Marine sponge-derived polymeric alkylpyridinium salts as a novel tumor chemotherapeutic targeting the cholinergic system in lung tumors

Previous studies have shown that the cholinergic system plays a pivotal rule in small cell lung cancer (SCLC) cell growth through an autocrine loop that activates the nicotinic cholinergic receptor, which together with the activation of this receptor by nicotine links SCLC evolution with tobacco use...

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Veröffentlicht in:	International journal of oncology 2006-12, Vol.29 (6), p.1381-1388
Hauptverfasser:	PALEARI, Laura, TROMBINO, Sonya, ALBINI, Adriana, FALUGI, Carla, GALLUS, Lorenzo, CARLONE, Sebastiano, ANGELINI, Cristiano, SEPCIC, Kristina, TURK, Tom, FAIMALI, Marco, NOONAN, Douglas M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma, Clear Cell Animals Apoptosis - drug effects Biological and medical sciences Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - enzymology Carcinoma, Non-Small-Cell Lung - pathology Cell Communication - drug effects Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - isolation & purification Cholinesterase Inhibitors - pharmacology Dose-Response Relationship, Drug Humans Lung Neoplasms - drug therapy Lung Neoplasms - enzymology Lung Neoplasms - pathology Marine Medical sciences Mice Mice, Inbred C57BL Pneumology Polymers - chemistry Polymers - isolation & purification Polymers - pharmacology Porifera - chemistry Pyridinium Compounds - chemistry Pyridinium Compounds - isolation & purification Pyridinium Compounds - pharmacology Reniera sarai Tumors Tumors of the respiratory system and mediastinum Vesicular Acetylcholine Transport Proteins - antagonists & inhibitors Vesicular Acetylcholine Transport Proteins - metabolism
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