The protective effects of melatonin and Vitamin E on antioxidant enzyme activities and epididymal sperm characteristics of homocysteine treated male rats
The aims of this study were to investigate the effects of homocysteine (Hcy) on epididymal sperm characteristics, plasma testosterone level and biochemical changes related to oxidative stress and to examine the effects of melatonin (Mlt) or Vitamin E (VE) administration on these parameters in Hcy-tr...
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| Veröffentlicht in: | Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2007-02, Vol.23 (2), p.226-231 |
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| creator | Sonmez, M Yuce, A Turk, G |
| description | The aims of this study were to investigate the effects of homocysteine (Hcy) on epididymal sperm characteristics, plasma testosterone level and biochemical changes related to oxidative stress and to examine the effects of melatonin (Mlt) or Vitamin E (VE) administration on these parameters in Hcy-treated male rats. In this study, 32 adult male albino rats of Wistar strain were used. The rats were randomly divided into four groups. The first group of rats received only Hcy (0.71
mg/kg/day) intraperitonially (ip) for 6 weeks. The second group of rats was given Hcy along with simultaneous administration of Mlt (1
mg/kg/day) subcutaneously. The third group of rats received Hcy along with simultaneous administration of VE (125
mg/kg/day, ip). The fourth group of rats served as control during 6 weeks and was daily given 0.1
mL of physiological saline (NaCl, 0.9%) ip. While the plasma malondialdehyde level significantly (
p
<
0.05) increased, the plasma superoxide dismutase, glutathione peroxidase and catalase activities significantly (
p
<
0.05) decreased in Hcy-treated rats when compared to control rats. Furthermore, the epididymal sperm concentration, the percentage of progressive sperm motility and plasma testosterone level were significantly (
p
<
0.05) lower in Hcy-treated rats than those of the control rats. The simultaneous administration of Mlt or VE to Hcy-treated animals impeded the decrease in the plasma antioxidant enzyme activities, testosterone level, the epididymal sperm concentration and motility. In conclusion, this study indicates that chronic administration of Hcy has the harmful effect on the epididymal sperm characteristics of male rats. The administration of Mlt or VE can prevent adverse effects of Hcy on the plasma antioxidant enzyme activities, testosterone level, epididymal sperm count and motility in male rats. |
| doi_str_mv | 10.1016/j.reprotox.2006.11.003 |
| format | Article |
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mg/kg/day) intraperitonially (ip) for 6 weeks. The second group of rats was given Hcy along with simultaneous administration of Mlt (1
mg/kg/day) subcutaneously. The third group of rats received Hcy along with simultaneous administration of VE (125
mg/kg/day, ip). The fourth group of rats served as control during 6 weeks and was daily given 0.1
mL of physiological saline (NaCl, 0.9%) ip. While the plasma malondialdehyde level significantly (
p
<
0.05) increased, the plasma superoxide dismutase, glutathione peroxidase and catalase activities significantly (
p
<
0.05) decreased in Hcy-treated rats when compared to control rats. Furthermore, the epididymal sperm concentration, the percentage of progressive sperm motility and plasma testosterone level were significantly (
p
<
