Efficacy of the Third-generation Bisphosphonate Risedronate Alone and in Combination with Anticancer Drugs Against Osteosarcoma Cell Lines

Background: Bisphosphonates (BPs) are currently the most important class of inhibitors of osteoclast-mediated bone resorption and are widely used in the treatment of osteoporosis and other osteoclast-mediated bone diseases. Recently, there has been increasing evidence that BPs also exhibit direct an...

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Veröffentlicht in:	Anticancer research 2008-07, Vol.28 (4B), p.2147-2154
Hauptverfasser:	MURAYAMA, Takashi, KAWASOE, Yasuomi, YAMASHITA, Yoshitaka, UENO, Yoshinori, MINAMI, Syusaku, YOKOUCHI, Masahiro, KOMIYA, Setsuro
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols - pharmacology Apoptosis - drug effects Biological and medical sciences Bone Density Conservation Agents - administration & dosage Bone Density Conservation Agents - pharmacology Bone Neoplasms - drug therapy Bone Neoplasms - metabolism Bone Neoplasms - pathology Carboplatin - administration & dosage Cell Line, Tumor Diseases of the osteoarticular system Doxorubicin - administration & dosage Drug Synergism Etidronic Acid - administration & dosage Etidronic Acid - analogs & derivatives Etidronic Acid - pharmacology Etoposide - administration & dosage GTP-Binding Proteins - metabolism Humans Medical sciences Osteosarcoma - drug therapy Osteosarcoma - metabolism Osteosarcoma - pathology Prenylation - drug effects Risedronate Sodium Tumors Tumors of striated muscle and skeleton Vincristine - administration & dosage
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