Adverse Cardiovascular Effects of Acute Salt Loading in Young Normotensive Individuals
We sought to explore the effects of salt loading in young normotensives on vascular endothelial function, echocardiographic left ventricular diastolic function, and electrocardiographic QT dispersion. Sixteen healthy normotensive male volunteers were randomized in a double-blind crossover fashion to...
Gespeichert in:
| Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 2008-06, Vol.51 (6), p.1525-1530 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1530 |
|---|---|
| container_issue | 6 |
| container_start_page | 1525 |
| container_title | Hypertension (Dallas, Tex. 1979) |
| container_volume | 51 |
| creator | Tzemos, Nikolaos Lim, Pitt O Wong, Suzanne Struthers, Allan D MacDonald, Thomas M |
| description | We sought to explore the effects of salt loading in young normotensives on vascular endothelial function, echocardiographic left ventricular diastolic function, and electrocardiographic QT dispersion. Sixteen healthy normotensive male volunteers were randomized in a double-blind crossover fashion to 5-day treatment periods with either placebo or salt tablets (200 mmol/d of sodium) separated by a 2-week washout period. Throughout the study the volunteers were asked to maintain a low-salt diet. Forearm venous occlusion plethysmography and intraarterial infusions of acetylcholine (ACh), sodium nitroprusside (SNP), and N-monomethyl-l-arginine (L-NMMA) were used to assess vascular reactivity. Baseline and postsalt loading 12-lead ECGs and echocardiograms were also obtained. Twenty-four-hour ambulatory systolic blood pressure rose (117±11 to 121±8 mm Hg) significantly with salt loading. The endothelium-dependent responses to ACh were significantly blunted with salt compared to placebo (ΔFBF% 403 [50] versus 296 [31]; P |
| doi_str_mv | 10.1161/HYPERTENSIONAHA.108.109868 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_19687983</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>19687983</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5831-bdf23e6a9eb868fa38dbc621e6460a34ebb749255c3868e1081c199ee2f7396b3</originalsourceid><addsrcrecordid>eNpdkG1v0zAQgC0EYt3gLyALCb5l89mOa_MtqgqtVHXTNhD7FDnOmQXSeNhJp_17jFoNCUunO9vP-eUh5D2wcwAFF6u7q-X17XJ7s77cVqvqHJjOYbTSL8gMSi4LWSrxkswYGFkYgO8n5DSln4yBlHL-mpyAlqUGJWbkW9XuMSakCxvbLuxtclNvI116j25MNHhauWlEemP7kW6CbbvhB-0GehemXGxD3IURh9Ttka6Httt37WT79Ia88jnh22M-I18_L28Xq2Jz-WW9qDaFK7WAomk9F6iswSa_3luh28YpDqikYlZIbJq5NLwsncj7mD8KDoxB5H4ujGrEGfl4OPchht8TprHedclh39sBw5RqMErPjRYZ_HQAXQwpRfT1Q-x2Nj7VwOq_Vuv_rOZ1XR-s5uZ3x1umZoftv9ajxgx8OALZn-19tIPr0jPHmTACQGZOHrjH0I9Z-69-esRY32OWe1-zPCRXuuCMaabyrMjBQfwBrUWSHA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19687983</pqid></control><display><type>article</type><title>Adverse Cardiovascular Effects of Acute Salt Loading in Young Normotensive Individuals</title><source>MEDLINE</source><source>American Heart Association Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Journals@Ovid Complete</source><creator>Tzemos, Nikolaos ; Lim, Pitt O ; Wong, Suzanne ; Struthers, Allan D ; MacDonald, Thomas M</creator><creatorcontrib>Tzemos, Nikolaos ; Lim, Pitt O ; Wong, Suzanne ; Struthers, Allan D ; MacDonald, Thomas M</creatorcontrib><description>We sought to explore the effects of salt loading in young normotensives on vascular endothelial function, echocardiographic left ventricular diastolic function, and electrocardiographic QT dispersion. Sixteen healthy normotensive male volunteers were randomized in a double-blind crossover fashion to 5-day treatment periods with either placebo or salt tablets (200 mmol/d of sodium) separated by a 2-week washout period. Throughout the study the volunteers were asked to maintain a low-salt diet. Forearm venous occlusion plethysmography and intraarterial infusions of acetylcholine (ACh), sodium nitroprusside (SNP), and N-monomethyl-l-arginine (L-NMMA) were used to assess vascular reactivity. Baseline and postsalt loading 12-lead ECGs and echocardiograms were also obtained. Twenty-four-hour ambulatory systolic blood pressure rose (117±11 to 121±8 mm Hg) significantly with salt