0.05) lower in Hcy-treated rats than those of the control rats. The simultaneous administration of Mlt or VE to Hcy-treated animals impeded the decrease in the plasma antioxidant enzyme activities, testosterone level, the epididymal sperm concentration and motility. In conclusion, this study indicates that chronic administration of Hcy has the harmful effect on the epididymal sperm characteristics of male rats. The administration of Mlt or VE can prevent adverse effects of Hcy on the plasma antioxidant enzyme activities, testosterone level, epididymal sperm count and motility in male rats.</description><identifier>ISSN: 0890-6238</identifier><identifier>EISSN: 1873-1708</identifier><identifier>DOI: 10.1016/j.reprotox.2006.11.003</identifier><identifier>PMID: 17178211</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Antioxidants - metabolism ; Antioxidants - pharmacology ; Biological and medical sciences ; Catalase - blood ; Drug Therapy, Combination ; Embryology: invertebrates and vertebrates. Teratology ; Epididymis - drug effects ; Epididymis - physiology ; Fundamental and applied biological sciences. Psychology ; Genitalia, Male - drug effects ; Glutathione Peroxidase - blood ; Homocysteine ; Homocysteine - toxicity ; Injections, Intraperitoneal ; Lipid peroxidation ; Male ; Malondialdehyde - blood ; Medical sciences ; Melatonin ; Melatonin - pharmacology ; Organ Size - drug effects ; Oxidative Stress - drug effects ; Oxidoreductases - blood ; Rat ; Rats ; Rats, Wistar ; Sperm ; Sperm Motility - drug effects ; Sperm Motility - physiology ; Spermatozoa - drug effects ; Spermatozoa - physiology ; Superoxide Dismutase - blood ; Teratology. Teratogens ; Testosterone - blood ; Toxicology ; Vitamin E ; Vitamin E - pharmacology</subject><ispartof>Reproductive toxicology (Elmsford, N.Y.), 2007-02, Vol.23 (2), p.226-231</ispartof><rights>2006 Elsevier Inc.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-3e5b2b25911c83edb0baa99e13a593671d2f8b1abee6f52b1ae74a7065bb47373</citedby><cites>FETCH-LOGICAL-c427t-3e5b2b25911c83edb0baa99e13a593671d2f8b1abee6f52b1ae74a7065bb47373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.reprotox.2006.11.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18535737$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17178211$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sonmez, M</creatorcontrib><creatorcontrib>Yuce, A</creatorcontrib><creatorcontrib>Turk, G</creatorcontrib><title>The protective effects of melatonin and Vitamin E on antioxidant enzyme activities and epididymal sperm characteristics of homocysteine treated male rats</title><title>Reproductive toxicology (Elmsford, N.Y.)</title><addtitle>Reprod Toxicol</addtitle><description>The aims of this study were to investigate the effects of homocysteine (Hcy) on epididymal sperm characteristics, plasma testosterone level and biochemical changes related to oxidative stress and to examine the effects of melatonin (Mlt) or Vitamin E (VE) administration on these parameters in Hcy-treated male rats. In this study, 32 adult male albino rats of Wistar strain were used. The rats were randomly divided into four groups. The first group of rats received only Hcy (0.71
mg/kg/day) intraperitonially (ip) for 6 weeks. The second group of rats was given Hcy along with simultaneous administration of Mlt (1
mg/kg/day) subcutaneously. The third group of rats received Hcy along with simultaneous administration of VE (125
mg/kg/day, ip). The fourth group of rats served as control during 6 weeks and was daily given 0.1
mL of physiological saline (NaCl, 0.9%) ip. While the plasma malondialdehyde level significantly (
p
<
0.05) increased, the plasma superoxide dismutase, glutathione peroxidase and catalase activities significantly (
p
<
0.05) decreased in Hcy-treated rats when compared to control rats. Furthermore, the epididymal sperm concentration, the percentage of progressive sperm motility and plasma testosterone level were significantly (
p
<
