Sodium Tanshinone Ⅱ A Sulfonate Injection as Adjuvant Treatment for Unstable Angina Pectoris: A Meta-Analysis of 17 Randomized Controlled Trials
Objective: To systematically evaluate the effectiveness and safety of Sodium Tanshinone ⅡA Sulfonate Injection(STS) as one adjuvant therapy for treating unstable angina pectoris(UAP). Methods: Randomized controlled trials(RCTs) of UAP treated by STS were searched in the China National Knowledge Infr...
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Veröffentlicht in: | Chinese journal of integrative medicine 2018-02, Vol.24 (2), p.156-160 |
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description | Objective: To systematically evaluate the effectiveness and safety of Sodium Tanshinone ⅡA Sulfonate Injection(STS) as one adjuvant therapy for treating unstable angina pectoris(UAP). Methods: Randomized controlled trials(RCTs) of UAP treated by STS were searched in the China National Knowledge Infrastructure Database(CNKI), VIP Database for Chinese Technical Periodicals(VIP), Wanfang Database, the Chinese Biomedical Literature Database(CBM), Web of Science, the Cochrane Library, Embase, and Pub Med, which from inception to January, 2016. The Cochrane Risk Assessment Tool was used to evaluate the methodological quality of the RCTs. The Review Manager 5.3 software was used to conduct the metaanalysis. Results: The results showed that 17 RCTs involving 1,372 patients were included. The meta-analysis indicated that the combined use of STS and Western medicine(WM) in the treatment of UAP can obviously improve the total effective rate [risk ratio(RR)=1.31, 95% confidence interval(CI)(1.24,1.39), P〈0.0001], and the total effective rate of electrocardiogram [RR=1.43, 95% CI(1.30,1.56), P〈0.0001], decrease the level of CRP [mean difference(MD)=–3.06, 95%CI(–3.85, –2.27), P〈0.00001], fibrinogen [MD=–1.03, 95% CI(–1.16, –0.89), P〈0.00001], and whole blood high shear viscosity [MD=–0.70, 95% CI(–0.92, –0.49), P〈0.00001]. Additionally, the occurrence of adverse drug reaction of the experimental group was significantly higher than that of the control group [RR=3.57, 95% CI(1.28, 9.94), P〈0.05]. Conclusions: Compared with WM, the combined use of STS was more effective. |
doi_str_mv | 10.1007/s11655-017-2424-x |
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Methods: Randomized controlled trials(RCTs) of UAP treated by STS were searched in the China National Knowledge Infrastructure Database(CNKI), VIP Database for Chinese Technical Periodicals(VIP), Wanfang Database, the Chinese Biomedical Literature Database(CBM), Web of Science, the Cochrane Library, Embase, and Pub Med, which from inception to January, 2016. The Cochrane Risk Assessment Tool was used to evaluate the methodological quality of the RCTs. The Review Manager 5.3 software was used to conduct the metaanalysis. Results: The results showed that 17 RCTs involving 1,372 patients were included. The meta-analysis indicated that the combined use of STS and Western medicine(WM) in the treatment of UAP can obviously improve the total effective rate [risk ratio(RR)=1.31, 95% confidence interval(CI)(1.24,1.39), P〈0.0001], and the total effective rate of electrocardiogram [RR=1.43, 95% CI(1.30,1.56), P〈0.0001], decrease the level of CRP [mean difference(MD)=–3.06, 95%CI(–3.85, –2.27), P〈0.00001], fibrinogen [MD=–1.03, 95% CI(–1.16, –0.89), P〈0.00001], and whole blood high shear viscosity [MD=–0.70, 95% CI(–0.92, –0.49), P〈0.00001]. Additionally, the occurrence of adverse drug reaction of the experimental group was significantly higher than that of the control group [RR=3.57, 95% CI(1.28, 9.94), P〈0.05]. Conclusions: Compared with WM, the combined use of STS was more effective.