Low‐grade inflammation and muscular fitness on insulin resistance in adolescents: Results from LabMed Physical Activity Study
Background Low muscular fitness (MF) and low‐grade inflammation has been linked to insulin resistance (IR). Objective To evaluate the associations between MF and a clustered score of inflammatory biomarkers on IR and to investigate the combined impact of MF and inflammation on IR in adolescents. Met...
Gespeichert in:
| Veröffentlicht in: | Pediatric diabetes 2018-05, Vol.19 (3), p.429-435 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 435 |
|---|---|
| container_issue | 3 |
| container_start_page | 429 |
| container_title | Pediatric diabetes |
| container_volume | 19 |
| creator | Agostinis‐Sobrinho, César A Ramírez‐Vélez, Robinson García‐Hermoso, Antonio Moreira, Carla Lopes, Luís Oliveira‐Santos, José Abreu, Sandra Mota, Jorge Santos, Rute |
| description | Background
Low muscular fitness (MF) and low‐grade inflammation has been linked to insulin resistance (IR).
Objective
To evaluate the associations between MF and a clustered score of inflammatory biomarkers on IR and to investigate the combined impact of MF and inflammation on IR in adolescents.
Methods
This is a cross‐sectional analysis with 529 adolescents (267 girls) aged 12 to 18 years. Pubertal stage, socioeconomic status, adherence to the Mediterranean diet, cardiorespiratory fitness, and waist circumference were assessed. Standing long‐jump and isometric handgrip dynamometry were used as indicators of MF. Continuous score of clustered inflammatory biomarkers (InflaScore) (sum of Z‐scores of C‐reactive protein, C3, C4, fibrinogen, and leptin) and IR (homeostasis model assessment of insulin resistance [HOMA‐IR] estimated from fasting serum insulin and glucose) were assessed.
Results
HOMA‐IR and fasting insulin were positively associated with InflaScore and negatively associated with MF, independently of age, sex, pubertal stage, socioeconomic status, adherence to the Mediterranean diet, cardiorespiratory fitness, and waist circumference. Adolescents classified as High InflaScore/Unfit showed significantly higher HOMA‐IR when compared than those with High InflaScore/Fit and those with Low InflaScore/Fit (F(3,519) = 4.761, P |
| doi_str_mv | 10.1111/pedi.12607 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1968444591</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2030487022</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3937-f51ad2ffd86c5078fa2f3eae04079fe56015e6d2bf4f4f63af39190e96de99463</originalsourceid><addsrcrecordid>eNp90c9qFTEUBvBQlLbWbvoAEnAjwq3JJPMn7kpttXDFoha6C7mTE03JZK45Gcus6iP4jD6Jud7ahQuTRUL45ePAR8gRZ8e8rFdrsP6YVw1rd8g-F0otaim7Rw93cb1HniDeMMZbJeQu2asUbznv6n1ytxxvf_34-SUZC9RHF8wwmOzHSE20dJiwn4JJ1PkcAZGWdx9xCj7SBOgxm9hv_lFjxwDYQ8z4mn6EQjJSl8aBLs3qPVh6-XVG35tAT_rsv_s80095svNT8tiZgHB4fx6Qq_Ozz6fvFssPby9OT5aLXijRLlzNja2cs13T16ztnKmcAANMslY5qBvGa2hstXKy7EYYJxRXDFRjQSnZiAPyYpu7TuO3CTDrwZdxQzARxgk1V00npawVL_T5P_RmnFIs0-mKCSa7llVVUS-3qk8jYgKn18kPJs2aM72pRW9q0X9qKfjZfeS0GsA-0L89FMC34NYHmP8TpS_P3lxsQ38DSuOapQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2030487022</pqid></control><display><type>article</type><title>Low‐grade inflammation and muscular fitness on insulin resistance in adolescents: Results from LabMed Physical Activity Study</title><source>Wiley Online Library All Journals</source><creator>Agostinis‐Sobrinho, César A ; Ramírez‐Vélez, Robinson ; García‐Hermoso, Antonio ; Moreira, Carla ; Lopes, Luís ; Oliveira‐Santos, José ; Abreu, Sandra ; Mota, Jorge ; Santos, Rute</creator><creatorcontrib>Agostinis‐Sobrinho, César A ; Ramírez‐Vélez, Robinson ; García‐Hermoso, Antonio ; Moreira, Carla ; Lopes, Luís ; Oliveira‐Santos, José ; Abreu, Sandra ; Mota, Jorge ; Santos, Rute</creatorcontrib><description>Background
Low muscular fitness (MF) and low‐grade inflammation has been linked to insulin resistance (IR).
