Sleep disorder and altered locomotor activity as biomarkers of the Parkinson’s disease cholinopathy in rat

•Hippocampal sleep disorder is the first and long-lasting hallmark of PD cholinopathy.•High voltage sleep spindle dynamics during REM sleep reflects PD cholinopathy.•Hypokinesia reflects impaired cholinergic impact in motor control regulatory network.•Amphetamine induces hyperactivity in the hypokin...

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Veröffentlicht in:	Behavioural brain research 2018-02, Vol.339, p.79-92
Hauptverfasser:	Ciric, Jelena, Lazic, Katarina, Kapor, Slobodan, Perovic, Milka, Petrovic, Jelena, Pesic, Vesna, Kanazir, Selma, Saponjic, Jasna
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers - analysis Brain - physiology c-Fos Electroencephalography - methods High voltage sleep spindles Locomotion - physiology Locomotor activity Male Parkinson Disease - pathology Parkinson Disease - physiopathology Parkinson’s disease Pedunculopontine tegmental nucleus Rats, Wistar Sleep Sleep - physiology Sleep Wake Disorders - physiopathology Wakefulness - physiology
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