0.05) lower in Hcy-treated rats than those of the control rats. The simultaneous administration of Mlt or VE to Hcy-treated animals impeded the decrease in the plasma antioxidant enzyme activities, testosterone level, the epididymal sperm concentration and motility. In conclusion, this study indicates that chronic administration of Hcy has the harmful effect on the epididymal sperm characteristics of male rats. The administration of Mlt or VE can prevent adverse effects of Hcy on the plasma antioxidant enzyme activities, testosterone level, epididymal sperm count and motility in male rats.</description><subject>Animals</subject><subject>Antioxidants - metabolism</subject><subject>Antioxidants - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Catalase - blood</subject><subject>Drug Therapy, Combination</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Epididymis - drug effects</subject><subject>Epididymis - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genitalia, Male - drug effects</subject><subject>Glutathione Peroxidase - blood</subject><subject>Homocysteine</subject><subject>Homocysteine - toxicity</subject><subject>Injections, Intraperitoneal</subject><subject>Lipid peroxidation</subject><subject>Male</subject><subject>Malondialdehyde - blood</subject><subject>Medical sciences</subject><subject>Melatonin</subject><subject>Melatonin - pharmacology</subject><subject>Organ Size - drug effects</subject><subject>Oxidative Stress - drug effects</subject><subject>Oxidoreductases - blood</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sperm</subject><subject>Sperm Motility - drug effects</subject><subject>Sperm Motility - physiology</subject><subject>Spermatozoa - drug effects</subject><subject>Spermatozoa - physiology</subject><subject>Superoxide Dismutase - blood</subject><subject>Teratology. Teratogens</subject><subject>Testosterone - blood</subject><subject>Toxicology</subject><subject>Vitamin E</subject><subject>Vitamin E - pharmacology</subject><issn>0890-6238</issn><issn>1873-1708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u2zAMxoVhxZq1e4VCl-1mT7Riy75tKLo_QIFd2l4FWqIRBbaVSUrR9E32tpObDD3uxA_E7yMJfoxdgShBQPN5WwbaBZ_8U1kJ0ZQApRDyDVtBq2QBSrRv2Uq0nSiaSrbn7H2MWyHEWnXqHTsHBaqtAFbsz92G-DKITHKPxGkYsorcD3yiEZOf3cxxtvzBJZyyvuF-aSTnn5zNldP8fJiI4-J3yVF8wWnnrLOHCUcedxQmbjYYMkPBxeTMy4KNn7w5xERuJp4CYSLLs4N4wBQv2dmAY6QPp3rB7r_d3F3_KG5_ff95_fW2MOtKpUJS3Vd9VXcAppVke9Ejdh2BxLqTjQJbDW0P2BM1Q11lRWqNSjR136-VVPKCfTrOzV_4vaeY9OSioXHEmfw-auiarm66NoPNETTBxxho0LvgJgwHDUIvoeit_heKXkLRADqHko1Xpw37fiL7ajulkIGPJwCjwXEIOBsXX7m2lvXx1C9HjvI_Hh0FHY2j2ZB1IaemrXf_u-UvZwizHw</recordid><startdate>20070201</startdate><enddate>20070201</enddate><creator>Sonmez, M</creator><creator>Yuce, A</creator><creator>Turk, G</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20070201</creationdate><title>The protective effects of melatonin and Vitamin E on antioxidant enzyme activities and epididymal sperm characteristics of homocysteine treated male rats</title><author>Sonmez, M ; Yuce, A ; Turk, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-3e5b2b25911c83edb0baa99e13a593671d2f8b1abee6f52b1ae74a7065bb47373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Antioxidants - metabolism</topic><topic>Antioxidants - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Catalase - blood</topic><topic>Drug Therapy, Combination</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Epididymis - drug effects</topic><topic>Epididymis - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genitalia, Male - drug effects</topic><topic>Glutathione Peroxidase - blood</topic><topic>Homocysteine</topic><topic>Homocysteine - toxicity</topic><topic>Injections, Intraperitoneal</topic><topic>Lipid peroxidation</topic><topic>Male</topic><topic>Malondialdehyde - blood</topic><topic>Medical sciences</topic><topic>Melatonin</topic><topic>Melatonin - pharmacology</topic><topic>Organ Size - drug effects</topic><topic>Oxidative Stress - drug effects</topic><topic>Oxidoreductases - blood</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sperm</topic><topic>Sperm Motility - drug effects</topic><topic>Sperm Motility - physiology</topic><topic>Spermatozoa - drug effects</topic><topic>Spermatozoa - physiology</topic><topic>Superoxide Dismutase - blood</topic><topic>Teratology. Teratogens</topic><topic>Testosterone - blood</topic><topic>Toxicology</topic><topic>Vitamin E</topic><topic>Vitamin E - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sonmez, M</creatorcontrib><creatorcontrib>Yuce, A</creatorcontrib><creatorcontrib>Turk, G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Reproductive toxicology (Elmsford, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sonmez, M</au><au>Yuce, A</au><au>Turk, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The protective effects of melatonin and Vitamin E on antioxidant enzyme activities and epididymal sperm characteristics of homocysteine treated male rats</atitle><jtitle>Reproductive toxicology (Elmsford, N.Y.)