKs pathway in vitro

Food allergy includes sensitization phase and effect phase, and effect cells degranulate and secrete cytokines in the effect phase, causing allergic clinical symptoms. We have demonstrated that Notch signaling plays an important role in the sensitization phase, but its role in effect phases still re...

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Veröffentlicht in:	Immunologic research 2018-02, Vol.66 (1), p.87-96
Hauptverfasser:	Jiang, Songsong, Da, Yifan, Han, Shiwen, He, Yahong, Che, Huilian
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergology Anaphylaxis Anaphylaxis - immunology Animals Basophils - immunology Biomedical and Life Sciences Biomedicine Cell Degranulation Cell Line Cytokines Cytokines - metabolism Degranulation DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Dok1 protein Extracellular Signal-Regulated MAP Kinases - metabolism Female Food allergies Food Hypersensitivity - immunology Immunoglobulin E Immunology Interleukin 13 Interleukin 4 Interleukin 6 Internal Medicine Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Kinases Ligands Medicine/Public Health Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred BALB C Notch protein Original Article Phosphoproteins - genetics Phosphoproteins - metabolism Phosphorylation Priming Rats Receptors Receptors, Notch - metabolism Recombinant Fusion Proteins - genetics RNA, Small Interfering - genetics RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Secretase Signal Transduction T cell receptors Tyrosine
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