Objective
To evaluate the associations between MF and a clustered score of inflammatory biomarkers on IR and to investigate the combined impact of MF and inflammation on IR in adolescents.
Methods
This is a cross‐sectional analysis with 529 adolescents (267 girls) aged 12 to 18 years. Pubertal stage, socioeconomic status, adherence to the Mediterranean diet, cardiorespiratory fitness, and waist circumference were assessed. Standing long‐jump and isometric handgrip dynamometry were used as indicators of MF. Continuous score of clustered inflammatory biomarkers (InflaScore) (sum of Z‐scores of C‐reactive protein, C3, C4, fibrinogen, and leptin) and IR (homeostasis model assessment of insulin resistance [HOMA‐IR] estimated from fasting serum insulin and glucose) were assessed.
Results
HOMA‐IR and fasting insulin were positively associated with InflaScore and negatively associated with MF, independently of age, sex, pubertal stage, socioeconomic status, adherence to the Mediterranean diet, cardiorespiratory fitness, and waist circumference. Adolescents classified as High InflaScore/Unfit showed significantly higher HOMA‐IR when compared than those with High InflaScore/Fit and those with Low InflaScore/Fit (F(3,519) = 4.761, P < .003), after adjustments for potential confounders. Unfit adolescents with high InflaScore had the highest odds of expressing high HOMA‐IR (odds ratio, OR = 2.40, 95% confidence interval [CI]: 1.2‐5.6) and insulin risk (2.53 95% CI, 1.5‐5.9) when compared to those of the Low InflaScore/Fit group, after adjustments for potential confounders.
Conclusion
Higher levels of MF seem to minimize the deleterious effect of inflammation on IR.</description><identifier>ISSN: 1399-543X</identifier><identifier>EISSN: 1399-5448</identifier><identifier>DOI: 10.1111/pedi.12607</identifier><identifier>PMID: 29171185</identifier><language>eng</language><publisher>Former Munksgaard: John Wiley & Sons A/S</publisher><subject>Adolescents ; Biomarkers ; Cardiorespiratory fitness ; Diet ; Exercise ; Fibrinogen ; handgrip ; Homeostasis ; Inflammation ; Insulin ; Insulin resistance ; Isometric ; Leptin ; Physical activity ; Physical fitness ; Socioeconomic factors ; strength ; Teenagers ; youth</subject><ispartof>Pediatric diabetes, 2018-05, Vol.19 (3), p.429-435</ispartof><rights>2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3937-f51ad2ffd86c5078fa2f3eae04079fe56015e6d2bf4f4f63af39190e96de99463</citedby><cites>FETCH-LOGICAL-c3937-f51ad2ffd86c5078fa2f3eae04079fe56015e6d2bf4f4f63af39190e96de99463</cites><orcidid>0000-0003-3075-6960 ; 0000-0001-9104-9042</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpedi.12607$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpedi.12607$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29171185$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Agostinis‐Sobrinho, César A</creatorcontrib><creatorcontrib>Ramírez‐Vélez, Robinson</creatorcontrib><creatorcontrib>García‐Hermoso, Antonio</creatorcontrib><creatorcontrib>Moreira, Carla</creatorcontrib><creatorcontrib>Lopes, Luís</creatorcontrib><creatorcontrib>Oliveira‐Santos, José</creatorcontrib><creatorcontrib>Abreu, Sandra</creatorcontrib><creatorcontrib>Mota, Jorge</creatorcontrib><creatorcontrib>Santos, Rute</creatorcontrib><title>Low‐grade inflammation and muscular fitness on insulin resistance in adolescents: Results from LabMed Physical Activity Study</title><title>Pediatric diabetes</title><addtitle>Pediatr Diabetes</addtitle><description>Background
Low muscular fitness (MF) and low‐grade inflammation has been linked to insulin resistance (IR).
Objective
To evaluate the associations between MF and a clustered score of inflammatory biomarkers on IR and to investigate the combined impact of MF and inflammation on IR in adolescents.
Methods
This is a cross‐sectional analysis with 529 adolescents (267 girls) aged 12 to 18 years. Pubertal stage, socioeconomic status, adherence to the Mediterranean diet, cardiorespiratory fitness, and waist circumference were assessed. Standing long‐jump and isometric handgrip dynamometry were used as indicators of MF. Continuous score of clustered inflammatory biomarkers (InflaScore) (sum of Z‐scores of C‐reactive protein, C3, C4, fibrinogen, and leptin) and IR (homeostasis model assessment of insulin resistance [HOMA‐IR] estimated from fasting serum insulin and glucose) were assessed.
