Hepatitis C virus core protein downregulates E-cadherin expression via activation of DNA methyltransferase 1 and 3b

Abstract E-cadherin is a major cell adhesion molecule implicated as a potent tumor suppressor, which is frequently altered in human tumors including hepatocellular carcinoma. Here, we report that hepatitis C virus Core downregulates E-cadherin expression at the transcription level. This effect was a...

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Veröffentlicht in:	Cancer letters 2008-03, Vol.261 (2), p.244-252
Hauptverfasser:	Arora, Payal, Kim, Eun-Ok, Jung, Jin Kyu, Jang, Kyung Lib
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western Cadherins - genetics Cadherins - metabolism Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell adhesion & migration Cell Movement Core CpG Islands Deoxyribonucleic acid DNA DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - metabolism DNA Methylation DNA Methyltransferase 3B DNA Primers E-cadherin Enzymes Fluorescent Antibody Technique Gene expression Gene Expression Regulation, Neoplastic Hematology, Oncology and Palliative Medicine Hepatitis Hepatitis C virus Hepatocellular carcinoma Humans Kinases Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Plasmids Proteins Repressor Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Viral Core Proteins - metabolism
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