</jtitle><addtitle>Reprod Toxicol</addtitle><date>2007-02-01</date><risdate>2007</risdate><volume>23</volume><issue>2</issue><spage>226</spage><epage>231</epage><pages>226-231</pages><issn>0890-6238</issn><eissn>1873-1708</eissn><abstract>The aims of this study were to investigate the effects of homocysteine (Hcy) on epididymal sperm characteristics, plasma testosterone level and biochemical changes related to oxidative stress and to examine the effects of melatonin (Mlt) or Vitamin E (VE) administration on these parameters in Hcy-treated male rats. In this study, 32 adult male albino rats of Wistar strain were used. The rats were randomly divided into four groups. The first group of rats received only Hcy (0.71
mg/kg/day) intraperitonially (ip) for 6 weeks. The second group of rats was given Hcy along with simultaneous administration of Mlt (1
mg/kg/day) subcutaneously. The third group of rats received Hcy along with simultaneous administration of VE (125
mg/kg/day, ip). The fourth group of rats served as control during 6 weeks and was daily given 0.1
mL of physiological saline (NaCl, 0.9%) ip. While the plasma malondialdehyde level significantly (
p
<
0.05) increased, the plasma superoxide dismutase, glutathione peroxidase and catalase activities significantly (
p
<
0.05) decreased in Hcy-treated rats when compared to control rats. Furthermore, the epididymal sperm concentration, the percentage of progressive sperm motility and plasma testosterone level were significantly (
p
<
0.05) lower in Hcy-treated rats than those of the control rats. The simultaneous administration of Mlt or VE to Hcy-treated animals impeded the decrease in the plasma antioxidant enzyme activities, testosterone level, the epididymal sperm concentration and motility. In conclusion, this study indicates that chronic administration of Hcy has the harmful effect on the epididymal sperm characteristics of male rats. The administration of Mlt or VE can prevent adverse effects of Hcy on the plasma antioxidant enzyme activities, testosterone level, epididymal sperm count and motility in male rats.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>17178211</pmid><doi>10.1016/j.reprotox.2006.11.003</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0890-6238 |
| ispartof | Reproductive toxicology (Elmsford, N.Y.), 2007-02, Vol.23 (2), p.226-231 |
| issn | 0890-6238 1873-1708 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_19695698 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antioxidants - metabolism Antioxidants - pharmacology Biological and medical sciences Catalase - blood Drug Therapy, Combination Embryology: invertebrates and vertebrates. Teratology Epididymis - drug effects Epididymis - physiology Fundamental and applied biological sciences. Psychology Genitalia, Male - drug effects Glutathione Peroxidase - blood Homocysteine Homocysteine - toxicity Injections, Intraperitoneal Lipid peroxidation Male Malondialdehyde - blood Medical sciences Melatonin Melatonin - pharmacology Organ Size - drug effects Oxidative Stress - drug effects Oxidoreductases - blood Rat Rats Rats, Wistar Sperm Sperm Motility - drug effects Sperm Motility - physiology Spermatozoa - drug effects Spermatozoa - physiology Superoxide Dismutase - blood Teratology. Teratogens Testosterone - blood Toxicology Vitamin E Vitamin E - pharmacology |
| title | The protective effects of melatonin and Vitamin E on antioxidant enzyme activities and epididymal sperm characteristics of homocysteine treated male rats |
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