loading. The endothelium-dependent responses to ACh were significantly blunted with salt compared to placebo (ΔFBF% 403 [50] versus 296 [31]; P<0.05) and L-NMMA (ΔFBF% −47.2 [4] versus −31 [3]; P<0.01). In contrast, the endothelium-independent response to SNP was not different between treatments. Color M-mode flow propagation velocity (CMMFPV), a preload index of left ventricular diastolic function, was significantly reduced with salt (64 [6] versus 59 [16] cm/s; P<0.05) suggesting increased ventricular stiffness. QT dispersion was also significantly increased with salt (58 [16] versus 48 [17] ms; P=0.02). Salt loading impaired vascular endothelial function, left ventricular mechanical relaxation, and electric repolarization in young healthy normotensives.</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/HYPERTENSIONAHA.108.109868</identifier><identifier>PMID: 18458163</identifier><identifier>CODEN: HPRTDN</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Acetylcholine - administration & dosage ; Acute Disease ; Adult ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure - drug effects ; Blood Pressure - physiology ; Cardiology. Vascular system ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Cross-Over Studies ; Diastole - drug effects ; Diastole - physiology ; Diet, Sodium-Restricted ; Echocardiography ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - physiology ; Enzyme Inhibitors - administration & dosage ; Humans ; Hypertension - physiopathology ; Male ; Medical sciences ; Nitroprusside - administration & dosage ; omega-N-Methylarginine - administration & dosage ; Sodium Chloride, Dietary - adverse effects ; Vasoconstriction - drug effects ; Vasoconstriction - physiology ; Vasodilator Agents - administration & dosage ; Ventricular Function, Left - drug effects ; Ventricular Function, Left - physiology</subject><ispartof>Hypertension (Dallas, Tex. 1979), 2008-06, Vol.51 (6), p.1525-1530</ispartof><rights>2008 American Heart Association, Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5831-bdf23e6a9eb868fa38dbc621e6460a34ebb749255c3868e1081c199ee2f7396b3</citedby><cites>FETCH-LOGICAL-c5831-bdf23e6a9eb868fa38dbc621e6460a34ebb749255c3868e1081c199ee2f7396b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3673,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20393114$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18458163$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tzemos, Nikolaos</creatorcontrib><creatorcontrib>Lim, Pitt O</creatorcontrib><creatorcontrib>Wong, Suzanne</creatorcontrib><creatorcontrib>Struthers, Allan D</creatorcontrib><creatorcontrib>MacDonald, Thomas M</creatorcontrib><title>Adverse Cardiovascular Effects of Acute Salt Loading in Young Normotensive Individuals</title><title>Hypertension (Dallas, Tex. 1979)</title><addtitle>Hypertension</addtitle><description>We sought to explore the effects of salt loading in young normotensives on vascular endothelial function, echocardiographic left ventricular diastolic function, and electrocardiographic QT dispersion. Sixteen healthy normotensive male volunteers were randomized in a double-blind crossover fashion to 5-day treatment periods with either placebo or salt tablets (200 mmol/d of sodium) separated by a 2-week washout period. Throughout the study the volunteers were asked to maintain a low-salt diet. Forearm venous occlusion plethysmography and intraarterial infusions of acetylcholine (ACh), sodium nitroprusside (SNP), and N-monomethyl-l-arginine (L-NMMA) were used to assess vascular reactivity. Baseline and postsalt loading 12-lead ECGs and echocardiograms were also obtained. Twenty-four-hour ambulatory systolic blood pressure rose (117±11 to 121±8 mm Hg) significantly with salt loading. The endothelium-dependent responses to ACh were significantly blunted with salt compared to placebo (ΔFBF% 403 [50] versus 296 [31]; P<0.05) and L-NMMA (ΔFBF% −47.2 [4] versus −31 [3]; P<0.01). In contrast, the endothelium-independent response to SNP was not different between treatments. Color M-mode flow propagation velocity (CMMFPV), a preload index of left ventricular diastolic function, was significantly reduced with salt (64 [6] versus 59 [16] cm/s; P<0.05) suggesting increased ventricular stiffness. QT dispersion was also significantly increased with salt (58 [16] versus 48 [17] ms; P=0.02). Salt loading impaired vascular endothelial function, left ventricular mechanical relaxation, and electric repolarization in young healthy normotensives.