Exposure to gp120 of HIV-1 Induces an Increased Release of Arachidonic Acid in Rat Primary Neuronal Cell Culture Followed by NMDA Receptor-mediated Neurotoxicity

After incubation of highly enriched neurons from rat cerebral cortex with the HIV‐1 coat protein gp120 for 18 h, cells showed fragmentation of DNA at internucleosomal linkers followed by NMDA receptor‐mediated neurotoxicity. We report that in response to exposure to gp120 cells react with an increas...

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Veröffentlicht in:	The European journal of neuroscience 1995-06, Vol.7 (6), p.1353-1359
Hauptverfasser:	Ushijima, Hiroshi, Nishio, Osamu, Klöcking, Renate, Perovic, Sanja, Müller, Werner E.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals arachidonic acid Arachidonic Acid - antagonists & inhibitors Arachidonic Acid - metabolism Cell Death Cells, Cultured DNA Damage - drug effects gp120 HIV Envelope Protein gp120 - pharmacology HIV-1 Human immunodeficiency virus 1 neurons Neurons - drug effects Neurons - metabolism Neurons - physiology neurotoxicity Neurotoxins - pharmacology NMDA receptor Quinacrine - pharmacology Rats Rats, Wistar Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - physiology
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