Rapamycin enhances the number of alloantigen-induced human CD103+CD8+ regulatory T cells in vitro

Regulatory T cells (T(reg) cells) may be operational in both the induction and maintenance of transplantation tolerance. We recently showed that alloantigen-induced CD103+ CD8+ T cells strongly suppressed T-cell proliferation in mixed lymphocyte culture (MLC) via a contact-dependent mechanism. CD103...

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Veröffentlicht in:	Transplantation 2007-04, Vol.83 (8), p.1098-1106
Hauptverfasser:	USS, Elena, YONG, Si-La, HOOIBRINK, Berend, VAN LIER, Rene A. W, TEN BERG, Ineke J. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antigens, CD - immunology Biological and medical sciences Calcineurin - metabolism Calcineurin Inhibitors CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Differentiation Cell Proliferation Cells, Cultured Dendritic Cells - drug effects Dendritic Cells - immunology Dendritic Cells - metabolism Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Integrin alpha Chains - immunology Isoantigens - immunology Medical sciences Pharmacology. Drug treatments Prednisolone - pharmacology Sirolimus - pharmacology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue, organ and graft immunology
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