</description><subject>Acetylcholine - administration & dosage</subject><subject>Acute Disease</subject><subject>Adult</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure - drug effects</subject><subject>Blood Pressure - physiology</subject><subject>Cardiology. Vascular system</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Cross-Over Studies</subject><subject>Diastole - drug effects</subject><subject>Diastole - physiology</subject><subject>Diet, Sodium-Restricted</subject><subject>Echocardiography</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - physiology</subject><subject>Enzyme Inhibitors - administration & dosage</subject><subject>Humans</subject><subject>Hypertension - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nitroprusside - administration & dosage</subject><subject>omega-N-Methylarginine - administration & dosage</subject><subject>Sodium Chloride, Dietary - adverse effects</subject><subject>Vasoconstriction - drug effects</subject><subject>Vasoconstriction - physiology</subject><subject>Vasodilator Agents - administration & dosage</subject><subject>Ventricular Function, Left - drug effects</subject><subject>Ventricular Function, Left - physiology</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkG1v0zAQgC0EYt3gLyALCb5l89mOa_MtqgqtVHXTNhD7FDnOmQXSeNhJp_17jFoNCUunO9vP-eUh5D2wcwAFF6u7q-X17XJ7s77cVqvqHJjOYbTSL8gMSi4LWSrxkswYGFkYgO8n5DSln4yBlHL-mpyAlqUGJWbkW9XuMSakCxvbLuxtclNvI116j25MNHhauWlEemP7kW6CbbvhB-0GehemXGxD3IURh9Ttka6Httt37WT79Ia88jnh22M-I18_L28Xq2Jz-WW9qDaFK7WAomk9F6iswSa_3luh28YpDqikYlZIbJq5NLwsncj7mD8KDoxB5H4ujGrEGfl4OPchht8TprHedclh39sBw5RqMErPjRYZ_HQAXQwpRfT1Q-x2Nj7VwOq_Vuv_rOZ1XR-s5uZ3x1umZoftv9ajxgx8OALZn-19tIPr0jPHmTACQGZOHrjH0I9Z-69-esRY32OWe1-zPCRXuuCMaabyrMjBQfwBrUWSHA</recordid><startdate>200806</startdate><enddate>200806</enddate><creator>Tzemos, Nikolaos</creator><creator>Lim, Pitt O</creator><creator>Wong, Suzanne</creator><creator>Struthers, Allan D</creator><creator>MacDonald, Thomas M</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>200806</creationdate><title>Adverse Cardiovascular Effects of Acute Salt Loading in Young Normotensive Individuals</title><author>Tzemos, Nikolaos ; Lim, Pitt O ; Wong, Suzanne ; Struthers, Allan D ; MacDonald, Thomas M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5831-bdf23e6a9eb868fa38dbc621e6460a34ebb749255c3868e1081c199ee2f7396b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Acetylcholine - administration & dosage</topic><topic>Acute Disease</topic><topic>Adult</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure - drug effects</topic><topic>Blood Pressure - physiology</topic><topic>Cardiology. Vascular system</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Cross-Over Studies</topic><topic>Diastole - drug effects</topic><topic>Diastole - physiology</topic><topic>Diet, Sodium-Restricted</topic><topic>Echocardiography</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Endothelium, Vascular - physiology</topic><topic>Enzyme Inhibitors - administration & dosage</topic><topic>Humans</topic><topic>Hypertension - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nitroprusside - administration & dosage</topic><topic>omega-N-Methylarginine - administration & dosage</topic><topic>Sodium Chloride, Dietary - adverse effects</topic><topic>Vasoconstriction - drug effects</topic><topic>Vasoconstriction - physiology</topic><topic>Vasodilator Agents - administration & dosage</topic><topic>Ventricular Function, Left - drug effects</topic><topic>Ventricular Function, Left - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tzemos, Nikolaos</creatorcontrib><creatorcontrib>Lim, Pitt O</creatorcontrib><creatorcontrib>Wong, Suzanne</creatorcontrib><creatorcontrib>Struthers, Allan D</creatorcontrib><creatorcontrib>MacDonald, Thomas