DNA damage and nitric oxide synthesis in experimentally infected Balb/c mice with Trypanosoma cruzi

This study aimed to evaluate whether experimental Chagas disease in acute phase under benznidazole therapy can cause DNA damage in peripheral blood, liver, heart, and spleen cells or induce nitric oxide synthesis in spleen cells. Twenty Balb/c mice were distributed into four groups: control (non-inf...

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Veröffentlicht in:	Experimental parasitology 2007-07, Vol.116 (3), p.296-301
Hauptverfasser:	Ribeiro, Daniel A., Calvi, Sueli A., Picka, Mariele M., Persi, Eliana, de Carvalho, Thaís B., Caetano, Priscila K., Nagoshi, Lidiana R., Lima, Carlos R.G., Machado, Jussara M., Salvadori, Daisy M.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Cells - pathology Chagas disease Chagas Disease - complications Chagas Disease - drug therapy Chagas Disease - genetics Chagas Disease - metabolism DNA Damage Fundamental and applied biological sciences. Psychology Life cycle. Host-agent relationship. Pathogenesis Liver - cytology Male Mice Mice, Inbred BALB C Myocardium - cytology Neoplasms - etiology Nitric oxide Nitric Oxide - biosynthesis Nitroimidazoles - therapeutic use Protozoa Random Allocation Single cell gel (comet) assay Spleen - cytology Spleen - metabolism Trypanocidal Agents - therapeutic use Trypanosoma cruzi Trypanosoma cruzi - pathogenicity
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