A Quantum Mechanical Investigation of Possible Mechanisms for the Nucleotidyl Transfer Reaction Catalyzed by DNA Polymerase beta2

Several quantum mechanical (QM) and hybrid quantum/molecular mechanical (QM/MM) studies have been employed recently to analyze the nucleotidyl transfer reaction in DNA polymerase beta2 (pol beta2). Our examination reveals strong dependence of the reported mechanism on the initial molecular model. Th...

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Veröffentlicht in:	The journal of physical chemistry. B 2007-01, Vol.111 (38), p.11244-11252
Hauptverfasser:	Bojin, Mihaela D, Schlick, Tamar
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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