M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tzemos, Nikolaos</au><au>Lim, Pitt O</au><au>Wong, Suzanne</au><au>Struthers, Allan D</au><au>MacDonald, Thomas M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adverse Cardiovascular Effects of Acute Salt Loading in Young Normotensive Individuals</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>2008-06</date><risdate>2008</risdate><volume>51</volume><issue>6</issue><spage>1525</spage><epage>1530</epage><pages>1525-1530</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><coden>HPRTDN</coden><abstract>We sought to explore the effects of salt loading in young normotensives on vascular endothelial function, echocardiographic left ventricular diastolic function, and electrocardiographic QT dispersion. Sixteen healthy normotensive male volunteers were randomized in a double-blind crossover fashion to 5-day treatment periods with either placebo or salt tablets (200 mmol/d of sodium) separated by a 2-week washout period. Throughout the study the volunteers were asked to maintain a low-salt diet. Forearm venous occlusion plethysmography and intraarterial infusions of acetylcholine (ACh), sodium nitroprusside (SNP), and N-monomethyl-l-arginine (L-NMMA) were used to assess vascular reactivity. Baseline and postsalt loading 12-lead ECGs and echocardiograms were also obtained. Twenty-four-hour ambulatory systolic blood pressure rose (117±11 to 121±8 mm Hg) significantly with salt loading. The endothelium-dependent responses to ACh were significantly blunted with salt compared to placebo (ΔFBF% 403 [50] versus 296 [31]; P<0.05) and L-NMMA (ΔFBF% −47.2 [4] versus −31 [3]; P<0.01). In contrast, the endothelium-independent response to SNP was not different between treatments. Color M-mode flow propagation velocity (CMMFPV), a preload index of left ventricular diastolic function, was significantly reduced with salt (64 [6] versus 59 [16] cm/s; P<0.05) suggesting increased ventricular stiffness. QT dispersion was also significantly increased with salt (58 [16] versus 48 [17] ms; P=0.02). Salt loading impaired vascular endothelial function, left ventricular mechanical relaxation, and electric repolarization in young healthy normotensives.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>18458163</pmid><doi>10.1161/HYPERTENSIONAHA.108.109868</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0194-911X |
| ispartof | Hypertension (Dallas, Tex. 1979), 2008-06, Vol.51 (6), p.1525-1530 |
| issn | 0194-911X 1524-4563 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_19687983 |
| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Acetylcholine - administration & dosage Acute Disease Adult Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Blood Pressure - physiology Cardiology. Vascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology Cross-Over Studies Diastole - drug effects Diastole - physiology Diet, Sodium-Restricted Echocardiography Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Enzyme Inhibitors - administration & dosage Humans Hypertension - physiopathology Male Medical sciences Nitroprusside - administration & dosage omega-N-Methylarginine - administration & dosage Sodium Chloride, Dietary - adverse effects Vasoconstriction - drug effects Vasoconstriction - physiology Vasodilator Agents - administration & dosage Ventricular Function, Left - drug effects Ventricular Function, Left - physiology |
| title | Adverse Cardiovascular Effects of Acute Salt Loading in Young Normotensive Individuals |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T08%3A50%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Adverse%20Cardiovascular%20Effects%20of%20Acute%20Salt%20Loading%20in%20Young%20Normotensive%20Individuals&rft.jtitle=Hypertension%20(Dallas,%20Tex.%201979)&rft.au=Tzemos,%20Nikolaos&rft.date=2008-06&rft.volume=51&rft.issue=6&rft.spage=1525&rft.epage=1530&rft.pages=1525-1530&rft.issn=0194-911X&rft.eissn=1524-4563&rft.coden=HPRTDN&rft_id=info:doi/10.1161/HYPERTENSIONAHA.108.109868&rft_dat=%3Cproquest_cross%3E19687983%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=19687983&rft_id=info:pmid/18458163&rfr_iscdi=true |