Synergy of irofulven in combination with other DNA damaging agents: synergistic interaction with altretamine, alkylating, and platinum-derived agents in the MV522 lung tumor model

Purpose Irofulven (MGI 114, NSC 683863) is a semisynthetic derivative of illudin S, a natural product present in the Omphalotus illudins (Jack O’Lantern) mushroom. This novel agent produces DNA damage, that in contrast to other agents, is predominately ignored by the global genome repair pathway of...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2008-12, Vol.63 (1), p.19-26
Hauptverfasser:	Kelner, Michael J., McMorris, Trevor C., Rojas, Rafael J., Estes, Leita A., Suthipinijtham, Pharnuk
Format:	Artikel
Sprache:	eng
Schlagworte:	Altretamine - administration & dosage Altretamine - pharmacology Animals Antineoplastic agents Antineoplastic Agents, Alkylating - administration & dosage Antineoplastic Agents, Alkylating - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Apoptosis - drug effects Biological and medical sciences Cancer Research Carcinoma - drug therapy Carcinoma - genetics DNA Damage - drug effects DNA, Neoplasm - drug effects Drug Synergism Female Lung Neoplasms - drug therapy Lung Neoplasms - genetics Medical sciences Medicine Medicine & Public Health Mice Mice, Inbred BALB C Mice, Nude Oncology Organoplatinum Compounds - administration & dosage Organoplatinum Compounds - pharmacology Original Article Pharmacology. Drug treatments Pharmacology/Toxicology Pneumology Random Allocation Sesquiterpenes - administration & dosage Sesquiterpenes - pharmacology Transcription, Genetic - drug effects Tumors of the respiratory system and mediastinum Xenograft Model Antitumor Assays
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