Results
HOMA‐IR and fasting insulin were positively associated with InflaScore and negatively associated with MF, independently of age, sex, pubertal stage, socioeconomic status, adherence to the Mediterranean diet, cardiorespiratory fitness, and waist circumference. Adolescents classified as High InflaScore/Unfit showed significantly higher HOMA‐IR when compared than those with High InflaScore/Fit and those with Low InflaScore/Fit (F(3,519) = 4.761, P < .003), after adjustments for potential confounders. Unfit adolescents with high InflaScore had the highest odds of expressing high HOMA‐IR (odds ratio, OR = 2.40, 95% confidence interval [CI]: 1.2‐5.6) and insulin risk (2.53 95% CI, 1.5‐5.9) when compared to those of the Low InflaScore/Fit group, after adjustments for potential confounders.
Conclusion
Higher levels of MF seem to minimize the deleterious effect of inflammation on IR.</description><subject>Adolescents</subject><subject>Biomarkers</subject><subject>Cardiorespiratory fitness</subject><subject>Diet</subject><subject>Exercise</subject><subject>Fibrinogen</subject><subject>handgrip</subject><subject>Homeostasis</subject><subject>Inflammation</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Isometric</subject><subject>Leptin</subject><subject>Physical activity</subject><subject>Physical fitness</subject><subject>Socioeconomic factors</subject><subject>strength</subject><subject>Teenagers</subject><subject>youth</subject><issn>1399-543X</issn><issn>1399-5448</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp90c9qFTEUBvBQlLbWbvoAEnAjwq3JJPMn7kpttXDFoha6C7mTE03JZK45Gcus6iP4jD6Jud7ahQuTRUL45ePAR8gRZ8e8rFdrsP6YVw1rd8g-F0otaim7Rw93cb1HniDeMMZbJeQu2asUbznv6n1ytxxvf_34-SUZC9RHF8wwmOzHSE20dJiwn4JJ1PkcAZGWdx9xCj7SBOgxm9hv_lFjxwDYQ8z4mn6EQjJSl8aBLs3qPVh6-XVG35tAT_rsv_s80095svNT8tiZgHB4fx6Qq_Ozz6fvFssPby9OT5aLXijRLlzNja2cs13T16ztnKmcAANMslY5qBvGa2hstXKy7EYYJxRXDFRjQSnZiAPyYpu7TuO3CTDrwZdxQzARxgk1V00npawVL_T5P_RmnFIs0-mKCSa7llVVUS-3qk8jYgKn18kPJs2aM72pRW9q0X9qKfjZfeS0GsA-0L89FMC34NYHmP8TpS_P3lxsQ38DSuOapQ</recordid><startdate>201805</startdate><enddate>201805</enddate><creator>Agostinis‐Sobrinho, César A</creator><creator>Ramírez‐Vélez, Robinson</creator><creator>García‐Hermoso, Antonio</creator><creator>Moreira, Carla</creator><creator>Lopes, Luís</creator><creator>Oliveira‐Santos, José</creator><creator>Abreu, Sandra</creator><creator>Mota, Jorge</creator><creator>Santos, Rute</creator><general>John Wiley & Sons A/S</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3075-6960</orcidid><orcidid>https://orcid.org/0000-0001-9104-9042</orcidid></search><sort><creationdate>201805</creationdate><title>Low‐grade inflammation and muscular fitness on insulin resistance in adolescents: Results from LabMed Physical Activity Study</title><author>Agostinis‐Sobrinho, César A ; Ramírez‐Vélez, Robinson ; García‐Hermoso, Antonio ; Moreira, Carla ; Lopes, Luís ; Oliveira‐Santos, José ; Abreu, Sandra ; Mota, Jorge ; Santos, Rute</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3937-f51ad2ffd86c5078fa2f3eae04079fe56015e6d2bf4f4f63af39190e96de99463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescents</topic><topic>Biomarkers</topic><topic>Cardiorespiratory fitness</topic><topic>Diet</topic><topic>Exercise</topic><topic>Fibrinogen</topic><topic>handgrip</topic><topic>Homeostasis</topic><topic>Inflammation</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Isometric</topic><topic>Leptin</topic><topic>Physical activity</topic><topic>Physical fitness</topic><topic>Socioeconomic factors</topic><topic>strength</topic><topic>Teenagers</topic><topic>youth</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Agostinis‐Sobrinho, César A</creatorcontrib><creatorcontrib>Ramírez‐Vélez, Robinson</creatorcontrib><creatorcontrib>García‐Hermoso, Antonio</creatorcontrib><creatorcontrib>Moreira, Carla</creatorcontrib><creatorcontrib>Lopes, Luís</creatorcontrib><creatorcontrib>Oliveira‐Santos, José</creatorcontrib><creatorcontrib>Abreu, Sandra</creatorcontrib><creatorcontrib>Mota, Jorge</creatorcontrib><creatorcontrib>Santos, Rute</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric diabetes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Agostinis‐Sobrinho, César A</au><au>Ramírez‐Vélez, Robinson</au><au>García‐Hermoso, Antonio</au><au>Moreira, Carla</au><au>Lopes, Luís</au><au>Oliveira‐Santos, José</au><au>Abreu, Sandra</au><au>Mota, Jorge</au><au>Santos, Rute</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low‐grade inflammation and muscular fitness on insulin resistance in adolescents: Results from LabMed Physical Activity Study</atitle><jtitle>Pediatric diabetes</jtitle><addtitle>Pediatr Diabetes</addtitle><date>2018-05</date><risdate>2018</risdate><volume>19</volume><issue>3</issue><spage>429</spage><epage>435</epage><pages>429-435</pages><issn>1399-543X</issn><eissn>1399-5448</eissn><abstract>Background
Low muscular fitness (MF) and low‐grade inflammation has been linked to insulin resistance (IR).
