Human milk H2O2 content: does it benefit preterm infants?
Background Human milk has a high content of the antimicrobial compound hydrogen peroxide (H 2 O 2 ). As opposed to healthy full-term infants, preterm neonates are fed previously expressed and stored maternal milk. These practices may favor H 2 O 2 decomposition, thus limiting its potential benefit t...
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| Veröffentlicht in: | Pediatric research 2018-03, Vol.83 (3), p.687-692 |
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| creator | Cieslak, Monika Ferreira, Cristina H F Shifrin, Yulia Pan, Jingyi Belik, Jaques |
| description | Background
Human milk has a high content of the antimicrobial compound hydrogen peroxide (H
2
O
2
). As opposed to healthy full-term infants, preterm neonates are fed previously expressed and stored maternal milk. These practices may favor H
2
O
2
decomposition, thus limiting its potential benefit to preterm infants. The goal of this study was to evaluate the factors responsible for H
2
O
2
generation and degradation in breastmilk.
Methods
Human donors’ and rats’ milk, along with rat mammary tissue were evaluated. The role of oxytocin and xanthine oxidase on H
2
O
2
generation, its pH-dependent stability, as well as its degradation via lactoperoxidase and catalase was measured in milk.
Results
Breast tissue xanthine oxidase is responsible for the H
2
O
2
generation and its milk content is dependent on oxytocin stimulation. Stability of the human milk H
2
O
2
content is pH-dependent and greatest in the acidic range. Complete H
2
O
2
degradation occurs when human milk is maintained, longer than 10 min, at room temperature and this process is suppressed by lactoperoxidase and catalase inhibition.
Conclusion
Fresh breastmilk H
2
O
2
content is labile and quickly degrades at room temperature. Further investigation on breastmilk handling techniques to preserve its H
2
O
2
content, when gavage-fed to preterm infants is warranted. |
| doi_str_mv | 10.1038/pr.2017.303 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1967863016</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1967863016</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-62e8403c0767c6b33be49a4df1d43f9281b4238ba82aa6698ef65a032abf8db63</originalsourceid><addsrcrecordid>eNp9kEFLxDAQRoMouK6e_AMFL4J2nWTSNPUisqgrLOxFzyFtE-napjVpD_57WyoIIp4-Bh6P4RFyTmFFAeVN51cMaLpCwAOyoAlCDJynh2QBgDTGLJPH5CSEPQDlieQLkm2GRruoqer3aMN2LCpa1xvX30Zla0JU9VFunLHjdt70xjdR5ax2fbg7JUdW18Gcfe-SvD4-vKw38Xb39Ly-38YFMtHHghnJAQtIRVqIHDE3PNO8tLTkaDMmac4ZylxLprUQmTRWJBqQ6dzKMhe4JJezt_Ptx2BCr5oqFKautTPtEBTNRCoFAp3Qi1_ovh28G79TDBEgSccw_1LAxmaUi8l1NVOFb0PwxqrOV432n4qCmmKPt5piq9l5PdNhpNyb8T_Ov_AvtwR8qA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2025301466</pqid></control><display><type>article</type><title>Human milk H2O2 content: does it benefit preterm infants?</title><source>Springer Nature - Complete Springer Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Cieslak, Monika ; Ferreira, Cristina H F ; Shifrin, Yulia ; Pan, Jingyi ; Belik, Jaques</creator><creatorcontrib>Cieslak, Monika ; Ferreira, Cristina H F ; Shifrin, Yulia ; Pan, Jingyi ; Belik, Jaques</creatorcontrib><description>Background
Human milk has a high content of the antimicrobial compound hydrogen peroxide (H
2
O
2
). As opposed to healthy full-term infants, preterm neonates are fed previously expressed and stored maternal milk. These practices may favor H
2
O
2
decomposition, thus limiting its potential benefit to preterm infants. The goal of this study was to evaluate the factors responsible for H
2
O
2
generation and degradation in breastmilk.