</description><identifier>ISSN: 1672-0415</identifier><identifier>EISSN: 1993-0402</identifier><identifier>DOI: 10.1007/s11655-017-2424-x</identifier><identifier>PMID: 29181731</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Evidence-Based Integrative Medicine ; Medicine ; Medicine & Public Health ; 辅助治疗;心绞痛;不稳定;随机化;控制;注射;审判;结构数据库</subject><ispartof>Chinese journal of integrative medicine, 2018-02, Vol.24 (2), p.156-160</ispartof><rights>Chinese Association of the Integration of Traditional and Western Medicine 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-a02657403034e04857f418b84bd3b84cddaec4238b092256aa10b62d1aeb3a443</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/86437A/86437A.jpg</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11655-017-2424-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11655-017-2424-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29181731$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tan, Di</creatorcontrib><creatorcontrib>Wu, Jia-rui</creatorcontrib><creatorcontrib>Zhang, Xiao-meng</creatorcontrib><creatorcontrib>Liu, Shi</creatorcontrib><creatorcontrib>Zhang, Bing</creatorcontrib><title>Sodium Tanshinone Ⅱ A Sulfonate Injection as Adjuvant Treatment for Unstable Angina Pectoris: A Meta-Analysis of 17 Randomized Controlled Trials</title><title>Chinese journal of integrative medicine</title><addtitle>Chin. J. Integr. Med</addtitle><addtitle>Chinese Journal of Integrative Medicine</addtitle><description>Objective: To systematically evaluate the effectiveness and safety of Sodium Tanshinone ⅡA Sulfonate Injection(STS) as one adjuvant therapy for treating unstable angina pectoris(UAP). Methods: Randomized controlled trials(RCTs) of UAP treated by STS were searched in the China National Knowledge Infrastructure Database(CNKI), VIP Database for Chinese Technical Periodicals(VIP), Wanfang Database, the Chinese Biomedical Literature Database(CBM), Web of Science, the Cochrane Library, Embase, and Pub Med, which from inception to January, 2016. The Cochrane Risk Assessment Tool was used to evaluate the methodological quality of the RCTs. The Review Manager 5.3 software was used to conduct the metaanalysis. Results: The results showed that 17 RCTs involving 1,372 patients were included. The meta-analysis indicated that the combined use of STS and Western medicine(WM) in the treatment of UAP can obviously improve the total effective rate [risk ratio(RR)=1.31, 95% confidence interval(CI)(1.24,1.39), P〈0.0001], and the total effective rate of electrocardiogram [RR=1.43, 95% CI(1.30,1.56), P〈0.0001], decrease the level of CRP [mean difference(MD)=–3.06, 95%CI(–3.85, –2.27), P〈0.00001], fibrinogen [MD=–1.03, 95% CI(–1.16, –0.89), P〈0.00001], and whole blood high shear viscosity [MD=–0.70, 95% CI(–0.92, –0.49), P〈0.00001]. Additionally, the occurrence of adverse drug reaction of the experimental group was significantly higher than that of the control group [RR=3.57, 95% CI(1.28, 9.94), P〈0.05]. Conclusions: Compared with WM, the combined use of STS was more effective.</description><subject>Evidence-Based Integrative Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>辅助治疗;心绞痛;不稳定;随机化;控制;注射;审判;结构数据库</subject><issn>1672-0415</issn><issn>1993-0402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9UUtuFDEUtBCIhMAB2CCLFZsGf9vdy9YohEhBIDJZW6_b7olH3XZiu1HCPjdgxY57cBouwBVwNEOWbN4r6VWVnqoQeknJW0qIepcoraWsCFUVE0xUN4_QIW1bXhFB2OOCa8UKpvIAPUtpS4hUNZFP0QFraUMVp4fo-3kwbpnxGny6dD54i3_f_cQdPl-mMXjIFp_6rR2yCx5Dwp3ZLl_BZ7yOFvJsCxpDxBc-Zegnizu_cR7w56II0aU_v34Ur482Q9V5mG6TSziMmCr8BbwJs_tmDV4Fn2OYpgLX0cGUnqMnY1n2xX4foYv3x-vVh-rs08npqjurBq5oroCwWipBOOHCEtFINQra9I3oDS9zMAbsIBhvetIyJmsASvqaGQq25yAEP0Jvdr5XMVwvNmU9uzTYaQJvw5I0beu2KEu2hUp31CGGlKId9VV0M8RbTYm-L0PvytClDH1fhr4pmld7-6WfrXlQ_Eu_ENiOkMrJb2zU27DEklP6r-vr_SeXwW-ui-7BuFZCSS7ahv8F6QKjcw</recordid><startdate>20180201</startdate><enddate>20180201</enddate><creator>Tan, Di</creator><creator>Wu, Jia-rui</creator><creator>Zhang, Xiao-meng</creator><creator>Liu, Shi</creator><creator>Zhang, Bing</creator><general>Springer