Objective
To evaluate the associations between MF and a clustered score of inflammatory biomarkers on IR and to investigate the combined impact of MF and inflammation on IR in adolescents.
Methods
This is a cross‐sectional analysis with 529 adolescents (267 girls) aged 12 to 18 years. Pubertal stage, socioeconomic status, adherence to the Mediterranean diet, cardiorespiratory fitness, and waist circumference were assessed. Standing long‐jump and isometric handgrip dynamometry were used as indicators of MF. Continuous score of clustered inflammatory biomarkers (InflaScore) (sum of Z‐scores of C‐reactive protein, C3, C4, fibrinogen, and leptin) and IR (homeostasis model assessment of insulin resistance [HOMA‐IR] estimated from fasting serum insulin and glucose) were assessed.
Results
HOMA‐IR and fasting insulin were positively associated with InflaScore and negatively associated with MF, independently of age, sex, pubertal stage, socioeconomic status, adherence to the Mediterranean diet, cardiorespiratory fitness, and waist circumference. Adolescents classified as High InflaScore/Unfit showed significantly higher HOMA‐IR when compared than those with High InflaScore/Fit and those with Low InflaScore/Fit (F(3,519) = 4.761, P < .003), after adjustments for potential confounders. Unfit adolescents with high InflaScore had the highest odds of expressing high HOMA‐IR (odds ratio, OR = 2.40, 95% confidence interval [CI]: 1.2‐5.6) and insulin risk (2.53 95% CI, 1.5‐5.9) when compared to those of the Low InflaScore/Fit group, after adjustments for potential confounders.
Conclusion
Higher levels of MF seem to minimize the deleterious effect of inflammation on IR.</abstract><cop>Former Munksgaard</cop><pub>John Wiley & Sons A/S</pub><pmid>29171185</pmid><doi>10.1111/pedi.12607</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-3075-6960</orcidid><orcidid>https://orcid.org/0000-0001-9104-9042</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1399-543X |
| ispartof | Pediatric diabetes, 2018-05, Vol.19 (3), p.429-435 |
| issn | 1399-543X 1399-5448 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1968444591 |
| source | Wiley Online Library All Journals |
| subjects | Adolescents Biomarkers Cardiorespiratory fitness Diet Exercise Fibrinogen handgrip Homeostasis Inflammation Insulin Insulin resistance Isometric Leptin Physical activity Physical fitness Socioeconomic factors strength Teenagers youth |
| title | Low‐grade inflammation and muscular fitness on insulin resistance in adolescents: Results from LabMed Physical Activity Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T07%3A26%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Low%E2%80%90grade%20inflammation%20and%20muscular%20fitness%20on%20insulin%20resistance%20in%20adolescents:%20Results%20from%20LabMed%20Physical%20Activity%20Study&rft.jtitle=Pediatric%20diabetes&rft.au=Agostinis%E2%80%90Sobrinho,%20C%C3%A9sar%20A&rft.date=2018-05&rft.volume=19&rft.issue=3&rft.spage=429&rft.epage=435&rft.pages=429-435&rft.issn=1399-543X&rft.eissn=1399-5448&rft_id=info:doi/10.1111/pedi.12607&rft_dat=%3Cproquest_cross%3E2030487022%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2030487022&rft_id=info:pmid/29171185&rfr_iscdi=true |