An Antiproliferative Bis-prenylated Quinone from the New Zealand Brown Alga Perithalia capillaris

Bioactivity-directed isolation work on the endemic New Zealand brown alga Perithalia capillaris, seeking anti-inflammatory compounds, led to a new bis-prenylated quinone (4). This compound inhibited superoxide production by human neutrophils in vitro (IC50 2.1 µM), but was more potent at inhibiting...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2007-12, Vol.70 (12), p.2042-2044
Hauptverfasser:	Sansom, Catherine E, Larsen, Lesley, Perry, Nigel B, Berridge, Michael V, Chia, Elizabeth W, Harper, Jacquie L, Webb, Victoria L
Format:	Artikel
Sprache:	eng
Schlagworte:	algae and seaweeds Animals anti-inflammatory activity anticarcinogenic activity Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences cell proliferation chemical structure cultured cells cytotoxicity General pharmacology HL-60 Cells Humans Marine Medical sciences Molecular Structure neutrophils Neutrophils - drug effects New Zealand Nuclear Magnetic Resonance, Biomolecular Perithalia capillaris Phaeophyceae Phaeophyceae - chemistry Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phenols quinones Quinones - chemistry Quinones - isolation & purification Quinones - pharmacology spectral analysis Sporochnales Superoxides - blood
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