Deposition transfection technology using a DNA complex with a thermoresponsive cationic star polymer

A novel non-viral gene transfection method in which DNA complexes were kept in contact with a deposition surface (deposition transfection) was developed. We designed a novel aqueous thermoresponsive adsorbent material for DNA deposition, which was a star-shaped copolymer with 4-branched chains. Each...

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Veröffentlicht in:	Journal of controlled release 2007-11, Vol.123 (3), p.239-246
Hauptverfasser:	Zhou, Yue-Min, Ishikawa, Ayaka, Okahashi, Ryohei, Uchida, Kingo, Nemoto, Yasushi, Nakayama, Mitsuko, Nakayama, Yasuhide
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamides - chemical synthesis Acrylamides - toxicity Acrylic Resins - chemical synthesis Acrylic Resins - toxicity Animals Biological and medical sciences Cationic polymer Cations Cell Survival - drug effects Cercopithecus aethiops Chemical Precipitation COS Cells Deposition transfection DNA - chemistry DNA - metabolism DNA delivery General pharmacology Genes, Reporter Luciferases - metabolism Medical sciences Molecular Structure Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Reverse transfection Temperature Thermoresponsive polymer Transfection - methods
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