Methods
Human donors’ and rats’ milk, along with rat mammary tissue were evaluated. The role of oxytocin and xanthine oxidase on H
2
O
2
generation, its pH-dependent stability, as well as its degradation via lactoperoxidase and catalase was measured in milk.
Results
Breast tissue xanthine oxidase is responsible for the H
2
O
2
generation and its milk content is dependent on oxytocin stimulation. Stability of the human milk H
2
O
2
content is pH-dependent and greatest in the acidic range. Complete H
2
O
2
degradation occurs when human milk is maintained, longer than 10 min, at room temperature and this process is suppressed by lactoperoxidase and catalase inhibition.
Conclusion
Fresh breastmilk H
2
O
2
content is labile and quickly degrades at room temperature. Further investigation on breastmilk handling techniques to preserve its H
2
O
2
content, when gavage-fed to preterm infants is warranted.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1038/pr.2017.303</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>692/700/1720/3185 ; 692/700/2814 ; Baby foods ; basic-science-investigation ; Breastfeeding & lactation ; Hydrogen peroxide ; Medicine ; Medicine & Public Health ; Newborn babies ; Pediatric Surgery ; Pediatrics ; Premature babies ; Premature birth</subject><ispartof>Pediatric research, 2018-03, Vol.83 (3), p.687-692</ispartof><rights>International Pediatric Research Foundation, Inc. 2018</rights><rights>Copyright Nature Publishing Group Mar 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c326t-62e8403c0767c6b33be49a4df1d43f9281b4238ba82aa6698ef65a032abf8db63</citedby><cites>FETCH-LOGICAL-c326t-62e8403c0767c6b33be49a4df1d43f9281b4238ba82aa6698ef65a032abf8db63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/pr.2017.303$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/pr.2017.303$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Cieslak, Monika</creatorcontrib><creatorcontrib>Ferreira, Cristina H F</creatorcontrib><creatorcontrib>Shifrin, Yulia</creatorcontrib><creatorcontrib>Pan, Jingyi</creatorcontrib><creatorcontrib>Belik, Jaques</creatorcontrib><title>Human milk H2O2 content: does it benefit preterm infants?</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><description>Background
Human milk has a high content of the antimicrobial compound hydrogen peroxide (H
2
O
2
). As opposed to healthy full-term infants, preterm neonates are fed previously expressed and stored maternal milk. These practices may favor H
2
O
2
decomposition, thus limiting its potential benefit to preterm infants. The goal of this study was to evaluate the factors responsible for H
2
O
2
generation and degradation in breastmilk.
Methods
Human donors’ and rats’ milk, along with rat mammary tissue were evaluated. The role of oxytocin and xanthine oxidase on H
2
O
2
generation, its pH-dependent stability, as well as its degradation via lactoperoxidase and catalase was measured in milk.
Results
Breast tissue xanthine oxidase is responsible for the H
2
O
2
generation and its milk content is dependent on oxytocin stimulation. Stability of the human milk H
2
O
2
content is pH-dependent and greatest in the acidic range. Complete H
2
O
2
degradation occurs when human milk is maintained, longer than 10 min, at room temperature and this process is suppressed by lactoperoxidase and catalase inhibition.