Berlin Heidelberg</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20180201</creationdate><title>Sodium Tanshinone Ⅱ A Sulfonate Injection as Adjuvant Treatment for Unstable Angina Pectoris: A Meta-Analysis of 17 Randomized Controlled Trials</title><author>Tan, Di ; Wu, Jia-rui ; Zhang, Xiao-meng ; Liu, Shi ; Zhang, Bing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-a02657403034e04857f418b84bd3b84cddaec4238b092256aa10b62d1aeb3a443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Evidence-Based Integrative Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>辅助治疗;心绞痛;不稳定;随机化;控制;注射;审判;结构数据库</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tan, Di</creatorcontrib><creatorcontrib>Wu, Jia-rui</creatorcontrib><creatorcontrib>Zhang, Xiao-meng</creatorcontrib><creatorcontrib>Liu, Shi</creatorcontrib><creatorcontrib>Zhang, Bing</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chinese journal of integrative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tan, Di</au><au>Wu, Jia-rui</au><au>Zhang, Xiao-meng</au><au>Liu, Shi</au><au>Zhang, Bing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sodium Tanshinone Ⅱ A Sulfonate Injection as Adjuvant Treatment for Unstable Angina Pectoris: A Meta-Analysis of 17 Randomized Controlled Trials</atitle><jtitle>Chinese journal of integrative medicine</jtitle><stitle>Chin. J. Integr. Med</stitle><addtitle>Chinese Journal of Integrative Medicine</addtitle><date>2018-02-01</date><risdate>2018</risdate><volume>24</volume><issue>2</issue><spage>156</spage><epage>160</epage><pages>156-160</pages><issn>1672-0415</issn><eissn>1993-0402</eissn><abstract>Objective: To systematically evaluate the effectiveness and safety of Sodium Tanshinone ⅡA Sulfonate Injection(STS) as one adjuvant therapy for treating unstable angina pectoris(UAP). Methods: Randomized controlled trials(RCTs) of UAP treated by STS were searched in the China National Knowledge Infrastructure Database(CNKI), VIP Database for Chinese Technical Periodicals(VIP), Wanfang Database, the Chinese Biomedical Literature Database(CBM), Web of Science, the Cochrane Library, Embase, and Pub Med, which from inception to January, 2016. The Cochrane Risk Assessment Tool was used to evaluate the methodological quality of the RCTs. The Review Manager 5.3 software was used to conduct the metaanalysis. Results: The results showed that 17 RCTs involving 1,372 patients were included. The meta-analysis indicated that the combined use of STS and Western medicine(WM) in the treatment of UAP can obviously improve the total effective rate [risk ratio(RR)=1.31, 95% confidence interval(CI)(1.24,1.39), P〈0.0001], and the total effective rate of electrocardiogram [RR=1.43, 95% CI(1.30,1.56), P〈0.0001], decrease the level of CRP [mean difference(MD)=–3.06, 95%CI(–3.85, –2.27), P〈0.00001], fibrinogen [MD=–1.03, 95% CI(–1.16, –0.89), P〈0.00001], and whole blood high shear viscosity [MD=–0.70, 95% CI(–0.92, –0.49), P〈0.00001]. Additionally, the occurrence of adverse drug reaction of the experimental group was significantly higher than that of the control group [RR=3.57, 95% CI(1.28, 9.94), P〈0.05]. Conclusions: Compared with WM, the combined use of STS was more effective.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>29181731</pmid><doi>10.1007/s11655-017-2424-x</doi><tpages>5</tpages></addata></record> |
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subjects | Evidence-Based Integrative Medicine Medicine Medicine & Public Health 辅助治疗 心绞痛 不稳定 随机化 控制 注射 审判 结构数据库 |
title | Sodium Tanshinone Ⅱ A Sulfonate Injection as Adjuvant Treatment for Unstable Angina Pectoris: A Meta-Analysis of 17 Randomized Controlled Trials |
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