Conclusion
Fresh breastmilk H
2
O
2
content is labile and quickly degrades at room temperature. Further investigation on breastmilk handling techniques to preserve its H
2
O
2
content, when gavage-fed to preterm infants is warranted.</description><subject>692/700/1720/3185</subject><subject>692/700/2814</subject><subject>Baby foods</subject><subject>basic-science-investigation</subject><subject>Breastfeeding & lactation</subject><subject>Hydrogen peroxide</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Newborn babies</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Premature babies</subject><subject>Premature birth</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kEFLxDAQRoMouK6e_AMFL4J2nWTSNPUisqgrLOxFzyFtE-napjVpD_57WyoIIp4-Bh6P4RFyTmFFAeVN51cMaLpCwAOyoAlCDJynh2QBgDTGLJPH5CSEPQDlieQLkm2GRruoqer3aMN2LCpa1xvX30Zla0JU9VFunLHjdt70xjdR5ax2fbg7JUdW18Gcfe-SvD4-vKw38Xb39Ly-38YFMtHHghnJAQtIRVqIHDE3PNO8tLTkaDMmac4ZylxLprUQmTRWJBqQ6dzKMhe4JJezt_Ptx2BCr5oqFKautTPtEBTNRCoFAp3Qi1_ovh28G79TDBEgSccw_1LAxmaUi8l1NVOFb0PwxqrOV432n4qCmmKPt5piq9l5PdNhpNyb8T_Ov_AvtwR8qA</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Cieslak, Monika</creator><creator>Ferreira, Cristina H F</creator><creator>Shifrin, Yulia</creator><creator>Pan, Jingyi</creator><creator>Belik, Jaques</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20180301</creationdate><title>Human milk H2O2 content: does it benefit preterm infants?</title><author>Cieslak, Monika ; Ferreira, Cristina H F ; Shifrin, Yulia ; Pan, Jingyi ; Belik, Jaques</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-62e8403c0767c6b33be49a4df1d43f9281b4238ba82aa6698ef65a032abf8db63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>692/700/1720/3185</topic><topic>692/700/2814</topic><topic>Baby foods</topic><topic>basic-science-investigation</topic><topic>Breastfeeding & lactation</topic><topic>Hydrogen peroxide</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Newborn babies</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Premature babies</topic><topic>Premature birth</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cieslak, Monika</creatorcontrib><creatorcontrib>Ferreira, Cristina H F</creatorcontrib><creatorcontrib>Shifrin, Yulia</creatorcontrib><creatorcontrib>Pan, Jingyi</creatorcontrib><creatorcontrib>Belik, Jaques</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cieslak, Monika</au><au>Ferreira, Cristina H F</au><au>Shifrin, Yulia</au><au>Pan, Jingyi</au><au>Belik, Jaques</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human milk H2O2 content: does it benefit preterm infants?</atitle><jtitle>Pediatric research</jtitle><stitle>Pediatr Res</stitle><date>2018-03-01</date><risdate>2018</risdate><volume>83</volume><issue>3</issue><spage>687</spage><epage>692</epage><pages>687-692</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><abstract>Background
Human milk has a high content of the antimicrobial compound hydrogen peroxide (H
2
O
2
). As opposed to healthy full-term infants, preterm neonates are fed previously expressed and stored maternal milk. These practices may favor H
2
O
2
decomposition, thus limiting its potential benefit to preterm infants. The goal of this study was to evaluate the factors responsible for H
2
O
2
generation and degradation in breastmilk.
Methods
Human donors’ and rats’ milk, along with rat mammary tissue were evaluated. The role of oxytocin and xanthine oxidase on H
2
O
2
generation, its pH-dependent stability, as well as its degradation via lactoperoxidase and catalase was measured in milk.
Results
Breast tissue xanthine oxidase is responsible for the H
2
O
2
generation and its milk content is dependent on oxytocin stimulation. Stability of the human milk H
2
O
2
content is pH-dependent and greatest in the acidic range. Complete H
2
O
2
degradation occurs when human milk is maintained, longer than 10 min, at room temperature and this process is suppressed by lactoperoxidase and catalase inhibition.
Conclusion
Fresh breastmilk H
2
O
2
content is labile and quickly degrades at room temperature. Further investigation on breastmilk handling techniques to preserve its H
2
O
2
content, when gavage-fed to preterm infants is warranted.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><doi>10.1038/pr.2017.303</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Pediatric research, 2018-03, Vol.83 (3), p.687-692 |
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| source | Springer Nature - Complete Springer Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | 692/700/1720/3185 692/700/2814 Baby foods basic-science-investigation Breastfeeding & lactation Hydrogen peroxide Medicine Medicine & Public Health Newborn babies Pediatric Surgery Pediatrics Premature babies Premature birth |
| title | Human milk H2O2 content: does it benefit preterm infants? |
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